Polymorphisms in the ALOX12 gene and osteoporosis

Summary ALOX12 produces ligands for PPARγ thereby turning mesenchymal stem cells into adipocytes instead of osteoblasts. We investigated the effect of polymorphisms in the ALOX12 gene on BMD and fracture risk in two Danish cohorts and found four polymorphisms and a haplotype thereof to be associated...

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Veröffentlicht in:	Osteoporosis international 2011-08, Vol.22 (8), p.2249-2259
Hauptverfasser:	Harsløf, T., Husted, L. B., Nyegaard, M., Carstens, M., Stenkjær, L., Brixen, K., Eiken, P., Jensen, J-E. B., Børglum, A. D., Mosekilde, L., Rejnmark, L., Langdahl, B. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adult Aged Arachidonate 12-Lipoxygenase - genetics Biological and medical sciences Bone density Bone Density - genetics Bone loss Bone mineral density Diseases of the osteoarticular system Endocrinology Enzymes Epidemiologic Methods Estrogen Replacement Therapy Female Femur Fractures Gene Frequency Gene polymorphism Genetic Predisposition to Disease Genetics Genotype Genotyping Haplotypes Hip Hormones Humans Injuries of the limb. Injuries of the spine Linkage disequilibrium Male Medical sciences Medicine Medicine & Public Health Mesenchyme Middle Aged Original Article Orthopedics Osteoblasts Osteoporosis Osteoporosis - genetics Osteoporosis - physiopathology Osteoporosis, Postmenopausal - genetics Osteoporosis, Postmenopausal - physiopathology Osteoporosis, Postmenopausal - prevention & control Osteoporosis. Osteomalacia. Paget disease Osteoporotic Fractures - genetics Osteoporotic Fractures - physiopathology Osteoporotic Fractures - prevention & control Peroxisome proliferator-activated receptors Polymorphism, Single Nucleotide Rheumatology Risk assessment Risk factors Single-nucleotide polymorphism Spinal Fractures - genetics Spinal Fractures - physiopathology Spine (lumbar) Stem cells Traumas. Diseases due to physical agents Vertebrae
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