Synthesis of a novel human PPARδ selective agonist and its stimulatory effect on oligodendrocyte differentiation

We have succeeded in synthesizing a novel PPARδ selective agonist, compound 20, characterized by a benzisoxazole ring. Compound 20 exhibited a potent hPPARδ transactivation activity and high δ selectivity. Compound 20 stimulated oligodendrocyte differentiation of primary oligodendrocyte precursors c...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2011-01, Vol.21 (1), p.240-244
Hauptverfasser:	Sakuma, Shogo, Endo, Tsuyoshi, Kanda, Takashi, Nakamura, Hideki, Yamasaki, Satomi, Yamakawa, Tomio
Format:	Artikel
Sprache:	eng
Schlagworte:	agonists Animals Benzisoxazole ring Biological and medical sciences Brain - pathology Cell Differentiation Compound 20 drug therapy Humans Isoxazoles - chemical synthesis Isoxazoles - chemistry Isoxazoles - therapeutic use Medical sciences Miscellaneous Multiple sclerosis Multiple Sclerosis - drug therapy Neuropharmacology Oligodendrocyte Oligodendroglia - cytology Oxazoles - chemical synthesis Oxazoles - chemistry Oxazoles - therapeutic use Pharmacology. Drug treatments PPAR delta - agonists PPAR delta - metabolism PPARδ agonist Rats sclerosis Transcriptional Activation
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