Variation in GNB3 predicts response and adverse reactions to antidepressants

There is substantial inter-individual variation in response and adverse reactions to antidepressants, and genetic variation may, in part, explain these differences. GNB3 encodes the β3 subunit of the G protein complex, which is involved in the downstream signalling cascade following monoamine recept...

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Veröffentlicht in:	Journal of psychopharmacology (Oxford) 2011-07, Vol.25 (7), p.867-874
Hauptverfasser:	Keers, Robert, Bonvicini, Cristian, Scassellati, Catia, Uher, Rudolf, Placentino, Anna, Giovannini, Caterina, Rietschel, Marcella, Henigsberg, Neven, Kozel, Dejan, Mors, Ole, Maier, Wolfgang, Hauser, Joanna, Souery, Daniel, Mendlewicz, Julien, Schmäl, Christine, Zobel, Astrid, Larsen, Erik R, Szczepankiewicz, Aleksandra, Kovacic, Zrnka, Elkin, Amanda, Craig, Ian, McGuffin, Peter, Farmer, Anne E, Aitchison, Katherine J, Gennarelli, Massimo
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adult Adult and adolescent clinical studies Antidepressants Antidepressive Agents - adverse effects Antidepressive Agents - therapeutic use Appetite Biological and medical sciences Citalopram Citalopram - adverse effects Citalopram - therapeutic use Data processing Depression Depressive Disorder, Major - diagnosis Depressive Disorder, Major - drug therapy Depressive Disorder, Major - genetics Europe Female Functional anatomy Gene Frequency Gene polymorphism Genes Guanine nucleotide-binding protein Haplotypes Heterotrimeric GTP-Binding Proteins - genetics Humans Insomnia Linkage Disequilibrium Male Medical sciences Mental depression Middle Aged Mood Mood disorders Neuropharmacology Nortriptyline - adverse effects Nortriptyline - therapeutic use Pharmacogenetics Pharmacogenomics Pharmacology. Drug treatments Polymorphism, Single Nucleotide Psychiatric Status Rating Scales Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Receptor mechanisms Risk Assessment Risk Factors Side effects Single-nucleotide polymorphism Sleep disorders Sleep Initiation and Maintenance Disorders - chemically induced Time Factors Transcription Treatment Outcome Weight Gain - drug effects
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