Synthesis and biological evaluation of indole-chalcone derivatives as β-amyloid imaging probe

A series of novel indole-chalcone derivatives were synthesized and evaluated as Aβ imaging probes. A series of chaclone derivatives containing an indole moiety were evaluated in competitive binding assays with Aβ 1-42 aggregates versus [ 125I]IMPY. The affinity of these compounds ranged from 4.46 to...

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