Mid-term results of Autologous Matrix-Induced Chondrogenesis for treatment of focal cartilage defects in the knee
Articular cartilage defects heal poorly. Autologous Matrix-Induced Chondrogenesis (AMIC) is an innovative treatment for localized full-thickness cartilage defects combining the well-known microfracturing with collagen scaffold and fibrin glue. The purpose of this prospective study was to evaluate th...
Gespeichert in:
| Veröffentlicht in: | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA sports traumatology, arthroscopy : official journal of the ESSKA, 2010-11, Vol.18 (11), p.1456-1464 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1464 |
|---|---|
| container_issue | 11 |
| container_start_page | 1456 |
| container_title | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA |
| container_volume | 18 |
| creator | Gille, J. Schuseil, E. Wimmer, J. Gellissen, J. Schulz, A. P. Behrens, P. |
| description | Articular cartilage defects heal poorly. Autologous Matrix-Induced Chondrogenesis (AMIC) is an innovative treatment for localized full-thickness cartilage defects combining the well-known microfracturing with collagen scaffold and fibrin glue. The purpose of this prospective study was to evaluate the medium-term results of this enhanced microfracture technique for the treatment of chondral lesions of the knee. Thirty-two chondral lesions in 27 patients were treated with AMIC. Within the context of clinical follow-up, these patients were evaluated for up to 5 years after the intervention. Five different scores (Meyer score, Tegner score, Lysholm score, ICRS score, Cincinatti score) as well as radiographs were used for outcome analysis. Articular resurfacing was assessed by magnetic resonance imaging (MRI). The average age of patients (11 females, 16 males; mean body mass index 26, range 20–32) was 37 years (range 16–50 years). The mean defect size of the chondral lesions was 4.2 cm
2
(range 1.3–8.8 cm
2
). All defects were classified as grade IV according to the Outerbridge classification. The follow-up period was between 24 and 62 months with a mean of 37 months. Twenty out of 23 individuals (87%) questioned were subjectively highly satisfied with the results after surgery. Significant improvement (
P
|
| doi_str_mv | 10.1007/s00167-010-1042-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_883013976</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>759522316</sourcerecordid><originalsourceid>FETCH-LOGICAL-c468t-c1b2de20eae7c7fdc1d30d065ddb9f3e039fec1e3fc71d7e758a09e0fe81cc453</originalsourceid><addsrcrecordid>eNqFkU1LHTEUhkOx1FvbH-BGghtXaU-SmcnMUi7WCko37TrkJifX0ZlEkwzov29ur22hIF3l63mfcHgJOebwiQOozxmAd4oBB8ahEUy-ISveSMmUbNQBWcFQLwW03SF5n_MdQN02wztyKIALBUqsyOPN6FjBNNOEeZlKptHT86XEKW7jkumNKWl8YlfBLRYdXd_G4FLcYsA8ZupjoiWhKTOGskv6aM1ErUllnMwWqUOPtkrHQMst0vuA-IG89WbK-PFlPSI_vlx8X39l198ur9bn18w2XV-Y5RvhUAAaVFZ5Z7mT4KBrndsMXiLIoao5Sm8VdwpV2xsYEDz23NqmlUfkbO99SPFxwVz0PGaL02QC1sl030vgclDdf0nVDq0Qku_I03_Iu7ikUMfQPahOgOKqQnwP2RRzTuj1Qxpnk541B73rTe970_Dr3Agta-bkRbxsZnR_Er-LqoDYA7k-hS2mvz-_bv0JdM6kOQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>807620717</pqid></control><display><type>article</type><title>Mid-term results of Autologous Matrix-Induced Chondrogenesis for treatment of focal cartilage defects in the knee</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>SpringerLink Journals - AutoHoldings</source><creator>Gille, J. ; Schuseil, E. ; Wimmer, J. ; Gellissen, J. ; Schulz, A. P. ; Behrens, P.</creator><creatorcontrib>Gille, J. ; Schuseil, E. ; Wimmer, J. ; Gellissen, J. ; Schulz, A. P. ; Behrens, P.</creatorcontrib><description>Articular cartilage defects heal poorly. Autologous Matrix-Induced Chondrogenesis (AMIC) is an innovative treatment for localized full-thickness cartilage defects combining the well-known microfracturing with collagen scaffold and fibrin glue. The purpose of this prospective study was to evaluate the medium-term results of this enhanced microfracture technique for the treatment of chondral lesions of the knee. Thirty-two chondral lesions in 27 patients were treated with AMIC. Within the context of clinical follow-up, these patients were evaluated for up to 5 years after the intervention. Five different scores (Meyer score, Tegner score, Lysholm score, ICRS score, Cincinatti score) as well as radiographs were used for outcome analysis. Articular resurfacing was assessed by magnetic resonance imaging (MRI). The average age of patients (11 females, 16 males; mean body mass index 26, range 20–32) was 37 years (range 16–50 years). The mean defect size of the chondral lesions was 4.2 cm
