Endotoxin tolerance: Selective alterations in gene expression and protection against lymphocyte death

Abstract Extensive lymphocyte apoptosis may be an important cause of immune suppression in sepsis. Here we investigated the effect of LPS tolerance on lymphocyte apoptosis in an experimental model of polymicrobial infection. Tolerance was induced by the injection of lipopolysaccharide (1.0 mg/kg/sub...

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Veröffentlicht in:	Immunobiology (1979) 2010-06, Vol.215 (6), p.435-442
Hauptverfasser:	Melo, Edielle S, Goloubkova, Tatiana, Barbeiro, Denise F, Gorjão, Renata, Vasconcelos, Dewton, Szabo, Csaba, Curi, Rui, de Lima Salgado, Thais Martins, Velasco, Irineu T, Soriano, Francisco G
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Allergy and Immunology Animals Apoptosis Apoptosis - drug effects Apoptosis - immunology Caspase CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Survival - drug effects Cell Survival - immunology Cytokines Differentiation Endotoxins Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Helper cells Immune Tolerance - immunology Immunological tolerance Infection Inflammation Lipopolysaccharides Lipopolysaccharides - pharmacology Lymphocytes T Mice Mice, Inbred BALB C Mitochondria Necrosis Oligonucleotide Array Sequence Analysis RNA, Messenger - biosynthesis RNA, Messenger - immunology Sepsis Sepsis - immunology Sepsis - metabolism Sepsis - prevention & control Shock T-cells
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