The level of arousal modulates P50 peak amplitude
► P50 amplitude to S1 is higher in the low arousal closed eyes condition. ► P50 amplitude to S2 and gating measures are not affected by the level of arousal. ► Arousal level has to be evaluated during P50 studies and data interpretation. We aimed to evaluate the effect of arousal level in healthy su...
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| Veröffentlicht in: | Neuroscience letters 2011-07, Vol.499 (3), p.204-207 |
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| container_title | Neuroscience letters |
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| creator | Griskova-Bulanova, Inga Paskevic, Jevgenij Dapsys, Kastytis Maciulis, Valentinas Ruksenas, Osvaldas Arnfred, Sidse M. |
| description | ► P50 amplitude to S1 is higher in the low arousal closed eyes condition.
► P50 amplitude to S2 and gating measures are not affected by the level of arousal.
► Arousal level has to be evaluated during P50 studies and data interpretation.
We aimed to evaluate the effect of arousal level in healthy subjects on P50 potential, as the variation in the level of arousal may be a source of variance in the recordings as well as it may provide additional information about the pathology under study. Eleven healthy volunteers participated in the study. A standard auditory P50 potential paradigm was applied. Two stimulation conditions were selected: eyes-open, i.e., high arousal level condition and eyes-closed, i.e., low arousal level condition. P50 component amplitudes in response to both the first (S1) and second stimulus (S2) of the pair, their ratio and difference were evaluated. P50 amplitude in response to S1 was significantly higher during the low arousal closed eyes condition as compared to high arousal open eyes condition. There was no P50 amplitude difference in response to S2 and no arousal effect on gating measures. This prompts for more careful evaluation of patients’ arousal level when performing P50 studies and interpreting the results. |
| doi_str_mv | 10.1016/j.neulet.2011.05.062 |
| format | Article |
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► P50 amplitude to S2 and gating measures are not affected by the level of arousal.
► Arousal level has to be evaluated during P50 studies and data interpretation.
We aimed to evaluate the effect of arousal level in healthy subjects on P50 potential, as the variation in the level of arousal may be a source of variance in the recordings as well as it may provide additional information about the pathology under study. Eleven healthy volunteers participated in the study. A standard auditory P50 potential paradigm was applied. Two stimulation conditions were selected: eyes-open, i.e., high arousal level condition and eyes-closed, i.e., low arousal level condition. P50 component amplitudes in response to both the first (S1) and second stimulus (S2) of the pair, their ratio and difference were evaluated. P50 amplitude in response to S1 was significantly higher during the low arousal closed eyes condition as compared to high arousal open eyes condition. There was no P50 amplitude difference in response to S2 and no arousal effect on gating measures. This prompts for more careful evaluation of patients’ arousal level when performing P50 studies and interpreting the results.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2011.05.062</identifier><identifier>PMID: 21664254</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acoustic Stimulation - methods ; Adult ; Amplitude ; Arousal ; Arousal - physiology ; Auditory ; Biological and medical sciences ; Brain Waves - physiology ; Electroencephalography - methods ; Evoked Potentials, Auditory - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; P50 potential ; Sensory Gating ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2011-07, Vol.499 (3), p.204-207</ispartof><rights>2011 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-a6371428b9ee39832a36b0fae022e6d473ffd0b47a6f8ed1ccf814b92ef1c2c93</citedby><cites>FETCH-LOGICAL-c423t-a6371428b9ee39832a36b0fae022e6d473ffd0b47a6f8ed1ccf814b92ef1c2c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394011006884$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24349482$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21664254$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Griskova-Bulanova, Inga</creatorcontrib><creatorcontrib>Paskevic, Jevgenij</creatorcontrib><creatorcontrib>Dapsys, Kastytis</creatorcontrib><creatorcontrib>Maciulis, Valentinas</creatorcontrib><creatorcontrib>Ruksenas, Osvaldas</creatorcontrib><creatorcontrib>Arnfred, Sidse M.</creatorcontrib><title>The level of arousal modulates P50 peak amplitude</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>► P50 amplitude to S1 is higher in the low arousal closed eyes condition.
► P50 amplitude to S2 and gating measures are not affected by the level of arousal.
► Arousal level has to be evaluated during P50 studies and data interpretation.
