Use of the hydantoin isostere to produce inhibitors showing selectivity toward the vesicular glutamate transporter versus the obligate exchange transporter system

Evidence was acquired prior to suggest that the vesicular glutamate transporter (VGLUT) but not other glutamate transporters were inhibited by structures containing a weakly basic alpha -amino group. To test this hypothesis, a series of analogs using a hydantoin (pK sub(a [not, vert, similar] 9.1) i...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2011-07, Vol.21 (14), p.4358-4362
Hauptverfasser:	Ahmed, S. Kaleem, Etoga, Jean-Louis G., Patel, Sarjubhai A., Bridges, Richard J., Thompson, Charles M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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