Conformational consequences of cooperative binding of a coiled-coil peptide motif to poly(N-(2-hydroxypropyl) methacrylamide) HPMA copolymers

Small-angle neutron scattering and pulsed-gradient spin-echo NMR have been used to examine the solution conformation of a series of water soluble poly( N-(2-hydroxypropyl) methacrylamide) P(HPMA) co-polymer drug delivery vehicles incorporating a coiled-coil peptide motif as a novel pH sensitive non-...

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Veröffentlicht in:Journal of controlled release 2011-07, Vol.153 (2), p.173-179
Hauptverfasser: Griffiths, Peter C., Paul, Alison, Apostolovic, Bojana, Klok, Harm-Anton, de Luca, Edoardo, King, Stephen M., Heenan, Richard K.
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Sprache:eng
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