In vivo performance of selective electron beam-melted Ti-6Al-4V structures
Highly porous titanium structures are widely used for maxillofacial and orthopedic surgery because of their excellent mechanical properties similar to those of human bone and their facilitation of bone ingrowth. In contrast to common methods, the generation of porous titaniumproducts by selective el...
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| Veröffentlicht in: | Journal of biomedical materials research. Part A 2010-01, Vol.92A (1), p.56-62 |
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| creator | Ponader, Sabine von Wilmowsky, Cornelius Widenmayer, Martin Lutz, Rainer Heinl, Peter Körner, Carolin Singer, Robert F. Nkenke, Emeka Neukam, Friedrich W. Schlegel, Karl A. |
| description | Highly porous titanium structures are widely used for maxillofacial and orthopedic surgery because of their excellent mechanical properties similar to those of human bone and their facilitation of bone ingrowth. In contrast to common methods, the generation of porous titaniumproducts by selective electron beam melting (SEBM), an additive manufacturing technology, overcomes difficulties concerning the extreme chemical affinity of liquid titanium to atmospheric gases which consequently leads to strongly reduced ductility of the metal. The purpose of this study was to assess the suitability of a smooth compact and a porous Ti‐6Al‐4V structure directly produced by the SEBM process as scaffolds for bone formation. SEBM‐processed titanium implants were placed into defects in the frontal skull of 15 domestic pigs. To evaluate the direct contact between bone and implant surfaces and to assess the ingrowth of osseous tissue into the porous structure, microradiographs and histomorphometric analyses were performed 14, 30, and 60 days after surgery. Bone ingrowth increased significantly during the period of this study. After 14 days the most outer regions of the implants were already filled with newly formed bone tissue (around 14%). After 30 days the bone volume inside the implants reached almost 30% and after 60 days abundant bone formation inside the implants attained 46%. During the study only scarce bone–implant contact was found around all implants, which did not exceed 9% around compact specimens and 6% around porous specimens after 60 days. This work demonstrates that highly porous titanium implants with excellent interconnectivity manufactured using the SEBM method are suitable scaffolds for bone ingrowth. This technique is a good candidate for orthopedic and maxillofacial applications. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010 |
| doi_str_mv | 10.1002/jbm.a.32337 |
| format | Article |
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In contrast to common methods, the generation of porous titaniumproducts by selective electron beam melting (SEBM), an additive manufacturing technology, overcomes difficulties concerning the extreme chemical affinity of liquid titanium to atmospheric gases which consequently leads to strongly reduced ductility of the metal. The purpose of this study was to assess the suitability of a smooth compact and a porous Ti‐6Al‐4V structure directly produced by the SEBM process as scaffolds for bone formation. SEBM‐processed titanium implants were placed into defects in the frontal skull of 15 domestic pigs. To evaluate the direct contact between bone and implant surfaces and to assess the ingrowth of osseous tissue into the porous structure, microradiographs and histomorphometric analyses were performed 14, 30, and 60 days after surgery. Bone ingrowth increased significantly during the period of this study. After 14 days the most outer regions of the implants were already filled with newly formed bone tissue (around 14%). After 30 days the bone volume inside the implants reached almost 30% and after 60 days abundant bone formation inside the implants attained 46%. During the study only scarce bone–implant contact was found around all implants, which did not exceed 9% around compact specimens and 6% around porous specimens after 60 days. This work demonstrates that highly porous titanium implants with excellent interconnectivity manufactured using the SEBM method are suitable scaffolds for bone ingrowth. This technique is a good candidate for orthopedic and maxillofacial applications. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010</description><identifier>ISSN: 1549-3296</identifier><identifier>ISSN: 1552-4965</identifier><identifier>EISSN: 1552-4965</identifier><identifier>DOI: 10.1002/jbm.a.32337</identifier><identifier>PMID: 19165781</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Atmospheric gases ; Biological and medical sciences ; Bone and Bones - drug effects ; Bone and Bones - pathology ; Bone growth ; Bone implants ; bone ingrowth ; bone regeneration ; Bone Regeneration - drug effects ; Bone surgery ; Domestic animals ; Ductility ; Ductility tests ; Electron beam melting ; Electrons ; Materials Testing - methods ; Maxillofacial ; Mechanical properties ; Medical sciences ; Microscopy, Electron, Scanning ; Organ Size - drug effects ; Orthopedic surgery ; Orthopedics ; Osteogenesis ; Osteogenesis - drug effects ; Porosity - drug effects ; porous structures ; Prostheses and Implants ; Scaffolds ; selective electron beam melting (SEBM) ; Staining and Labeling ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgical implants ; Sus scrofa ; Titanium ; Titanium - pharmacology ; titanium alloys ; Titanium base alloys ; Tolonium Chloride - metabolism ; Transplants & implants</subject><ispartof>Journal of biomedical materials research. Part A, 2010-01, Vol.92A (1), p.56-62</ispartof><rights>Copyright © 2009 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Wiley Subscription Services, Inc. Jan 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5567-8a6201ce7d127efd019789fb51b8a72635f8d8c0f7c764467208d5db2d07ef203</citedby><cites>FETCH-LOGICAL-c5567-8a6201ce7d127efd019789fb51b8a72635f8d8c0f7c764467208d5db2d07ef203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbm.a.32337$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbm.a.32337$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22405426$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19165781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ponader, Sabine</creatorcontrib><creatorcontrib>von Wilmowsky, Cornelius</creatorcontrib><creatorcontrib>Widenmayer, Martin</creatorcontrib><creatorcontrib>Lutz, Rainer</creatorcontrib><creatorcontrib>Heinl, Peter</creatorcontrib><creatorcontrib>Körner, Carolin</creatorcontrib><creatorcontrib>Singer, Robert F.</creatorcontrib><creatorcontrib>Nkenke, Emeka</creatorcontrib><creatorcontrib>Neukam, Friedrich W.</creatorcontrib><creatorcontrib>Schlegel, Karl A.</creatorcontrib><title>In vivo performance of selective electron beam-melted Ti-6Al-4V structures</title><title>Journal of biomedical materials research. Part A</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Highly porous titanium structures are widely used for maxillofacial and orthopedic surgery because of their excellent mechanical properties similar to those of human bone and their facilitation of bone ingrowth. In contrast to common methods, the generation of porous titaniumproducts by selective electron beam melting (SEBM), an additive manufacturing technology, overcomes difficulties concerning the extreme chemical affinity of liquid titanium to atmospheric gases which consequently leads to strongly reduced ductility of the metal. The purpose of this study was to assess the suitability of a smooth compact and a porous Ti‐6Al‐4V structure directly produced by the SEBM process as scaffolds for bone formation. SEBM‐processed titanium implants were placed into defects in the frontal skull of 15 domestic pigs. To evaluate the direct contact between bone and implant surfaces and to assess the ingrowth of osseous tissue into the porous structure, microradiographs and histomorphometric analyses were performed 14, 30, and 60 days after surgery. Bone ingrowth increased significantly during the period of this study. After 14 days the most outer regions of the implants were already filled with newly formed bone tissue (around 14%). After 30 days the bone volume inside the implants reached almost 30% and after 60 days abundant bone formation inside the implants attained 46%. During the study only scarce bone–implant contact was found around all implants, which did not exceed 9% around compact specimens and 6% around porous specimens after 60 days. This work demonstrates that highly porous titanium implants with excellent interconnectivity manufactured using the SEBM method are suitable scaffolds for bone ingrowth. This technique is a good candidate for orthopedic and maxillofacial applications. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010</description><subject>Animals</subject><subject>Atmospheric gases</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - pathology</subject><subject>Bone growth</subject><subject>Bone implants</subject><subject>bone ingrowth</subject><subject>bone regeneration</subject><subject>Bone Regeneration - drug effects</subject><subject>Bone surgery</subject><subject>Domestic animals</subject><subject>Ductility</subject><subject>Ductility tests</subject><subject>Electron beam melting</subject><subject>Electrons</subject><subject>Materials Testing - methods</subject><subject>Maxillofacial</subject><subject>Mechanical properties</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Organ Size - drug effects</subject><subject>Orthopedic surgery</subject><subject>Orthopedics</subject><subject>Osteogenesis</subject><subject>Osteogenesis - drug effects</subject><subject>Porosity - drug effects</subject><subject>porous structures</subject><subject>Prostheses and Implants</subject><subject>Scaffolds</subject><subject>selective electron beam melting (SEBM)</subject><subject>Staining and Labeling</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgical implants</subject><subject>Sus scrofa</subject><subject>Titanium</subject><subject>Titanium - pharmacology</subject><subject>titanium alloys</subject><subject>Titanium base alloys</subject><subject>Tolonium Chloride - metabolism</subject><subject>Transplants & implants</subject><issn>1549-3296</issn><issn>1552-4965</issn><issn>1552-4965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0btvFDEQB2ALgUhyUNGjlVCUItrD70cZErgkClBwBDrL6x1Le-zjsHcP8t_HyR1BoiCVp_hmRuMfQq8InhOM6dtV1c3dnFHG1BO0T4SgJTdSPL2ruSkZNXIPHaS0ylhiQZ-jPWKIFEqTfXR50RebZjMUa4hhiJ3rPRRDKBK04MdmA8V9EYe-qMB1ZQftCHWxbEp50pb8ukhjnPw4RUgv0LPg2gQvd-8Mff3wfnl6Xl59XlycnlyVXgipSu0kxcSDqglVEGpMjNImVIJU2ikqmQi61h4H5ZXkXCqKdS3qitY4c4rZDB1t567j8HOCNNquSR7a1vUwTMlqzTDlhIvHpTRCSW3Mo1IxTgTVSmf55h-5GqbY54MtNUwJojlTWR1vlY9DShGCXcemc_HGEmzvUrM5NevsfWpZv97NnKoO6r92F1MGhzvgkndtiDmmJj04SjkWPH_dDJGt-9W0cPO_nfby3cc_y8ttT5NG-P3Q4-IPK1U-yH77tLDm7PvinH5Z2mt2C0aXu1c</recordid><startdate>201001</startdate><enddate>201001</enddate><creator>Ponader, Sabine</creator><creator>von Wilmowsky, Cornelius</creator><creator>Widenmayer, Martin</creator><creator>Lutz, Rainer</creator><creator>Heinl, Peter</creator><creator>Körner, Carolin</creator><creator>Singer, Robert F.