Hair follicles as a niche of Staphylococcus aureus in the nose; is a more effective decolonisation strategy needed?
Summary Staphylococcus aureus is the major cause of surgical site infections, and meticillin-resistant S. aureus (MRSA) is increasingly accounting for infections worldwide. Preventing surgical site infections by screening and decolonising positive patients reduces the number of infections, but does...
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| Veröffentlicht in: | The Journal of hospital infection 2010-11, Vol.76 (3), p.211-214 |
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| container_title | The Journal of hospital infection |
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| creator | ten Broeke-Smits, N.J.P Kummer, J.A Bleys, R.L.A.W Fluit, A.C Boel, C.H.E |
| description | Summary Staphylococcus aureus is the major cause of surgical site infections, and meticillin-resistant S. aureus (MRSA) is increasingly accounting for infections worldwide. Preventing surgical site infections by screening and decolonising positive patients reduces the number of infections, but does not completely eradicate the risk. A balance between prevention, costs and the chance of mupirocin-resistant S. aureus needs to be evaluated and decolonisation strategies optimised. It is essential to know the site of S. aureus during colonisation. In this study, for the first time the exact location of S. aureus in the human nose was determined using a histological approach. We showed the presence of S. aureus in the cornified layer of squamous epithelium, associated keratin and mucous debris and within hair follicles in the vestibulum nasi. The presence of S. aureus in hair follicles suggests that this could be the niche from which relapses occur after decolonisation. Decolonisation strategies might have to be reconsidered. |
| doi_str_mv | 10.1016/j.jhin.2010.07.011 |
| format | Article |
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Preventing surgical site infections by screening and decolonising positive patients reduces the number of infections, but does not completely eradicate the risk. A balance between prevention, costs and the chance of mupirocin-resistant S. aureus needs to be evaluated and decolonisation strategies optimised. It is essential to know the site of S. aureus during colonisation. In this study, for the first time the exact location of S. aureus in the human nose was determined using a histological approach. We showed the presence of S. aureus in the cornified layer of squamous epithelium, associated keratin and mucous debris and within hair follicles in the vestibulum nasi. The presence of S. aureus in hair follicles suggests that this could be the niche from which relapses occur after decolonisation. Decolonisation strategies might have to be reconsidered.</description><identifier>ISSN: 0195-6701</identifier><identifier>EISSN: 1532-2939</identifier><identifier>DOI: 10.1016/j.jhin.2010.07.011</identifier><identifier>PMID: 20864209</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Aged ; Aged, 80 and over ; Anti-Bacterial Agents - therapeutic use ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacterial diseases ; Biological and medical sciences ; Carrier State - drug therapy ; Carrier State - microbiology ; Epithelium - microbiology ; Female ; Hair Follicle - microbiology ; Human bacterial diseases ; Humans ; Immunohistochemistry ; Infectious Disease ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Mupirocin ; Nasal colonisation ; Nose - cytology ; Nose - microbiology ; Pharmacology. Drug treatments ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - microbiology ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Staphylococcus aureus ; Staphylococcus aureus - isolation & purification</subject><ispartof>The Journal of hospital infection, 2010-11, Vol.76 (3), p.211-214</ispartof><rights>The Hospital Infection Society</rights><rights>2010 The Hospital Infection Society</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 The Hospital Infection Society. Published by Elsevier Ltd. 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Preventing surgical site infections by screening and decolonising positive patients reduces the number of infections, but does not completely eradicate the risk. A balance between prevention, costs and the chance of mupirocin-resistant S. aureus needs to be evaluated and decolonisation strategies optimised. It is essential to know the site of S. aureus during colonisation. In this study, for the first time the exact location of S. aureus in the human nose was determined using a histological approach. We showed the presence of S. aureus in the cornified layer of squamous epithelium, associated keratin and mucous debris and within hair follicles in the vestibulum nasi. The presence of S. aureus in hair follicles suggests that this could be the niche from which relapses occur after decolonisation. Decolonisation strategies might have to be reconsidered.