Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice

Previous studies in rats have suggested a causal relationship between progressive pulmonary inflammation and lung fibrosis induced by crystalline silica particles. We report here that, in NMRI mice, the lung response to silica particles is accompanied by a mild and non progressive pulmonary inflamma...

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Veröffentlicht in:	Toxicology letters 2011-06, Vol.203 (2), p.127-134
Hauptverfasser:	Rabolli, Virginie, Lo Re, Sandra, Uwambayinema, Francine, Yakoub, Yousof, Lison, Dominique, Huaux, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory treatment Biological and medical sciences Bronchoalveolar Lavage Fluid Cell Count Collagen - metabolism Collagens Crystal structure Cyclooxygenase Inhibitors - pharmacology Cytokines Female Fibrosis Inflammatory cytokines Inhibitors Interleukin-10 - biosynthesis L-Lactate Dehydrogenase - metabolism Lung fibrosis Lung inflammation Lungs Medical sciences Mice Mice, Inbred C57BL Mice, Inbred DBA Phosphodiesterase 5 Inhibitors - pharmacology Piperazines - pharmacology Piroxicam - pharmacology Pneumology Pneumonia - chemically induced Pneumonia - drug therapy Pneumonia - immunology Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - drug therapy Pulmonary Fibrosis - immunology Purines - pharmacology Respiratory system : syndromes and miscellaneous diseases Sildenafil Citrate Silica Silicon dioxide Silicon Dioxide - toxicity Sulfones - pharmacology Suppressive cytokines Toxicology Transforming Growth Factor beta - biosynthesis
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