Cilostazol enhances neovascularization in the mouse hippocampus after transient forebrain ischemia

Cilostazol is known to be a specific type III phosphodiesterase inhibitor, which promotes increased intracellular cAMP levels. We assessed the effect of cilostazol on production of angioneurins and chemokines and recruitment of new endothelial cells for vasculogenesis in a mouse model of transient f...

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Veröffentlicht in:	Journal of neuroscience research 2010-08, Vol.88 (10), p.2228-2238
Hauptverfasser:	Shin, Hwa Kyoung, Lee, Hye Rin, Lee, Dong Hyung, Hong, Ki Whan, Lee, Jeong Hyun, Park, So Youn, Lee, Seung Jin, Lee, Jun Sik, Lee, Won Suk, Rhim, Byung Yong, Kim, Chi Dae
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Stem Cells - drug effects Adult Stem Cells - physiology Animals CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - pathology CA1 Region, Hippocampal - physiopathology CD31 Cell Death - drug effects Cell Proliferation - drug effects cilostazol Disease Models, Animal Endothelial Cells - drug effects Endothelial Cells - physiology endothelial progenitor cells Hippocampus - drug effects Hippocampus - pathology Hippocampus - physiopathology Ischemic Attack, Transient - drug therapy Ischemic Attack, Transient - pathology Ischemic Attack, Transient - physiopathology Male Mice Mice, Inbred C57BL Neovascularization, Physiologic - drug effects Phosphodiesterase Inhibitors - pharmacology Prosencephalon - drug effects Prosencephalon - pathology Prosencephalon - physiopathology Tetrazoles - pharmacology transient forebrain ischemia vasculogenesis
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