Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1

Of the three major types of ionotropic glutamate receptors, synaptic kainite receptors have slow channel kinetics. This study characterizes Neto1, a novel auxiliary subunit of kainite receptor that directly modulates ligand binding and slow kinetics of kainite receptors. Ionotropic glutamate recepto...

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Veröffentlicht in:	Nature neuroscience 2011-07, Vol.14 (7), p.866-873
Hauptverfasser:	Castillo, Pablo E, Tomita, Susumu, Straub, Christoph, Hunt, David L, Yamasaki, Miwako, Kim, Kwang S, Watanabe, Masahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1595/1554 631/378/340 631/378/548/1964 631/443/376 Animal Genetics and Genomics Animals Animals, Newborn Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Biophysical Phenomena - drug effects Biophysical Phenomena - genetics Biophysics Brain CA1 Region, Hippocampal - cytology CA1 Region, Hippocampal - metabolism Cell Line, Transformed Cell receptors Cerebellum - cytology Cerebellum - metabolism Disks Large Homolog 4 Protein Dizocilpine Maleate - pharmacology Dose-Response Relationship, Drug Drug Interactions Electric Stimulation - methods Excitatory Amino Acid Agonists - pharmacokinetics Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - genetics Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Green Fluorescent Proteins - genetics Guanylate Kinases Humans Immunoprecipitation In Vitro Techniques Intracellular Signaling Peptides and Proteins - metabolism Kainic Acid - pharmacokinetics Kainic Acid - pharmacology LDL-Receptor Related Proteins Lipoproteins, LDL - deficiency Lipoproteins, LDL - metabolism Membrane Potentials - drug effects Membrane Potentials - genetics Membrane Proteins - deficiency Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout Neural transmission Neurobiology Neurons - classification Neurons - drug effects Neurons - physiology Neurosciences Patch-Clamp Techniques - methods Physiological aspects Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Protein Binding - drug effects Protein Subunits - genetics Protein Subunits - metabolism Receptors, Kainic Acid - classification Receptors, Kainic Acid - deficiency Receptors, Kainic Acid - physiology Synaptophysin - metabolism Transfection - methods Tritium - pharmacokinetics
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