Combining keratinocyte growth factor transfection into the airways and tracheal occlusion in a fetal sheep model of congenital diaphragmatic hernia

Background In utero tracheal occlusion (TO) has been developed to improve the lung hypoplasia associated with congenital diaphragmatic hernia (CDH). However, although TO stimulates fetal lung growth, it results in a decrease of alveolar type II cells (ATII) and surfactant production. Because keratin...

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Veröffentlicht in:	The journal of gene medicine 2010-05, Vol.12 (5), p.413-422
Hauptverfasser:	Saada, Julien, Oudrhiri, Noufissa, Bonnard, Arnaud, de Lagausie, Pascal, Aissaoui, Abderrahim, Hauchecorne, Michelle, Oury, Jean-François, Aigrain, Yves, Peuchmaur, Michel, Lehn, Jean-Marie, Lehn, Pierre, Luton, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BGTC congenital diaphragmatic hernia Disease Models, Animal fetal gene therapy fetal sheep Fetus - metabolism Fetus - pathology Fibroblast Growth Factor 7 - genetics Fibroblast Growth Factor 7 - metabolism Fibroblast Growth Factor 7 - therapeutic use Gene Expression Regulation, Developmental Gene therapy Hernia, Diaphragmatic - therapy Hernias, Diaphragmatic, Congenital in utero KGF Lung - embryology Lung - pathology Organ Size Pulmonary Alveoli - pathology Pulmonary Surfactant-Associated Protein B - metabolism Reverse Transcriptase Polymerase Chain Reaction Sheep Trachea - blood supply transfection Transfection - methods
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