Injectable chitosan-based hydrogel for implantable drug delivery: Body response and induced variations of structure and composition
Thermosensitive hydrogel composed of chitosan and glycerophosphate (CS/GP) is proposed to be the potential candidate of in situ gel‐forming implant for long‐term drug delivery. The present study was focused on the body response and induced structural and componential variations of the hydrogel, whic...
Gespeichert in:
| Veröffentlicht in: | Journal of biomedical materials research. Part A 2010-12, Vol.95A (4), p.1019-1027 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1027 |
|---|---|
| container_issue | 4 |
| container_start_page | 1019 |
| container_title | Journal of biomedical materials research. Part A |
| container_volume | 95A |
| creator | Sun, Jiali Jiang, Guoqiang Qiu, Tingting Wang, Yujie Zhang, Kuo Ding, Fuxin |
| description | Thermosensitive hydrogel composed of chitosan and glycerophosphate (CS/GP) is proposed to be the potential candidate of in situ gel‐forming implant for long‐term drug delivery. The present study was focused on the body response and induced structural and componential variations of the hydrogel, which were considered to impact on the drug delivery significantly but were scarcely reported. The body response was investigated by histological examination. It showed that the hydrogel caused an inflammatory response immediately after being implanted into Sprague‐Dawley (SD) rats. The inflammatory response was mainly exhibited as inflammatory cell surrounding and infiltrating, tissue encapsulating, and vascularization in tissue. The effects of the inflammatory response on the structure and component of the CS/GP hydrogel were extensively explored through analyzing the hydorgel samples taken by surgery. The tissue encapsulation and osmotic pressure caused the water loss of the hydrogel and the compaction of the hydrogel network, and resulted in the porosity decreasing. The cell surrounding and infiltrating spawned big pores in the network and generated the subdivision of the network. All these structural and componential variations of the hydrogel in vivo were quite different from those in vitro and were supposed to exert significantly effects on drug release kinetics. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010. |
| doi_str_mv | 10.1002/jbm.a.32923 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_883025356</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>869590019</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4623-25f36c2c13eb07932c10b61f6eea86fe44fc5de928adc66206557485734f4cec3</originalsourceid><addsrcrecordid>eNqF0Utv1DAQAOAIgWgpnLgjXxAHlMWP2E640UJLUQuIhzhajj1uvSTxYieFnPnjeMm23OjB8sjzzYysKYrHBK8IxvTFuu1XesVoQ9mdYp9wTsuqEfzuNq6aMifEXvEgpXXGAnN6v9ijuJZUcrJf_D4d1mBG3XaAzKUfQ9JD2eoEFl3ONoYL6JALEfl-0-lhcTZOF8hC568gzi_RYbAzipA2YUiA9GCRH-xkcocrHb0efX5HwaE0xsmMU1yMCf0mJL_NPizuOd0leLS7D4qvx2--HL0tzz6cnB69OitNJSgrKXdMGGoIgxbLhuUIt4I4AaBr4aCqnOEWGlpra4SgWHAuq5pLVrnKgGEHxbOl7yaGHxOkUfU-GejyxyBMSdU1w5QzLm6XouENxqS5VUrBiOQS0yyfL9LEkFIEpzbR9zrOimC1XaTKi1Ra_V1k1k92fae2B3tjrzeXwdMd0MnozkU9GJ_-OVZVdT7ZkcX99B3M_5up3h2eXw8vlxqfRvh1U6PjdyUkk1x9e3-ixPHr-lPz-aM6Z38AjZXGmw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>763175702</pqid></control><display><type>article</type><title>Injectable chitosan-based hydrogel for implantable drug delivery: Body response and induced variations of structure and composition</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Sun, Jiali ; Jiang, Guoqiang ; Qiu, Tingting ; Wang, Yujie ; Zhang, Kuo ; Ding, Fuxin</creator><creatorcontrib>Sun, Jiali ; Jiang, Guoqiang ; Qiu, Tingting ; Wang, Yujie ; Zhang, Kuo ; Ding, Fuxin</creatorcontrib><description>Thermosensitive hydrogel composed of chitosan and glycerophosphate (CS/GP) is proposed to be the potential candidate of in situ gel‐forming implant for long‐term drug delivery. The present study was focused on the body response and induced structural and componential variations of the hydrogel, which were considered to impact on the drug delivery significantly but were scarcely reported. The body response was investigated by histological examination. It showed that the hydrogel