Entorhinal cortex volume measured with 3T MRI is positively correlated with the Wechsler Memory Scale-Revised logical/verbal memory score for healthy subjects
Introduction Previous studies revealed a correlation between local brain volume and cognitive function. The aim of the present study was to investigate the correlation between local gray matter volume and the Wechsler Memory Scale-Revised (WMS-R) logical/verbal memory (WMS-R-verbal) score in healthy...
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| Veröffentlicht in: | Neuroradiology 2011-08, Vol.53 (8), p.617-622 |
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| creator | Goto, Masami Abe, Osamu Miyati, Tosiaki Yoshikawa, Takeharu Hayashi, Naoto Takao, Hidemasa Inano, Sachiko Kabasawa, Hiroyuki Mori, Harushi Kunimatsu, Akira Aoki, Shigeki Ino, Kenji Iida, Kyouhito Yano, Keiichi Ohtomo, Kuni |
| description | Introduction
Previous studies revealed a correlation between local brain volume and cognitive function. The aim of the present study was to investigate the correlation between local gray matter volume and the Wechsler Memory Scale-Revised (WMS-R) logical/verbal memory (WMS-R-verbal) score in healthy adults using a 3 Tesla magnetic resonance scanner and voxel-based morphometry (VBM).
Methods
T1-weighted magnetic resonance images were obtained in 1,169 healthy adults. The T1-weighted images in native space were bias-corrected, spatially normalized, and segmented into gray matter, white matter, and cerebrospinal fluid images with Statistical Parametric Mapping 5. To investigate regionally the specific effects of the WMS-R-verbal score on the gray matter images, simple regression analysis was performed by VBM treating age, total intracranial volume, and gender as confounding covariates. A
P
value of less than 0.05 corrected with false discovery rate in voxel difference was considered to be statistically significant.
Results
Our study showed a significant positive correlation between the WMS-R-verbal score and the bilateral entorhinal cortex volume. In the right entorhinal,
T
value is 4.75, and the size of the clusters is 155 voxels. In the left entorhinal,
T
value is 4.08, and the size of the clusters is 23 voxels. A significant negative correlation was not found.
Conclusion
To our knowledge, this is the first VBM study showing that entorhinal cortex volume is positively correlated with the WMS-R-verbal score for healthy subjects. Therefore, in our structural neuroimaging study, we add evidence to the hypothesis that the entorhinal cortex is involved in verbal memory processing. |
| doi_str_mv | 10.1007/s00234-011-0863-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_883033512</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2401597411</sourcerecordid><originalsourceid>FETCH-LOGICAL-c432t-ad1dff550e2b41b122a4c827c3d89feb3e7512824e5f6b3ae9bf5487a1b060113</originalsourceid><addsrcrecordid>eNqFkV2L1DAUhoMo7rj6A7yRIIhXdfPVpr2UZdWFXYR1xcuSpifbDGkzJuno_Bl_qymddUEQbxI45znv-XgReknJO0qIPIuEMC4KQmlB6ooX9BHaUMFZQRtGHqNNTtcFbwQ5Qc9i3BJCuOTyKTphVJSlpM0G_bqYkg-DnZTD2ocEP_Heu3kEPIKKc4Ae_7BpwPwWX99cYhvxzkeb7B7cYSkI4FS6h9IA-BvoIToI-BpGHw74i1YOihvY25gx5-9sDpztIXS547gyMQsBNj7gAZRLQ47M3RZ0is_RE6NchBfH_xR9_XBxe_6puPr88fL8_VWh87qpUD3tjSlLAqwTtKOMKaFrJjXv68ZAx0GWlNVMQGmqjitoOlOKWirakSqfj5-it6vuLvjvM8TUjjZqcE5N4OfY1jUnnGeN_5My9y3zk8nXf5FbP4d86AWSdVVJITJEV0gHH2MA0-6CHVU4tJS0i8ntanKbp2wXk9tl2FdH4bkbof9Tce9qBt4cARXztU1Qk7bxgRNcEkZJ5tjKxZya7iA8TPjv7r8BxeLAsg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>877866744</pqid></control><display><type>article</type><title>Entorhinal cortex volume measured with 3T MRI is positively correlated with the Wechsler Memory Scale-Revised logical/verbal memory score for healthy subjects</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Goto, Masami ; Abe, Osamu ; Miyati, Tosiaki ; Yoshikawa, Takeharu ; Hayashi, Naoto ; Takao, Hidemasa ; Inano, Sachiko ; Kabasawa, Hiroyuki ; Mori, Harushi ; Kunimatsu, Akira ; Aoki, Shigeki ; Ino, Kenji ; Iida, Kyouhito ; Yano, Keiichi ; Ohtomo, Kuni</creator><creatorcontrib>Goto, Masami ; Abe, Osamu ; Miyati, Tosiaki ; Yoshikawa, Takeharu ; Hayashi, Naoto ; Takao, Hidemasa ; Inano, Sachiko ; Kabasawa, Hiroyuki ; Mori, Harushi ; Kunimatsu, Akira ; Aoki, Shigeki ; Ino, Kenji ; Iida, Kyouhito ; Yano, Keiichi ; Ohtomo, Kuni</creatorcontrib><description>Introduction
