G glycoprotein amino acid residues required for human monoclonal antibody RAB1 neutralization are conserved in rabies virus street isolates

Replacement of polyclonal anti-rabies immunoglobulin (RIG) used in rabies post-exposure prophylaxis (PEP) with a monoclonal antibody will eliminate cost and availability constraints that currently exist using RIG in the developing world. The human monoclonal antibody RAB1 has been shown to neutraliz...

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Veröffentlicht in:	Antiviral research 2011-08, Vol.91 (2), p.187-194
Hauptverfasser:	Wang, Yang, Rowley, Kirk J., Booth, Brian J., Sloan, Susan E., Ambrosino, Donna M., Babcock, Gregory J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Antibiotics. Antiinfectious agents. Antiparasitic agents Antibodies, Monoclonal - immunology Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Antigens, Viral - genetics Antigens, Viral - immunology Antigens, Viral - metabolism Antiviral agents Asparagine - metabolism Binding Sites, Antibody Biological and medical sciences Cloning, Molecular Fundamental and applied biological sciences. Psychology G glycoprotein Glycoproteins - genetics Glycoproteins - immunology Glycoproteins - metabolism HEK293 Cells Humans Lentivirus Medical sciences Microbiology Monoclonal antibody Mutagenesis, Site-Directed - methods Neutralization Neutralization Tests Pharmacology. Drug treatments Point Mutation Pseudovirus Rabies virus Rabies virus - genetics Rabies virus - immunology Rabies virus - metabolism Sequence Analysis, Protein Transfection Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Viral Envelope Proteins - metabolism Virology
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