</creator><creator>Nkenke, Emeka</creator><creator>Neukam, Friedrich W.</creator><creator>Schlegel, Karl A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>201001</creationdate><title>In vivo performance of selective electron beam-melted Ti-6Al-4V structures</title><author>Ponader, Sabine ; von Wilmowsky, Cornelius ; Widenmayer, Martin ; Lutz, Rainer ; Heinl, Peter ; Körner, Carolin ; Singer, Robert F. ; Nkenke, Emeka ; Neukam, Friedrich W. ; Schlegel, Karl A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5567-8a6201ce7d127efd019789fb51b8a72635f8d8c0f7c764467208d5db2d07ef203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Atmospheric gases</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - drug effects</topic><topic>Bone and Bones - pathology</topic><topic>Bone growth</topic><topic>Bone implants</topic><topic>bone ingrowth</topic><topic>bone regeneration</topic><topic>Bone Regeneration - drug effects</topic><topic>Bone surgery</topic><topic>Domestic animals</topic><topic>Ductility</topic><topic>Ductility tests</topic><topic>Electron beam melting</topic><topic>Electrons</topic><topic>Materials Testing - methods</topic><topic>Maxillofacial</topic><topic>Mechanical properties</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Organ Size - drug effects</topic><topic>Orthopedic surgery</topic><topic>Orthopedics</topic><topic>Osteogenesis</topic><topic>Osteogenesis - drug effects</topic><topic>Porosity - drug effects</topic><topic>porous structures</topic><topic>Prostheses and Implants</topic><topic>Scaffolds</topic><topic>selective electron beam melting (SEBM)</topic><topic>Staining and Labeling</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. 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Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ponader, Sabine</au><au>von Wilmowsky, Cornelius</au><au>Widenmayer, Martin</au><au>Lutz, Rainer</au><au>Heinl, Peter</au><au>Körner, Carolin</au><au>Singer, Robert F.</au><au>Nkenke, Emeka</au><au>Neukam, Friedrich W.</au><au>Schlegel, Karl A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo performance of selective electron beam-melted Ti-6Al-4V structures</atitle><jtitle>Journal of biomedical materials research. Part A</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2010-01</date><risdate>2010</risdate><volume>92A</volume><issue>1</issue><spage>56</spage><epage>62</epage><pages>56-62</pages><issn>1549-3296</issn><issn>1552-4965</issn><eissn>1552-4965</eissn><abstract>Highly porous titanium structures are widely used for maxillofacial and orthopedic surgery because of their excellent mechanical properties similar to those of human bone and their facilitation of bone ingrowth. In contrast to common methods, the generation of porous titaniumproducts by selective electron beam melting (SEBM), an additive manufacturing technology, overcomes difficulties concerning the extreme chemical affinity of liquid titanium to atmospheric gases which consequently leads to strongly reduced ductility of the metal. The purpose of this study was to assess the suitability of a smooth compact and a porous Ti‐6Al‐4V structure directly produced by the SEBM process as scaffolds for bone formation. SEBM‐processed titanium implants were placed into defects in the frontal skull of 15 domestic pigs. To evaluate the direct contact between bone and implant surfaces and to assess the ingrowth of osseous tissue into the porous structure, microradiographs and histomorphometric analyses were performed 14, 30, and 60 days after surgery. Bone ingrowth increased significantly during the period of this study. After 14 days the most outer regions of the implants were already filled with newly formed bone tissue (around 14%). After 30 days the bone volume inside the implants reached almost 30% and after 60 days abundant bone formation inside the implants attained 46%. During the study only scarce bone–implant contact was found around all implants, which did not exceed 9% around compact specimens and 6% around porous specimens after 60 days. This work demonstrates that highly porous titanium implants with excellent interconnectivity manufactured using the SEBM method are suitable scaffolds for bone ingrowth. This technique is a good candidate for orthopedic and maxillofacial applications. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19165781</pmid><doi>10.1002/jbm.a.32337</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Atmospheric gases Biological and medical sciences Bone and Bones - drug effects Bone and Bones - pathology Bone growth Bone implants bone ingrowth bone regeneration Bone Regeneration - drug effects Bone surgery Domestic animals Ductility Ductility tests Electron beam melting Electrons Materials Testing - methods Maxillofacial Mechanical properties Medical sciences Microscopy, Electron, Scanning Organ Size - drug effects Orthopedic surgery Orthopedics Osteogenesis Osteogenesis - drug effects Porosity - drug effects porous structures Prostheses and Implants Scaffolds selective electron beam melting (SEBM) Staining and Labeling Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical implants Sus scrofa Titanium Titanium - pharmacology titanium alloys Titanium base alloys Tolonium Chloride - metabolism Transplants & implants |
| title | In vivo performance of selective electron beam-melted Ti-6Al-4V structures |
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