Mannose binding lectin gene (MBL2) functional polymorphisms are associated with systemic lupus erythematosus in southern Brazilians

Abstract Susceptibility to systemic lupus erythematosus (SLE) has been associated with immunologic, environmental, and genetic factors. To uncover a possible association between MBL2 gene polymorphisms and SLE, we analyzed functional polymorphisms in the promoter and first exon of the MBL2 gene in 1...

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Veröffentlicht in:	Human immunology 2011-06, Vol.72 (6), p.516-521
Hauptverfasser:	Sandrin-Garcia, Paula, Brandão, Lucas André Cavalcanti, Coelho, Antônio Victor Campos, Guimarães, Rafael Lima, Pancoto, João Alexandre Trés, Segat, Ludovica, Donadi, Eduardo Antônio, de Lima-Filho, José Luiz, Crovella, Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Allergy and Immunology Antiphospholipid syndrome Brazil Data processing DNA Mutational Analysis Exons Female Gene Frequency Gene polymorphism Genetic Association Studies Genetic factors Genetic Predisposition to Disease Genotype Humans Lectins Lupus Erythematosus, Systemic - epidemiology Lupus Erythematosus, Systemic - genetics Male Mannose Mannose binding lectin Mannose-Binding Lectin - genetics MBL2 gene polymorphisms Middle Aged Nephritic disorders Nephritis Polymorphism, Genetic Population Groups Promoter Regions, Genetic - genetics Promoters Risk factors Systemic lupus erythematosus
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