Synthesis and antiviral activity of novel pyrazole derivatives containing oxime esters group

1-Substituted-5-substitutedphenylthio-4-pyrazolaldoxime ester derivatives 4a– 4n, were synthesized from the starting material 1-substitutedphenyl-3-methyl-5-substitutedphenylthio-4- pyrazolaldoximes 3 by treatment with acyl chloride. The bioassay results showed that title compounds possessed weak to...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-11, Vol.16 (22), p.9699-9707
Hauptverfasser:	Ouyang, Guiping, Chen, Zhuo, Cai, Xue-Jian, Song, Bao-An, Bhadury, Pinaki S., Yang, Song, Jin, Lin-Hong, Xue, Wei, Hu, De-Yu, Zeng, Song
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Antiviral bioactivity Biological and medical sciences Crystallography, X-Ray Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Esters - chemical synthesis Esters - chemistry Esters - pharmacology Fundamental and applied biological sciences. Psychology Generalities. Techniques. Transmission, epidemiology, ecology. Antiviral substances, control Mechanism of action Nicotiana - metabolism Nicotiana - virology Oxime ester moiety Oximes - chemical synthesis Oximes - chemistry Oximes - pharmacology Phytopathology. Animal pests. Plant and forest protection Plant Leaves - metabolism Plant Leaves - virology Plant viruses and viroids Pyrazole Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA - analysis RNA - genetics Synthesis Tobacco Mosaic Virus - drug effects
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