Preparation of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetami d e derivatives as novel arginine vasopressin V sub(2 receptor agonists)

The present work describes the discovery of novel series of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetam i de derivatives as arginine vasopressin (AVP) V sub(2 receptor agonists. By replacing the amide juncture in YM-35278 with a direct ring connection gave compound 10a, which...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-11, Vol.16 (21), p.9524-9535
Hauptverfasser:	Tsukamoto, Issei, Koshio, Hiroyuki, Akamatsu, Seijiro, Kuramochi, Takahiro, Saitoh, Chikashi, Yatsu, Takeyuki, Yanai-Inamura, Hiroko, Kitada, Chika, Yamamoto, Eisaku, Sakamoto, Shuichi, Tsukamoto, Shin-Ichi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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