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Carrier State - drug therapy</subject><subject>Carrier State - microbiology</subject><subject>Epithelium - microbiology</subject><subject>Female</subject><subject>Hair Follicle - microbiology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Infectious Disease</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mupirocin</subject><subject>Nasal colonisation</subject><subject>Nose - cytology</subject><subject>Nose - microbiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - isolation & purification</subject><issn>0195-6701</issn><issn>1532-2939</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkGLFDEQhRtR3HH1D3iQXMTTjJWkk0xQVmRRV1jwsHoO2aTiZMx0xqR7Yf69aWZU8OBCoKDqe0WR97ruOYUVBSpfb1fbTRxWDFoD1AoofdAtqOBsyTTXD7sFUC2WUgE9657UugWA1hePuzMGa9kz0IuuXtlYSMgpRZewEtseGaLbIMmB3Ix2vzmk7LJzU5tMBVuJAxnbfMgV35A4C3a5IMEQ0I3xDolHl1MeYrVjzAOpY7Ejfj-QAdGjf_e0exRsqvjsVM-7bx8_fL28Wl5_-fT58v310gnoxyW_VTY4F5T3njrRW45MCI1Bu15qJqjQXgWtMKCiIIF62YNjMvRhjcJbft69Ou7dl_xzwjqaXawOU7ID5qma9ZoD06DE_aRUqqeawb2kEqoXWgjZSHYkXcm1FgxmX-LOloOhYGb_zNbM_pnZPwPKNP-a6MVp_XS7Q_9H8tuwBrw8AbY6m0Kxg4v1L8e5kr3mjXt75LB98F3EYqqLODj0sTSXjM_x_3dc_CN3KbZY2PQDD1i3eSpDs85QU5kBczMnbQ4abRnjnEv-C8rqzic</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>ten Broeke-Smits, N.J.P</creator><creator>Kummer, J.A</creator><creator>Bleys, R.L.A.W</creator><creator>Fluit, A.C</creator><creator>Boel, C.H.E</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20101101</creationdate><title>Hair follicles as a niche of Staphylococcus aureus in the nose; is a more effective decolonisation strategy needed?</title><author>ten Broeke-Smits, N.J.P ; Kummer, J.A ; Bleys, R.L.A.W ; Fluit, A.C ; Boel, C.H.E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-3b7afccf7ddd1c54a3e2559ef9c46925159d7f97efe710601d640c26f4f8e5da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Carrier State - drug therapy</topic><topic>Carrier State - microbiology</topic><topic>Epithelium - microbiology</topic><topic>Female</topic><topic>Hair Follicle - microbiology</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Infectious Disease</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mupirocin</topic><topic>Nasal colonisation</topic><topic>Nose - cytology</topic><topic>Nose - microbiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcal infections, streptococcal infections, pneumococcal infections</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ten Broeke-Smits, N.J.P</creatorcontrib><creatorcontrib>Kummer, J.A</creatorcontrib><creatorcontrib>Bleys, R.L.A.W</creatorcontrib><creatorcontrib>Fluit, A.C</creatorcontrib><creatorcontrib>Boel, C.H.E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>The Journal of hospital infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ten Broeke-Smits, N.J.P</au><au>Kummer, J.A</au><au>Bleys, R.L.A.W</au><au>Fluit, A.C</au><au>Boel, C.H.E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hair follicles as a niche of Staphylococcus aureus in the nose; is a more effective decolonisation strategy needed?</atitle><jtitle>The Journal of hospital infection</jtitle><addtitle>J Hosp Infect</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>76</volume><issue>3</issue><spage>211</spage><epage>214</epage><pages>211-214</pages><issn>0195-6701</issn><eissn>1532-2939</eissn><abstract>Summary Staphylococcus aureus is the major cause of surgical site infections, and meticillin-resistant S. aureus (MRSA) is increasingly accounting for infections worldwide. Preventing surgical site infections by screening and decolonising positive patients reduces the number of infections, but does not completely eradicate the risk. A balance between prevention, costs and the chance of mupirocin-resistant S. aureus needs to be evaluated and decolonisation strategies optimised. It is essential to know the site of S. aureus during colonisation. In this study, for the first time the exact location of S. aureus in the human nose was determined using a histological approach. We showed the presence of S. aureus in the cornified layer of squamous epithelium, associated keratin and mucous debris and within hair follicles in the vestibulum nasi. The presence of S. aureus in hair follicles suggests that this could be the niche from which relapses occur after decolonisation. Decolonisation strategies might have to be reconsidered.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>20864209</pmid><doi>10.1016/j.jhin.2010.07.011</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial diseases Biological and medical sciences Carrier State - drug therapy Carrier State - microbiology Epithelium - microbiology Female Hair Follicle - microbiology Human bacterial diseases Humans Immunohistochemistry Infectious Disease Infectious diseases Male Medical sciences Middle Aged Mupirocin Nasal colonisation Nose - cytology Nose - microbiology Pharmacology. Drug treatments Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcal infections, streptococcal infections, pneumococcal infections Staphylococcus aureus Staphylococcus aureus - isolation & purification |
| title | Hair follicles as a niche of Staphylococcus aureus in the nose; is a more effective decolonisation strategy needed? |
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