Different pathways lead to mitochondrial fragmentation during apoptotic and excitotoxic cell death in primary neurons

Mitochondrial fragmentation is recognized to be an important event during the onset of apoptosis. In this current study, we have used single cell imaging to investigate the role of the mitochondrial fission protein DRP‐1 on mitochondrial morphology and mitochondrial fragmentation in primary hippocam...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2010-09, Vol.24 (5), p.335-341
Hauptverfasser:	Young, Kenneth W., Piñon, Lucia G. P., Bampton, Edward T. W., Nicotera, Pierluigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Apoptosis - physiology Bax Bax protein bcl-2-Associated X Protein - metabolism Biochemistry Calcium Calcium (mitochondrial) Calcium - metabolism Calcium influx Cell Death - physiology Cells, Cultured Condensation Cytology DRP-1 Excitotoxicity Glutamate Glutamic acid Glutamic Acid - pharmacology Hippocampus Hippocampus - cytology Hippocampus - metabolism Internet Membranes Mitochondria Mitochondria - drug effects Mitochondria - metabolism Morphology Mortality Necrosis Necrosis - metabolism Neurons Neurons - cytology Neurons - metabolism Neurotoxins - pharmacology Plasmids - genetics Proteins Rats recruitment Staurosporine Staurosporine - pharmacology Transfection
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