Acridine derivatives as anti-BVDV agents
Twenty-six 9-aminoacridine derivatives were evaluated in cell-based assays for cytotoxicity and antiviral activity against a panel of 10 RNA and DNA viruses. While seven compounds ( 9, 10, 14, 19, 21, 22, 24) did not affect any virus and two ( 6, 11) were moderately active against CVB-5 or Reo-1, 17...
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| Veröffentlicht in: | Antiviral research 2011-08, Vol.91 (2), p.133-141 |
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| creator | Tonelli, Michele Vettoretti, Gerolamo Tasso, Bruno Novelli, Federica Boido, Vito Sparatore, Fabio Busonera, Bernardetta Ouhtit, Aicha Farci, Pamela Blois, Sylvain Giliberti, Gabriele La Colla, Paolo |
| description | Twenty-six 9-aminoacridine derivatives were evaluated in cell-based assays for cytotoxicity and antiviral activity against a panel of 10 RNA and DNA viruses. While seven compounds (
9,
10,
14,
19,
21,
22,
24) did not affect any virus and two (
6,
11) were moderately active against CVB-5 or Reo-1, 17 compounds exhibited a marked specific activity against BVDV, prototype of pestiviruses which are responsible for severe diseases of livestock. Most anti-BVDV agents showed EC
50 values in the range 0.1–8
μM, thus comparing favorably with the reference drugs ribavirine and NM 108. Some compounds, particularly those bearing a quinolizidinylalkyl side chain, displayed pronounced cytotoxicity. Further studies are warranted in order to achieve still better anti-BVDV agents, and to explore the potential antiproliferative activity of this kind of compounds. |
| doi_str_mv | 10.1016/j.antiviral.2011.05.005 |
| format | Article |
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9,
10,
14,
19,
21,
22,
24) did not affect any virus and two (
6,
11) were moderately active against CVB-5 or Reo-1, 17 compounds exhibited a marked specific activity against BVDV, prototype of pestiviruses which are responsible for severe diseases of livestock. Most anti-BVDV agents showed EC
50 values in the range 0.1–8
μM, thus comparing favorably with the reference drugs ribavirine and NM 108. Some compounds, particularly those bearing a quinolizidinylalkyl side chain, displayed pronounced cytotoxicity. Further studies are warranted in order to achieve still better anti-BVDV agents, and to explore the potential antiproliferative activity of this kind of compounds.</description><identifier>ISSN: 0166-3542</identifier><identifier>EISSN: 1872-9096</identifier><identifier>DOI: 10.1016/j.antiviral.2011.05.005</identifier><identifier>PMID: 21619897</identifier><identifier>CODEN: ARSRDR</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>9-Aminoacridine derivatives ; Acridines - chemical synthesis ; Acridines - chemistry ; Acridines - pharmacology ; Aminoacridines - chemistry ; Aminoacridines - pharmacology ; Animals ; Anti-BVDV activity ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Antiviral Agents - chemical synthesis ; Antiviral Agents - chemistry ; Antiviral Agents - pharmacology ; Biological and medical sciences ; Bovine viral diarrhea virus ; Cell Line ; Diarrhea Viruses, Bovine Viral - drug effects ; Dimethyl Sulfoxide - chemistry ; DNA Viruses - drug effects ; Humans ; Linear Models ; Medical sciences ; Microbial Sensitivity Tests ; Molecular Structure ; Pharmacology. Drug treatments ; RNA and DNA viruses ; RNA Viruses - drug effects</subject><ispartof>Antiviral research, 2011-08, Vol.91 (2), p.133-141</ispartof><rights>2011 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-aefb7a42c767cea9be19b0c7a99fd0b32c2713fc65baa4780175f29bd068e91e3</citedby><cites>FETCH-LOGICAL-c432t-aefb7a42c767cea9be19b0c7a99fd0b32c2713fc65baa4780175f29bd068e91e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.antiviral.2011.05.