Previous studies revealed a correlation between local brain volume and cognitive function. The aim of the present study was to investigate the correlation between local gray matter volume and the Wechsler Memory Scale-Revised (WMS-R) logical/verbal memory (WMS-R-verbal) score in healthy adults using a 3 Tesla magnetic resonance scanner and voxel-based morphometry (VBM).
Methods
T1-weighted magnetic resonance images were obtained in 1,169 healthy adults. The T1-weighted images in native space were bias-corrected, spatially normalized, and segmented into gray matter, white matter, and cerebrospinal fluid images with Statistical Parametric Mapping 5. To investigate regionally the specific effects of the WMS-R-verbal score on the gray matter images, simple regression analysis was performed by VBM treating age, total intracranial volume, and gender as confounding covariates. A
P
value of less than 0.05 corrected with false discovery rate in voxel difference was considered to be statistically significant.
Results
Our study showed a significant positive correlation between the WMS-R-verbal score and the bilateral entorhinal cortex volume. In the right entorhinal,
T
value is 4.75, and the size of the clusters is 155 voxels. In the left entorhinal,
T
value is 4.08, and the size of the clusters is 23 voxels. A significant negative correlation was not found.
Conclusion
To our knowledge, this is the first VBM study showing that entorhinal cortex volume is positively correlated with the WMS-R-verbal score for healthy subjects. Therefore, in our structural neuroimaging study, we add evidence to the hypothesis that the entorhinal cortex is involved in verbal memory processing.</description><identifier>ISSN: 0028-3940</identifier><identifier>EISSN: 1432-1920</identifier><identifier>DOI: 10.1007/s00234-011-0863-1</identifier><identifier>PMID: 21455719</identifier><identifier>CODEN: NRDYAB</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Brain ; Correlation analysis ; Entorhinal Cortex - anatomy & histology ; Female ; Functional Neuroradiology ; Fundamental and applied biological sciences. Psychology ; Human ; Humans ; Imaging ; Imaging, Three-Dimensional - methods ; Investigative techniques, diagnostic techniques (general aspects) ; Learning. Memory ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Memory ; Middle Aged ; Nervous system ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; NMR ; Nuclear magnetic resonance ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Radiology ; Reference Values ; Reproducibility of Results ; Sensitivity and Specificity ; Statistics as Topic ; Volume ; Wechsler Scales</subject><ispartof>Neuroradiology, 2011-08, Vol.53 (8), p.617-622</ispartof><rights>Springer-Verlag 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-ad1dff550e2b41b122a4c827c3d89feb3e7512824e5f6b3ae9bf5487a1b060113</citedby><cites>FETCH-LOGICAL-c432t-ad1dff550e2b41b122a4c827c3d89feb3e7512824e5f6b3ae9bf5487a1b060113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00234-011-0863-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00234-011-0863-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24370210$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21455719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goto, Masami</creatorcontrib><creatorcontrib>Abe, Osamu</creatorcontrib><creatorcontrib>Miyati, Tosiaki</creatorcontrib><