Role of mast cell activation in inducing microglial cells to release neurotrophin

The brain‐derived neurotrophic factor (BDNF) plays a critical role in pain hypersensitivity. BDNF is the ligand of P2X4 receptors (P2X4R) in the microglia. The causative factors involving the P2X4R over expression in the microglia remains unclear. Mast cell activation has a close relation with pain...

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Veröffentlicht in:	Journal of neuroscience research 2010-05, Vol.88 (6), p.1348-1354
Hauptverfasser:	Yuan, Hongbin, Zhu, Xiaoling, Zhou, Shuangqiong, Chen, Qianbo, Zhu, Xiaoxing, Ma, Xue, He, Xingying, Tian, Mouli, Shi, Xueyin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Animals ATP Brain-Derived Neurotrophic Factor - metabolism Cell Line Cells, Cultured Extracellular Signal-Regulated MAP Kinases - metabolism Humans Male mast cells Mast Cells - physiology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Microglia - physiology microglial cells Nerve Growth Factors - metabolism pain hypersensitivity Phosphorylation Receptor, PAR-2 - deficiency Receptor, PAR-2 - genetics Receptor, PAR-2 - metabolism Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2X4 Tryptases - metabolism
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