We aimed to evaluate the effect of arousal level in healthy subjects on P50 potential, as the variation in the level of arousal may be a source of variance in the recordings as well as it may provide additional information about the pathology under study. Eleven healthy volunteers participated in the study. A standard auditory P50 potential paradigm was applied. Two stimulation conditions were selected: eyes-open, i.e., high arousal level condition and eyes-closed, i.e., low arousal level condition. P50 component amplitudes in response to both the first (S1) and second stimulus (S2) of the pair, their ratio and difference were evaluated. P50 amplitude in response to S1 was significantly higher during the low arousal closed eyes condition as compared to high arousal open eyes condition. There was no P50 amplitude difference in response to S2 and no arousal effect on gating measures. This prompts for more careful evaluation of patients’ arousal level when performing P50 studies and interpreting the results.</description><subject>Acoustic Stimulation - methods</subject><subject>Adult</subject><subject>Amplitude</subject><subject>Arousal</subject><subject>Arousal - physiology</subject><subject>Auditory</subject><subject>Biological and medical sciences</subject><subject>Brain Waves - physiology</subject><subject>Electroencephalography - methods</subject><subject>Evoked Potentials, Auditory - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>P50 potential</subject><subject>Sensory Gating</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLw0AUhQdRbK3-A5FsxFXinUcmyUaQ4gsKuqjrYTK5g6mTps4kBf-9Kam609XdfOfcw0fIOYWEApXXq2SNvcMuYUBpAmkCkh2QKc0zFmdFxg7JFDiImBcCJuQkhBUApDQVx2TCqJSCpWJK6PINI4dbdFFrI-3bPmgXNW3VO91hiF5SiDao3yPdbFzd9RWekiOrXcCz_Z2R1_u75fwxXjw_PM1vF7ERjHexljyjguVlgciLnDPNZQlWIzCGshIZt7aCUmRa2hwraozNqSgLhpYaZgo-I1dj78a3Hz2GTjV1MOicXuOwUuU5B1ZwgP_JTA5WBLCBFCNpfBuCR6s2vm60_1QU1M6qWqnRqtpZVZCqweoQu9g_6MsGq5_Qt8YBuNwDOhjtrNdrU4dfTnBRiHxXdDNyOIjb1uhVMDWuDVa1R9Opqq3_XvIF0SqVmw</recordid><startdate>20110725</startdate><enddate>20110725</enddate><creator>Griskova-Bulanova, Inga</creator><creator>Paskevic, Jevgenij</creator><creator>Dapsys, Kastytis</creator><creator>Maciulis, Valentinas</creator><creator>Ruksenas, Osvaldas</creator><creator>Arnfred, Sidse M.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20110725</creationdate><title>The level of arousal modulates P50 peak amplitude</title><author>Griskova-Bulanova, Inga ; Paskevic, Jevgenij ; Dapsys, Kastytis ; Maciulis, Valentinas ; Ruksenas, Osvaldas ; Arnfred, Sidse M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-a6371428b9ee39832a36b0fae022e6d473ffd0b47a6f8ed1ccf814b92ef1c2c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acoustic Stimulation - methods</topic><topic>Adult</topic><topic>Amplitude</topic><topic>Arousal</topic><topic>Arousal - physiology</topic><topic>Auditory</topic><topic>Biological and medical sciences</topic><topic>Brain Waves - physiology</topic><topic>Electroencephalography - methods</topic><topic>Evoked Potentials, Auditory - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>P50 potential</topic><topic>Sensory Gating</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Griskova-Bulanova, Inga</creatorcontrib><creatorcontrib>Paskevic, Jevgenij</creatorcontrib><creatorcontrib>Dapsys, Kastytis</creatorcontrib><creatorcontrib>Maciulis, Valentinas</creatorcontrib><creatorcontrib>Ruksenas, Osvaldas</creatorcontrib><creatorcontrib>Arnfred, Sidse M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Griskova-Bulanova, Inga</au><au>Paskevic, Jevgenij</au><au>Dapsys, Kastytis</au><au>Maciulis, Valentinas</au><au>Ruksenas, Osvaldas</au><au>Arnfred, Sidse M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The level of arousal modulates P50 peak amplitude</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2011-07-25</date><risdate>2011</risdate><volume>499</volume><issue>3</issue><spage>204</spage><epage>207</epage><pages>204-207</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>► P50 amplitude to S1 is higher in the low arousal closed eyes condition.
► P50 amplitude to S2 and gating measures are not affected by the level of arousal.
► Arousal level has to be evaluated during P50 studies and data interpretation.
We aimed to evaluate the effect of arousal level in healthy subjects on P50 potential, as the variation in the level of arousal may be a source of variance in the recordings as well as it may provide additional information about the pathology under study. Eleven healthy volunteers participated in the study. A standard auditory P50 potential paradigm was applied. Two stimulation conditions were selected: eyes-open, i.e., high arousal level condition and eyes-closed, i.e., low arousal level condition. P50 component amplitudes in response to both the first (S1) and second stimulus (S2) of the pair, their ratio and difference were evaluated. P50 amplitude in response to S1 was significantly higher during the low arousal closed eyes condition as compared to high arousal open eyes condition. There was no P50 amplitude difference in response to S2 and no arousal effect on gating measures. This prompts for more careful evaluation of patients’ arousal level when performing P50 studies and interpreting the results.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>21664254</pmid><doi>10.1016/j.neulet.2011.05.062</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acoustic Stimulation - methods Adult Amplitude Arousal Arousal - physiology Auditory Biological and medical sciences Brain Waves - physiology Electroencephalography - methods Evoked Potentials, Auditory - physiology Female Fundamental and applied biological sciences. Psychology Humans Male P50 potential Sensory Gating Vertebrates: nervous system and sense organs |
| title | The level of arousal modulates P50 peak amplitude |
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