2
(range 1.3–8.8 cm
2
). All defects were classified as grade IV according to the Outerbridge classification. The follow-up period was between 24 and 62 months with a mean of 37 months. Twenty out of 23 individuals (87%) questioned were subjectively highly satisfied with the results after surgery. Significant improvement (
P
< 0.05) of all scores was observed as early as 12 months after AMIC, and further increased values were notable up to 24 months postoperatively. MRI analysis showed moderate to complete filling with a normal to incidentally hyperintense signal in most cases. Results did not show a clinical impact of patient’s age at the time of operation, body mass index and number of previous operations (n.s.). In contrast, males showed significant higher values in the ICRS score compared to their female counterparts. AMIC is an effective and safe method of treating symptomatic full-thickness chondral defects of the knee in appropriately selected cases. However, further studies with long-term follow-up are needed to determine whether the grafted area will maintain structural and functional integrity over time.</description><identifier>ISSN: 0942-2056</identifier><identifier>EISSN: 1433-7347</identifier><identifier>DOI: 10.1007/s00167-010-1042-3</identifier><identifier>PMID: 20127072</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adhesives ; Adolescent ; Adult ; Age ; Age Factors ; Analysis ; Arthritis ; Arthroplasty, Subchondral ; Arthroscopy ; Body mass ; Body mass index ; Bone marrow ; Bone surgery ; Cartilage ; Cartilage (articular) ; Cartilage, Articular - injuries ; Cartilage, Articular - surgery ; Chondrocytes - transplantation ; Chondrogenesis ; Chondrogenesis - physiology ; Classification ; Collagen ; Connective tissue ; Defects ; Female ; fibrin ; Fibrin Tissue Adhesive - pharmacology ; Follow-Up Studies ; Fractures ; Humans ; Injury Severity Score ; Knee ; Knee Injuries - diagnosis ; Knee Injuries - surgery ; Knees ; Magnetic resonance imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Orthopedics ; Osteoarthritis ; Patients ; Prospective Studies ; Radiography ; Risk Assessment ; scaffolds ; scoring ; Sex Factors ; Statistics, Nonparametric ; Stem cells ; Structure-function relationships ; Surgery ; Time Factors ; Tissue engineering ; Tissue Engineering - methods ; Tissue Scaffolds ; Tomography ; Transplantation, Autologous ; Treatment Outcome ; Young Adult</subject><ispartof>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2010-11, Vol.18 (11), p.1456-1464</ispartof><rights>Springer-Verlag 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-c1b2de20eae7c7fdc1d30d065ddb9f3e039fec1e3fc71d7e758a09e0fe81cc453</citedby><cites>FETCH-LOGICAL-c468t-c1b2de20eae7c7fdc1d30d065ddb9f3e039fec1e3fc71d7e758a09e0fe81cc453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00167-010-1042-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00167-010-1042-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20127072$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gille, J.</creatorcontrib><creatorcontrib>Schuseil, E.</creatorcontrib><creatorcontrib>Wimmer, J.</creatorcontrib><creatorcontrib>Gellissen, J.</creatorcontrib><creatorcontrib>Schulz, A. P.</creatorcontrib><creatorcontrib>Behrens, P.