The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene

The Salvador-Warts-Hippo (SWH) pathway was first discovered in Drosophila melanogaster as a potent inhibitor of tissue growth. The SWH pathway is highly conserved between D . melanogaster and mammals, both in function and in the mechanism of signal transduction. The mammalian SWH pathway limits tiss...

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Veröffentlicht in:	Oncogene 2011-06, Vol.30 (25), p.2810-2822
Hauptverfasser:	Zhang, X, George, J, Deb, S, Degoutin, J L, Takano, E A, Fox, S B, Bowtell, D D L, Harvey, K F
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/395 631/80/83/2360 692/420/755 692/699/67/1517/1709 Antineoplastic Agents - pharmacology Apoptosis Biological and medical sciences Cell Biology Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chemotherapy Cisplatin - pharmacology Derepression DNA microarrays Drosophila melanogaster Female Female genital diseases Fundamental and applied biological sciences. Psychology Gene expression Genetic aspects Gynecology. Andrology. Obstetrics Human Genetics Humans Insects Internal Medicine Invasiveness Mammals Medical prognosis Medical sciences Medicine Medicine & Public Health Molecular and cellular biology Nuclear Proteins - genetics Nuclear Proteins - physiology Oncogenes Oncology original-article Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Paclitaxel - pharmacology Phenotypes Signal transduction Therapeutic targets Trans-Activators - genetics Trans-Activators - physiology Transcription Transcription Factors - genetics Transcription Factors - physiology Transcriptional coactivators Tumor cell lines Tumorigenesis Tumors Warts Yes-associated protein
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