Ras/Erk pathway positively regulates Jak1/STAT6 activity and IL-4 gene expression in Jurkat T cells

T helper cells can be largely divided into two functional subsets, Th1 and Th2, which are characterized by the cytokines they produce. The mechanism of Th1 versus Th2 cytokine production is thought to involve interaction of TCR-induced signal and cytokine-induced signal, mainly activating the Ras/MA...

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Veröffentlicht in:	Molecular immunology 2007-07, Vol.44 (13), p.3416-3426
Hauptverfasser:	So, Eui-Young, Oh, Jiyoung, Jang, Ji-Young, Kim, Jeong-Ho, Lee, Choong-Eun
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Communication - genetics Cell Communication - immunology Cell Line Enzyme Activation - genetics Enzyme Activation - immunology Enzyme Induction - genetics Enzyme Induction - immunology Extracellular Signal-Regulated MAP Kinases - physiology Functional cross-talk Humans IL-4 Interleukin-4 - biosynthesis Interleukin-4 - genetics Interleukin-4 - physiology Jak1/Stat6 Janus Kinase 1 - metabolism Jurkat Cells MAP Kinase Signaling System - genetics MAP Kinase Signaling System - immunology Proto-Oncogene Proteins c-akt - metabolism ras Proteins - physiology Ras/Erk STAT6 Transcription Factor - metabolism STAT6 Transcription Factor - physiology T-Lymphocytes - enzymology T-Lymphocytes - metabolism Th cell differentiation Th2 Cells - cytology Th2 Cells - enzymology Up-Regulation - immunology
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