creatorcontrib>Yoshikawa, Takeharu</creatorcontrib><creatorcontrib>Hayashi, Naoto</creatorcontrib><creatorcontrib>Takao, Hidemasa</creatorcontrib><creatorcontrib>Inano, Sachiko</creatorcontrib><creatorcontrib>Kabasawa, Hiroyuki</creatorcontrib><creatorcontrib>Mori, Harushi</creatorcontrib><creatorcontrib>Kunimatsu, Akira</creatorcontrib><creatorcontrib>Aoki, Shigeki</creatorcontrib><creatorcontrib>Ino, Kenji</creatorcontrib><creatorcontrib>Iida, Kyouhito</creatorcontrib><creatorcontrib>Yano, Keiichi</creatorcontrib><creatorcontrib>Ohtomo, Kuni</creatorcontrib><title>Entorhinal cortex volume measured with 3T MRI is positively correlated with the Wechsler Memory Scale-Revised logical/verbal memory score for healthy subjects</title><title>Neuroradiology</title><addtitle>Neuroradiology</addtitle><addtitle>Neuroradiology</addtitle><description>Introduction
Previous studies revealed a correlation between local brain volume and cognitive function. The aim of the present study was to investigate the correlation between local gray matter volume and the Wechsler Memory Scale-Revised (WMS-R) logical/verbal memory (WMS-R-verbal) score in healthy adults using a 3 Tesla magnetic resonance scanner and voxel-based morphometry (VBM).
Methods
T1-weighted magnetic resonance images were obtained in 1,169 healthy adults. The T1-weighted images in native space were bias-corrected, spatially normalized, and segmented into gray matter, white matter, and cerebrospinal fluid images with Statistical Parametric Mapping 5. To investigate regionally the specific effects of the WMS-R-verbal score on the gray matter images, simple regression analysis was performed by VBM treating age, total intracranial volume, and gender as confounding covariates. A
P
value of less than 0.05 corrected with false discovery rate in voxel difference was considered to be statistically significant.
Results
Our study showed a significant positive correlation between the WMS-R-verbal score and the bilateral entorhinal cortex volume. In the right entorhinal,
T
value is 4.75, and the size of the clusters is 155 voxels. In the left entorhinal,
T
value is 4.08, and the size of the clusters is 23 voxels. A significant negative correlation was not found.
Conclusion
To our knowledge, this is the first VBM study showing that entorhinal cortex volume is positively correlated with the WMS-R-verbal score for healthy subjects. Therefore, in our structural neuroimaging study, we add evidence to the hypothesis that the entorhinal cortex is involved in verbal memory processing.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Correlation analysis</subject><subject>Entorhinal Cortex - anatomy & histology</subject><subject>Female</subject><subject>Functional Neuroradiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human</subject><subject>Humans</subject><subject>Imaging</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Learning. Memory</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Memory</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Radiology</subject><subject>Reference Values</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Statistics as Topic</subject><subject>Volume</subject><subject>Wechsler Scales</subject><issn>0028-3940</issn><issn>1432-1920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkV2L1DAUhoMo7rj6A7yRIIhXdfPVpr2UZdWFXYR1xcuSpifbDGkzJuno_Bl_qymddUEQbxI45znv-XgReknJO0qIPIuEMC4KQmlB6ooX9BHaUMFZQRtGHqNNTtcFbwQ5Qc9i3BJCuOTyKTphVJSlpM0G_bqYkg-DnZTD2ocEP_Heu3kEPIKKc4Ae_7BpwPwWX99cYhvxzkeb7B7cYSkI4FS6h9IA-BvoIToI-BpGHw74i1YOihvY25gx5-9sDpztIXS547gyMQsBNj7gAZRLQ47M3RZ0is_RE6NchBfH_xR9_XBxe_6puPr88fL8_VWh87qpUD3tjSlLAqwTtKOMKaFrJjXv68ZAx0GWlNVMQGmqjitoOlOKWirakSqfj5-it6vuLvjvM8TUjjZqcE5N4OfY1jUnnGeN_5My9y3zk8nXf5FbP4d86AWSdVVJITJEV0gHH2MA0-6CHVU4tJS0i8ntanKbp2wXk9tl2FdH4bkbof9Tce9qBt4cARXztU1Qk7bxgRNcEkZJ5tjKxZya7iA8TPjv7r8BxeLAsg</