Tumor necrosis factor alpha (TNF-α), anti-TNF-α and demyelination revisited: An ongoing story

Abstract Tumor necrosis factor alpha (TNF-α) is a cytokine with pleiotropic actions that can be present both as a transmembrane protein and soluble cytokine (sTNF). Both ligands interact with two different receptors, TNFR1 and TNFR2, which mediate their biological effects. TNF-α is involved in the p...

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Veröffentlicht in:	Journal of neuroimmunology 2011-05, Vol.234 (1), p.1-6
Hauptverfasser:	Caminero, Ana, Comabella, Manuel, Montalban, Xavier
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Anti-TNF-α Antibodies - therapeutic use Disease Models, Animal Humans Models, Biological Multiple sclerosis Multiple Sclerosis - therapy Neurology Proinflammatory cytokines Receptors, Tumor Necrosis Factor, Type I - metabolism Receptors, Tumor Necrosis Factor, Type II - metabolism TNF-α Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism
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