Investigation of annexin A5 as a biomarker for Alzheimer's disease using neuronal cell culture and mouse model

Alzheimer's disease (AD) differs from other forms of dementia in its relation to amyloid β peptide (Aβ). Aβ, a proteolytic product of amyloid precursor proteins (APP), has a toxic effect on neuronal cells, which involves perturbation of their Ca2+ homeostasis. This effect implies that changes o...

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Veröffentlicht in:	Journal of neuroscience research 2010-09, Vol.88 (12), p.2682-2692
Hauptverfasser:	Yamaguchi, Mami, Kokai, Yasuo, Imai, Shin-Ichi, Utsumi, Kumiko, Matsumoto, Kyoichi, Honda, Hirohito, Mizue, Yuka, Momma, Masako, Maeda, Tetsu, Toyomasu, Shozo, Ito, Yoichi M., Kobayashi, Seijyu, Hashimoto, Eri, Saito, Toshikazu, Sohma, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - blood Alzheimer Disease - diagnosis Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Protein Precursor - biosynthesis Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - physiology Animals annexin A5 Annexin A5 - biosynthesis Annexin A5 - blood biomarker Biomarkers - blood Ca2+ stress Calcium Signaling - physiology Cell Culture Techniques - methods Cells, Cultured Cerebral Cortex - metabolism Cerebral Cortex - pathology Disease Models, Animal Female Gene Expression Regulation - physiology Homeostasis - genetics Homeostasis - physiology Humans Male Mice Mice, Inbred ICR Mice, Transgenic Neurons - cytology Neurons - metabolism Neurons - pathology Organ Specificity - genetics Organ Specificity - physiology
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