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Goto, Masami</creator><creator>Abe, Osamu</creator><creator>Miyati, Tosiaki</creator><creator>Yoshikawa, Takeharu</creator><creator>Hayashi, Naoto</creator><creator>Takao, Hidemasa</creator><creator>Inano, Sachiko</creator><creator>Kabasawa, Hiroyuki</creator><creator>Mori, Harushi</creator><creator>Kunimatsu, Akira</creator><creator>Aoki, Shigeki</creator><creator>Ino, Kenji</creator><creator>Iida, Kyouhito</creator><creator>Yano, Keiichi</creator><creator>Ohtomo, Kuni</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20110801</creationdate><title>Entorhinal cortex volume measured with 3T MRI is positively correlated with the Wechsler Memory Scale-Revised logical/verbal memory score for healthy subjects</title><author>Goto, Masami ; Abe, Osamu ; Miyati, Tosiaki ; Yoshikawa, Takeharu ; Hayashi, Naoto ; Takao, Hidemasa ; Inano, Sachiko ; Kabasawa, Hiroyuki ; Mori, Harushi ; Kunimatsu, Akira ; Aoki, Shigeki ; Ino, Kenji ; Iida, Kyouhito ; Yano, Keiichi ; Ohtomo, Kuni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-ad1dff550e2b41b122a4c827c3d89feb3e7512824e5f6b3ae9bf5487a1b060113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Correlation analysis</topic><topic>Entorhinal Cortex - anatomy & histology</topic><topic>Female</topic><topic>Functional Neuroradiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human</topic><topic>Humans</topic><topic>Imaging</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Learning. Memory</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Memory</topic><topic>Middle Aged</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Radiology</topic><topic>Reference Values</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Statistics as Topic</topic><topic>Volume</topic><topic>Wechsler Scales</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goto, Masami</creatorcontrib><creatorcontrib>Abe, Osamu</creatorcontrib><creatorcontrib>Miyati, Tosiaki</creatorcontrib><creatorcontrib>Yoshikawa, Takeharu</creatorcontrib><creatorcontrib>Hayashi, Naoto</creatorcontrib><creatorcontrib>Takao, Hidemasa</creatorcontrib><creatorcontrib>Inano, Sachiko</creatorcontrib><creatorcontrib>Kabasawa, Hiroyuki</creatorcontrib><creatorcontrib>Mori, Harushi</creatorcontrib><creatorcontrib>Kunimatsu, Akira</creatorcontrib><creatorcontrib>Aoki, Shigeki</creatorcontrib><creatorcontrib>Ino, Kenji</creatorcontrib><creatorcontrib>Iida, Kyouhito</creatorcontrib><creatorcontrib>Yano, Keiichi</creatorcontrib><creatorcontrib>Ohtomo, Kuni</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroradiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goto, Masami</au><au>Abe, Osamu</au><au>Miyati, Tosiaki</au><au>Yoshikawa, Takeharu</au><au>Hayashi, Naoto</au><au>Takao, Hidemasa</au><au>Inano, Sachiko</au><au>Kabasawa, Hiroyuki</au><au>Mori, Harushi</au><au>Kunimatsu, Akira</au><au>Aoki, Shigeki</au><au>Ino, Kenji</au><au>Iida, Kyouhito</au><au>Yano, Keiichi</au><au>Ohtomo, Kuni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Entorhinal cortex volume measured with 3T MRI is positively correlated with the Wechsler Memory Scale-Revised logical/verbal memory score for healthy subjects</atitle><jtitle>Neuroradiology</jtitle><stitle>Neuroradiology</stitle><addtitle>Neuroradiology</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>53</volume><issue>8</issue><spage>617</spage><epage>622</epage><pages>617-622</pages><issn>0028-3940</issn><eissn>1432-1920</eissn><coden>NRDYAB</coden><abstract>Introduction
Previous studies revealed a correlation between local brain volume and cognitive function. The aim of the present study was to investigate the correlation between local gray matter volume and the Wechsler Memory Scale-Revised (WMS-R) logical/verbal memory (WMS-R-verbal) score in healthy adults using a 3 Tesla magnetic resonance scanner and voxel-based morphometry (VBM).
