Effects of a calcineurin inhibitor, FK506, and a CCR5/CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model

Abstract The effects of FK506, and TAK-779, antagonists of CCR5 and CXCR3, were investigated using a rat intestinal transplantation model. Small intestines from DA rats were heterotopically transplanted into LEW rats. The recipients were treated with FK506 (1 mg/kg/day, day 0–5) and TAK-779 (10 mg/k...

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Veröffentlicht in:	Transplant immunology 2011-07, Vol.25 (1), p.49-55
Hauptverfasser:	Takama, Yuichi, Miyagawa, Shuji, Yamamoto, Aki, Firdawes, Sabere, Ueno, Takehisa, Ihara, Yoshiyuki, Kondo, Akihiro, Matsunami, Katsuyoshi, Otsuka, Hideaki, Fukuzawa, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Amides - pharmacology Animals Calcineurin - immunology Calcineurin Inhibitors CCR5 CCR5 Receptor Antagonists CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cell Proliferation - drug effects CXCR3 FK506 Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Graft Rejection - drug therapy Graft Rejection - immunology Graft Survival - drug effects Graft Survival - immunology Immunosuppressive Agents - pharmacology Interferon-gamma - immunology Intestine, Small - transplantation Models, Biological Peyer's Patches - immunology Quaternary Ammonium Compounds - pharmacology Rat intestinal transplantation Rats Rats, Inbred Lew Receptors, CCR5 - immunology Receptors, CXCR3 - antagonists & inhibitors Receptors, CXCR3 - immunology Tacrolimus - pharmacology TAK-779 Transplantation, Homologous
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