caused an inflammatory response immediately after being implanted into Sprague‐Dawley (SD) rats. The inflammatory response was mainly exhibited as inflammatory cell surrounding and infiltrating, tissue encapsulating, and vascularization in tissue. The effects of the inflammatory response on the structure and component of the CS/GP hydrogel were extensively explored through analyzing the hydorgel samples taken by surgery. The tissue encapsulation and osmotic pressure caused the water loss of the hydrogel and the compaction of the hydrogel network, and resulted in the porosity decreasing. The cell surrounding and infiltrating spawned big pores in the network and generated the subdivision of the network. All these structural and componential variations of the hydrogel in vivo were quite different from those in vitro and were supposed to exert significantly effects on drug release kinetics. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.</description><identifier>ISSN: 1549-3296</identifier><identifier>ISSN: 1552-4965</identifier><identifier>EISSN: 1552-4965</identifier><identifier>DOI: 10.1002/jbm.a.32923</identifier><identifier>PMID: 20872751</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biological and medical sciences ; body response ; Calorimetry, Differential Scanning ; Chitosan - administration & dosage ; Chitosan - pharmacology ; chitosan/glycerophosphate hydrogel ; drug delivery ; Drug Delivery Systems - methods ; Freeze Drying ; Glycerophosphates - pharmacology ; Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage ; Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry ; Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology ; Hydrogen-Ion Concentration - drug effects ; Implants, Experimental ; injectable implant ; Injections ; Medical sciences ; Microscopy, Electron, Scanning ; Porosity - drug effects ; Prosthesis Implantation ; Rats ; Rats, Sprague-Dawley ; structural and componential variation ; Structure-Activity Relationship ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments ; Time Factors ; Viscosity - drug effects ; Water</subject><ispartof>Journal of biomedical materials research. Part A, 2010-12, Vol.95A (4), p.1019-1027</ispartof><rights>Copyright © 2010 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4623-25f36c2c13eb07932c10b61f6eea86fe44fc5de928adc66206557485734f4cec3</citedby><cites>FETCH-LOGICAL-c4623-25f36c2c13eb07932c10b61f6eea86fe44fc5de928adc66206557485734f4cec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbm.a.32923$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbm.a.32923$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23448344$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20872751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Jiali</creatorcontrib><creatorcontrib>Jiang, Guoqiang</creatorcontrib><creatorcontrib>Qiu, Tingting</creatorcontrib><creatorcontrib>Wang, Yujie</creatorcontrib><creatorcontrib>Zhang, Kuo</creatorcontrib><creatorcontrib>Ding, Fuxin</creatorcontrib><title>Injectable chitosan-based hydrogel for implantable drug delivery: Body response and induced variations of structure and composition</title><title>Journal of biomedical materials research. Part A</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Thermosensitive hydrogel composed of chitosan and glycerophosphate (CS/GP) is proposed to be the potential candidate of in situ gel‐forming implant for long‐term drug delivery. The present study was focused on the body response and induced structural and componential variations of the hydrogel, which were considered to impact on the drug delivery significantly but were scarcely reported. The body response was investigated by histological examination. It showed that the hydrogel caused an inflammatory response immediately after being implanted into Sprague‐Dawley (SD) rats. The inflammatory response was mainly exhibited as inflammatory cell surrounding and infiltrating, tissue encapsulating, and vascularization in tissue. The effects of the inflammatory response on the structure and component of the CS/GP hydrogel were extensively explored through analyzing the hydorgel samples taken by surgery. The tissue encapsulation and osmotic pressure caused the water loss of the hydrogel and the compaction of the hydrogel network, and resulted in the porosity decreasing. The cell surrounding and infiltrating spawned big pores in the network and generated the subdivision of the network. All these structural and componential variations of the hydrogel in vivo were quite different from those in vitro and were supposed to exert significantly effects on drug release kinetics. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>body response</subject><subject>Calorimetry, Differential Scanning</subject><subject>Chitosan - administration & dosage</subject><subject>Chitosan - pharmacology</subject><subject>chitosan/glycerophosphate hydrogel</subject><subject>drug delivery</subject><subject>Drug Delivery Systems - methods</subject><subject>Freeze Drying</subject><subject>Glycerophosphates - pharmacology</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology</subject><subject>Hydrogen-Ion Concentration - drug effects</subject><subject>Implants, Experimental</subject><subject>injectable implant</subject><subject>Injections</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Porosity - drug effects</subject><subject>Prosthesis Implantation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>structural and componential variation</subject><subject>Structure-Activity Relationship</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. Equipments</subject><subject>Time Factors</subject><subject>Viscosity - drug effects</subject><subject>Water</subject><issn>1549-3296</issn><issn>1552-4965</issn><issn>1552-4965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0Utv1DAQAOAIgWgpnLgjXxAHlMWP2E640UJLUQuIhzhajj1uvSTxYieFnPnjeMm23OjB8sjzzYysKYrHBK8IxvTFuu1XesVoQ9mdYp9wTsuqEfzuNq6aMifEXvEgpXXGAnN6v9ijuJZUcrJf_D4d1mBG3XaAzKUfQ9JD2eoEFl3ONoYL6JALEfl-0-lhcTZOF8hC568gzi_RYbAzipA2YUiA9GCRH-xkcocrHb0efX5HwaE0xsmMU1yMCf0mJL_NPizuOd0leLS7D4qvx2--HL0tzz6cnB69OitNJSgrKXdMGGoIgxbLhuUIt4I4AaBr4aCqnOEWGlpra4SgWHAuq5pLVrnKgGEHxbOl7yaGHxOkUfU-GejyxyBMSdU1w5QzLm6XouENxqS5VUrBiOQS0yyfL9LEkFIEpzbR9zrOimC1XaTKi1Ra_V1k1k92fae2B3tjrzeXwdMd0MnozkU9GJ_-OVZVdT7ZkcX99B3M_5up3h2eXw8vlxqfRvh1U6PjdyUkk1x9e3-ixPHr-lPz-aM6Z38AjZXGmw</recordid><startdate>20101215</startdate><enddate>20101215</enddate><creator>Sun, Jiali</creator><creator>Jiang, Guoqiang</creator><creator>Qiu, Tingting</creator><creator>Wang, Yujie</creator><creator>Zhang, Kuo</creator><creator>Ding, Fuxin</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20101215</creationdate><title>Injectable chitosan-based hydrogel for implantable drug delivery: Body response and induced variations of structure and composition</title><author>Sun, Jiali ; Jiang, Guoqiang ; Qiu, Tingting ; Wang, Yujie ; Zhang, Kuo ; Ding, Fuxin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4623-25f36c2c13eb07932c10b61f6eea86fe44fc5de928adc66206557485734f4cec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>body response</topic><topic>Calorimetry, Differential Scanning</topic><topic>Chitosan - administration & dosage</topic><topic>Chitosan - pharmacology</topic><topic>chitosan/glycerophosphate hydrogel</topic><topic>drug delivery</topic><topic>Drug Delivery Systems - methods</topic><topic>Freeze Drying</topic><topic>Glycerophosphates - pharmacology</topic><topic>Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage</topic><topic>Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry</topic><topic>Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology</topic><topic>Hydrogen-Ion Concentration - drug effects</topic><topic>Implants, Experimental</topic><topic>injectable implant</topic><topic>Injections</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Porosity - drug effects</topic><topic>Prosthesis Implantation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>structural and componential variation</topic><topic>Structure-Activity Relationship</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology. Biomaterials. Equipments</topic><topic>Time Factors</topic><topic>Viscosity - drug effects</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Jiali</creatorcontrib><creatorcontrib>Jiang, Guoqiang</creatorcontrib><creatorcontrib>Qiu, Tingting</creatorcontrib><creatorcontrib>Wang, Yujie</creatorcontrib><creatorcontrib>Zhang, Kuo</creatorcontrib><creatorcontrib>Ding, Fuxin</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of biomedical materials research. Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Jiali</au><au>Jiang, Guoqiang</au><au>Qiu, Tingting</au><au>Wang, Yujie</au><au>Zhang, Kuo</au><au>Ding, Fuxin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Injectable chitosan-based hydrogel for implantable drug delivery: Body response and induced variations of structure and composition</atitle><jtitle>Journal of biomedical materials research. Part A</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2010-12-15</date><risdate>2010</risdate><volume>95A</volume><issue>4</issue><spage>1019</spage><epage>1027</epage><pages>1019-1027</pages><issn>1549-3296</issn><issn>1552-4965</issn><eissn>1552-4965</eissn><abstract>Thermosensitive hydrogel composed of chitosan and glycerophosphate (CS/GP) is proposed to be the potential candidate of in situ gel‐forming implant for long‐term drug delivery. The present study was focused on the body response and induced structural and componential variations of the hydrogel, which were considered to impact on the drug delivery significantly but were scarcely reported. The body response was investigated by histological examination. It showed that the hydrogel caused an inflammatory response immediately after being implanted into Sprague‐Dawley (SD) rats. The inflammatory response was mainly exhibited as inflammatory cell surrounding and infiltrating, tissue encapsulating, and vascularization in tissue. The effects of the inflammatory response on the structure and component of the CS/GP hydrogel were extensively explored through analyzing the hydorgel samples taken by surgery. The tissue encapsulation and osmotic pressure caused the water loss of the hydrogel and the compaction of the hydrogel network, and resulted in the porosity decreasing. The cell surrounding and infiltrating spawned big pores in the network and generated the subdivision of the network. All these structural and componential variations of the hydrogel in vivo were quite different from those in vitro and were supposed to exert significantly effects on drug release kinetics. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20872751</pmid><doi>10.1002/jbm.a.32923</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1549-3296 |
| ispartof | Journal of biomedical materials research. Part A, 2010-12, Vol.95A (4), p.1019-1027 |
| issn | 1549-3296 1552-4965 1552-4965 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_883025356 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Animals Biological and medical sciences body response Calorimetry, Differential Scanning Chitosan - administration & dosage Chitosan - pharmacology chitosan/glycerophosphate hydrogel drug delivery Drug Delivery Systems - methods Freeze Drying Glycerophosphates - pharmacology Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology Hydrogen-Ion Concentration - drug effects Implants, Experimental injectable implant Injections Medical sciences Microscopy, Electron, Scanning Porosity - drug effects Prosthesis Implantation Rats Rats, Sprague-Dawley structural and componential variation Structure-Activity Relationship Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Time Factors Viscosity - drug effects Water |
| title | Injectable chitosan-based hydrogel for implantable drug delivery: Body response and induced variations of structure and composition |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T10%3A27%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Injectable%20chitosan-based%20hydrogel%20for%20implantable%20drug%20delivery:%20Body%20response%20and%20induced%20variations%20of%20structure%20and%20composition&rft.jtitle=Journal%20of%20biomedical%20materials%20research.%20Part%20A&rft.au=Sun,%20Jiali&rft.date=2010-12-15&rft.volume=95A&rft.issue=4&rft.spage=1019&rft.epage=1027&rft.pages=1019-1027&rft.issn=1549-3296&rft.eissn=1552-4965&rft_id=info:doi/10.1002/jbm.a.32923&rft_dat=%3Cproquest_cross%3E869590019%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=763175702&rft_id=info:pmid/20872751&rfr_iscdi=true |