The Antiasthma Effect of Neonatal BCG Vaccination Does Not Depend on the Th17/Th1 but IL-17/IFN-γ Balance in a BALB/c Mouse Asthma Model

Objective This study aimed to determine whether the protective effects of the Mycobacterium bovis Bacillus Calmette–Guérin (BCG) vaccination on allergic asthma are associated with the T helper (Th) 17/Th1 balance in a murine asthma model. Methods BALB/c neonates were vaccinated with BCG on the first...

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Veröffentlicht in:	Journal of clinical immunology 2011-06, Vol.31 (3), p.419-429
Hauptverfasser:	Deng, Yu, Chen, Weichao, Zang, Na, Li, Siming, Luo, Yan, Ni, Ke, Wang, Lijia, Xie, Xiaohong, Liu, Wei, Yang, Xiqiang, Fu, Zhou, Liu, Enmei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Asthma - immunology Asthma - pathology Asthma - physiopathology Asthma - prevention & control BCG Vaccine - administration & dosage BCG Vaccine - immunology Biomedical and Life Sciences Biomedicine Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Disease Models, Animal Down-Regulation Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Immunology Infectious Diseases Interferon-gamma - biosynthesis Interleukin-17 - biosynthesis Internal Medicine Lung - immunology Lung - pathology Lung - physiopathology Medical Microbiology Mice Mice, Inbred BALB C Mycobacterium bovis Mycobacterium bovis - immunology Ovalbumin - administration & dosage Ovalbumin - immunology Th17 Cells - drug effects Th17 Cells - immunology Th17 Cells - metabolism Up-Regulation Vaccination
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