Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus

In the present study we analyzed aquaporin‐4 (AQP4) immunoreactivity in the piriform cortex (PC) and the hippocampus of pilocarpine‐induced rat epilepsy model to elucidate the roles of AQP4 in brain edema following status epilepticus (SE). In non‐SE‐induced animals, AQP4 immunoreactivity was diffuse...

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Veröffentlicht in:	Journal of comparative neurology (1911) 2010-11, Vol.518 (22), p.4612-4628
Hauptverfasser:	Kim, Ji-Eun, Yeo, Seong-Il, Ryu, Hea Jin, Kim, Min-Ju, Kim, Duk-Soo, Jo, Seung-Mook, Kang, Tae-Cheon
Format:	Artikel
Sprache:	eng
Schlagworte:	acetazolamide Animals Aquaporin 4 Aquaporin 4 - metabolism astrocyte Astrocytes Astrocytes - pathology Brain Brain Edema - etiology Calcium-Binding Proteins - metabolism Cell Count - methods Cerebral Cortex - pathology Cerebral Cortex - physiopathology Cortex (piriform) Disease Models, Animal Dystrophin Dystrophin - metabolism Edema Epilepsy Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Glial Fibrillary Acidic Protein - metabolism Hippocampus Hippocampus - pathology Hippocampus - physiopathology Immunoreactivity Lithium Chloride - toxicity Male Membrane Proteins - metabolism Muscle Proteins - metabolism Pilocarpine - toxicity piriform cortex Rats Rats, Sprague-Dawley Status Epilepticus - chemically induced Status Epilepticus - complications Status Epilepticus - pathology α-syntrophin
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