TLR9-dependent systemic interferon-β production by intravenous injection of plasmid DNA/cationic liposome complex in mice

Background The type I interferon (IFN) response to DNA/cationic liposome complex, or lipoplex, has been reported in cultured cells, but little is known about the response in vivo. Studies of the pro‐inflammatory cytokine response to lipoplex have shown the importance of the unmethylated CpG dinucleo...

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Veröffentlicht in:	The journal of gene medicine 2009-08, Vol.11 (8), p.708-717
Hauptverfasser:	Yoshida, Hiroyuki, Nishikawa, Makiya, Yasuda, Sachiyo, Mizuno, Yumiko, Toyota, Hiroyasu, Kiyota, Tsuyoshi, Takahashi, Rei, Takakura, Yoshinobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cations Cell Separation Clodronic Acid - pharmacology CpG Islands - genetics CpG motif DNA - administration & dosage Injections, Intravenous Interferon-beta - biosynthesis Interferon-beta - blood interferon-β Interleukin-6 - biosynthesis Interleukin-6 - blood Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects lipoplex Liposomes Lung - blood supply Lung - cytology Lung - drug effects Mice Mice, Inbred ICR plasmid DNA Plasmids - administration & dosage Splenectomy Toll-Like Receptor 9 - metabolism Toll-like receptor-9
Online-Zugang:	Volltext
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