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24340577$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21619897$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tonelli, Michele</creatorcontrib><creatorcontrib>Vettoretti, Gerolamo</creatorcontrib><creatorcontrib>Tasso, Bruno</creatorcontrib><creatorcontrib>Novelli, Federica</creatorcontrib><creatorcontrib>Boido, Vito</creatorcontrib><creatorcontrib>Sparatore, Fabio</creatorcontrib><creatorcontrib>Busonera, Bernardetta</creatorcontrib><creatorcontrib>Ouhtit, Aicha</creatorcontrib><creatorcontrib>Farci, Pamela</creatorcontrib><creatorcontrib>Blois, Sylvain</creatorcontrib><creatorcontrib>Giliberti, Gabriele</creatorcontrib><creatorcontrib>La Colla, Paolo</creatorcontrib><title>Acridine derivatives as anti-BVDV agents</title><title>Antiviral research</title><addtitle>Antiviral Res</addtitle><description>Twenty-six 9-aminoacridine derivatives were evaluated in cell-based assays for cytotoxicity and antiviral activity against a panel of 10 RNA and DNA viruses. While seven compounds (
9,
10,
14,
19,
21,
22,
24) did not affect any virus and two (
6,
11) were moderately active against CVB-5 or Reo-1, 17 compounds exhibited a marked specific activity against BVDV, prototype of pestiviruses which are responsible for severe diseases of livestock. Most anti-BVDV agents showed EC
50 values in the range 0.1–8
μM, thus comparing favorably with the reference drugs ribavirine and NM 108. Some compounds, particularly those bearing a quinolizidinylalkyl side chain, displayed pronounced cytotoxicity. Further studies are warranted in order to achieve still better anti-BVDV agents, and to explore the potential antiproliferative activity of this kind of compounds.</description><subject>9-Aminoacridine derivatives</subject><subject>Acridines - chemical synthesis</subject><subject>Acridines - chemistry</subject><subject>Acridines - pharmacology</subject><subject>Aminoacridines - chemistry</subject><subject>Aminoacridines - pharmacology</subject><subject>Animals</subject><subject>Anti-BVDV activity</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Antiviral Agents - chemical synthesis</subject><subject>Antiviral Agents - chemistry</subject><subject>Antiviral Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bovine viral diarrhea virus</subject><subject>Cell Line</subject><subject>Diarrhea Viruses, Bovine Viral - drug effects</subject><subject>Dimethyl Sulfoxide - chemistry</subject><subject>DNA Viruses - drug effects</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Structure</subject><subject>Pharmacology. Drug treatments</subject><subject>RNA and DNA viruses</subject><subject>RNA Viruses - drug effects</subject><issn>0166-3542</issn><issn>1872-9096</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PwzAMhiMEgvHxF2AXBJcWJ23zcRzfSJO4wK6Rm7ooU9dB0k3i3xO0AUckS748fm0_jJ1xyDlweTXPsR_82gfscgGc51DlANUOG3GtRGbAyF02SqTMiqoUB-wwxjkASGX0PjsQXHKjjRqxy4kLvvE9jRsKfo0plOIYU6X87Hp2OxvjG_VDPGZ7LXaRTrb9iL3e373cPGbT54enm8k0c2UhhgyprRWWwimpHKGpiZsanEJj2gbqQjiheNE6WdWIpdLAVdUKUzcgNRlOxRG72OS-h-XHiuJgFz466jrsabmKVusCivRq-T-ppK6U0iqRakO6sIwxUGvfg19g-LQc7LdPO7e_Pu23TwuVTUvS5Ol2x6peUPM79yMwAedbAKPDrg3YOx__uLIoIR2RuMmGo-Ru7SnY6Dz1jhofyA22Wfp_j_kCxdCWjA</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Tonelli, Michele</creator><creator>Vettoretti, Gerolamo</creator><creator>Tasso, Bruno</creator><creator>Novelli, Federica</creator><creator>Boido, Vito</creator><creator>Sparatore, Fabio</creator><creator>Busonera, Bernardetta</creator><creator>Ouhtit, Aicha</creator><creator>Farci, Pamela</creator><creator>Blois, Sylvain</creator><creator>Giliberti, Gabriele</creator><creator>La Colla, Paolo</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20110801</creationdate><title>Acridine derivatives as anti-BVDV agents</title><author>Tonelli, Michele ; Vettoretti, Gerolamo ; Tasso, Bruno ; Novelli, Federica ; Boido, Vito ; Sparatore, Fabio ; Busonera, Bernardetta ; Ouhtit, Aicha ; Farci, Pamela ; Blois, Sylvain ; Giliberti, Gabriele ; La Colla, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-aefb7a42c767cea9be19b0c7a99fd0b32c2713fc65baa4780175f29bd068e91e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>9-Aminoacridine derivatives</topic><topic>Acridines - chemical synthesis</topic><topic>Acridines - chemistry</topic><topic>Acridines - pharmacology</topic><topic>Aminoacridines - chemistry</topic><topic>Aminoacridines - pharmacology</topic><topic>Animals</topic><topic>Anti-BVDV activity</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Antiviral Agents - chemical synthesis</topic><topic>Antiviral Agents - chemistry</topic><topic>Antiviral Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bovine viral diarrhea virus</topic><topic>Cell Line</topic><topic>Diarrhea Viruses, Bovine Viral - drug effects</topic><topic>Dimethyl Sulfoxide - chemistry</topic><topic>DNA Viruses - drug effects</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular Structure</topic><topic>Pharmacology. Drug treatments</topic><topic>RNA and DNA viruses</topic><topic>RNA Viruses - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tonelli, Michele</creatorcontrib><creatorcontrib>Vettoretti, Gerolamo</creatorcontrib><creatorcontrib>Tasso, Bruno</creatorcontrib><creatorcontrib>Novelli, Federica</creatorcontrib><creatorcontrib>Boido, Vito</creatorcontrib><creatorcontrib>Sparatore, Fabio</creatorcontrib><creatorcontrib>Busonera, Bernardetta</creatorcontrib><creatorcontrib>Ouhtit, Aicha</creatorcontrib><creatorcontrib>Farci, Pamela</creatorcontrib><creatorcontrib>Blois, Sylvain</creatorcontrib><creatorcontrib>Giliberti, Gabriele</creatorcontrib><creatorcontrib>La Colla, Paolo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Antiviral research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tonelli, Michele</au><au>Vettoretti, Gerolamo</au><au>Tasso, Bruno</au><au>Novelli, Federica</au><au>Boido, Vito</au><au>Sparatore, Fabio</au><au>Busonera, Bernardetta</au><au>Ouhtit, Aicha</au><au>Farci, Pamela</au><au>Blois, Sylvain</au><au>Giliberti, Gabriele</au><au>La Colla, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acridine derivatives as anti-BVDV agents</atitle><jtitle>Antiviral research</jtitle><addtitle>Antiviral Res</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>91</volume><issue>2</issue><spage>133</spage><epage>141</epage><pages>133-141</pages><issn>0166-3542</issn><eissn>1872-9096</eissn><coden>ARSRDR</coden><abstract>Twenty-six 9-aminoacridine derivatives were evaluated in cell-based assays for cytotoxicity and antiviral activity against a panel of 10 RNA and DNA viruses. While seven compounds (
9,
10,
14,
19,
21,
22,
24) did not affect any virus and two (
6,
11) were moderately active against CVB-5 or Reo-1, 17 compounds exhibited a marked specific activity against BVDV, prototype of pestiviruses which are responsible for severe diseases of livestock. Most anti-BVDV agents showed EC
50 values in the range 0.1–8
μM, thus comparing favorably with the reference drugs ribavirine and NM 108. Some compounds, particularly those bearing a quinolizidinylalkyl side chain, displayed pronounced cytotoxicity. Further studies are warranted in order to achieve still better anti-BVDV agents, and to explore the potential antiproliferative activity of this kind of compounds.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>21619897</pmid><doi>10.1016/j.antiviral.2011.05.005</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0166-3542 |
| ispartof | Antiviral research, 2011-08, Vol.91 (2), p.133-141 |
| issn | 0166-3542 1872-9096 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 9-Aminoacridine derivatives Acridines - chemical synthesis Acridines - chemistry Acridines - pharmacology Aminoacridines - chemistry Aminoacridines - pharmacology Animals Anti-BVDV activity Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Bovine viral diarrhea virus Cell Line Diarrhea Viruses, Bovine Viral - drug effects Dimethyl Sulfoxide - chemistry DNA Viruses - drug effects Humans Linear Models Medical sciences Microbial Sensitivity Tests Molecular Structure Pharmacology. Drug treatments RNA and DNA viruses RNA Viruses - drug effects |
| title | Acridine derivatives as anti-BVDV agents |
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