Methods
T1-weighted magnetic resonance images were obtained in 1,169 healthy adults. The T1-weighted images in native space were bias-corrected, spatially normalized, and segmented into gray matter, white matter, and cerebrospinal fluid images with Statistical Parametric Mapping 5. To investigate regionally the specific effects of the WMS-R-verbal score on the gray matter images, simple regression analysis was performed by VBM treating age, total intracranial volume, and gender as confounding covariates. A
P
value of less than 0.05 corrected with false discovery rate in voxel difference was considered to be statistically significant.
Results
Our study showed a significant positive correlation between the WMS-R-verbal score and the bilateral entorhinal cortex volume. In the right entorhinal,
T
value is 4.75, and the size of the clusters is 155 voxels. In the left entorhinal,
T
value is 4.08, and the size of the clusters is 23 voxels. A significant negative correlation was not found.
Conclusion
To our knowledge, this is the first VBM study showing that entorhinal cortex volume is positively correlated with the WMS-R-verbal score for healthy subjects. Therefore, in our structural neuroimaging study, we add evidence to the hypothesis that the entorhinal cortex is involved in verbal memory processing.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21455719</pmid><doi>10.1007/s00234-011-0863-1</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-3940 |
| ispartof | Neuroradiology, 2011-08, Vol.53 (8), p.617-622 |
| issn | 0028-3940 1432-1920 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_883033512 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Brain Correlation analysis Entorhinal Cortex - anatomy & histology Female Functional Neuroradiology Fundamental and applied biological sciences. Psychology Human Humans Imaging Imaging, Three-Dimensional - methods Investigative techniques, diagnostic techniques (general aspects) Learning. Memory Magnetic Resonance Imaging - methods Male Medical sciences Medicine Medicine & Public Health Memory Middle Aged Nervous system Neurology Neuroradiology Neurosciences Neurosurgery NMR Nuclear magnetic resonance Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Radiodiagnosis. Nmr imagery. Nmr spectrometry Radiology Reference Values Reproducibility of Results Sensitivity and Specificity Statistics as Topic Volume Wechsler Scales |
| title | Entorhinal cortex volume measured with 3T MRI is positively correlated with the Wechsler Memory Scale-Revised logical/verbal memory score for healthy subjects |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T14%3A26%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Entorhinal%20cortex%20volume%20measured%20with%203T%20MRI%20is%20positively%20correlated%20with%20the%20Wechsler%20Memory%20Scale-Revised%20logical/verbal%20memory%20score%20for%20healthy%20subjects&rft.jtitle=Neuroradiology&rft.au=Goto,%20Masami&rft.date=2011-08-01&rft.volume=53&rft.issue=8&rft.spage=617&rft.epage=622&rft.pages=617-622&rft.issn=0028-3940&rft.eissn=1432-1920&rft.coden=NRDYAB&rft_id=info:doi/10.1007/s00234-011-0863-1&rft_dat=%3Cproquest_cross%3E2401597411%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=877866744&rft_id=info:pmid/21455719&rfr_iscdi=true |