</creatorcontrib><title>Mid-term results of Autologous Matrix-Induced Chondrogenesis for treatment of focal cartilage defects in the knee</title><title>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</title><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><description>Articular cartilage defects heal poorly. Autologous Matrix-Induced Chondrogenesis (AMIC) is an innovative treatment for localized full-thickness cartilage defects combining the well-known microfracturing with collagen scaffold and fibrin glue. The purpose of this prospective study was to evaluate the medium-term results of this enhanced microfracture technique for the treatment of chondral lesions of the knee. Thirty-two chondral lesions in 27 patients were treated with AMIC. Within the context of clinical follow-up, these patients were evaluated for up to 5 years after the intervention. Five different scores (Meyer score, Tegner score, Lysholm score, ICRS score, Cincinatti score) as well as radiographs were used for outcome analysis. Articular resurfacing was assessed by magnetic resonance imaging (MRI). The average age of patients (11 females, 16 males; mean body mass index 26, range 20–32) was 37 years (range 16–50 years). The mean defect size of the chondral lesions was 4.2 cm
2
(range 1.3–8.8 cm
2
). All defects were classified as grade IV according to the Outerbridge classification. The follow-up period was between 24 and 62 months with a mean of 37 months. Twenty out of 23 individuals (87%) questioned were subjectively highly satisfied with the results after surgery. Significant improvement (
P
< 0.05) of all scores was observed as early as 12 months after AMIC, and further increased values were notable up to 24 months postoperatively. MRI analysis showed moderate to complete filling with a normal to incidentally hyperintense signal in most cases. Results did not show a clinical impact of patient’s age at the time of operation, body mass index and number of previous operations (n.s.). In contrast, males showed significant higher values in the ICRS score compared to their female counterparts. AMIC is an effective and safe method of treating symptomatic full-thickness chondral defects of the knee in appropriately selected cases. However, further studies with long-term follow-up are needed to determine whether the grafted area will maintain structural and functional integrity over time.</description><subject>Adhesives</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Analysis</subject><subject>Arthritis</subject><subject>Arthroplasty, Subchondral</subject><subject>Arthroscopy</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Bone marrow</subject><subject>Bone surgery</subject><subject>Cartilage</subject><subject>Cartilage (articular)</subject><subject>Cartilage, Articular - injuries</subject><subject>Cartilage, Articular - surgery</subject><subject>Chondrocytes - transplantation</subject><subject>Chondrogenesis</subject><subject>Chondrogenesis - physiology</subject><subject>Classification</subject><subject>Collagen</subject><subject>Connective tissue</subject><subject>Defects</subject><subject>Female</subject><subject>fibrin</subject><subject>Fibrin Tissue Adhesive - pharmacology</subject><subject>Follow-Up Studies</subject><subject>Fractures</subject><subject>Humans</subject><subject>Injury Severity Score</subject><subject>Knee</subject><subject>Knee Injuries - diagnosis</subject><subject>Knee Injuries - surgery</subject><subject>Knees</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Orthopedics</subject><subject>Osteoarthritis</subject><subject>Patients</subject><subject>Prospective Studies</subject><subject>Radiography</subject><subject>Risk Assessment</subject><subject>scaffolds</subject><subject>scoring</subject><subject>Sex Factors</subject><subject>Statistics, Nonparametric</subject><subject>Stem cells</subject><subject>Structure-function relationships</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Tissue engineering</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Scaffolds</subject><subject>Tomography</subject><subject>Transplantation, Autologous</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0942-2056</issn><issn>1433-7347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkU1LHTEUhkOx1FvbH-BGghtXaU-SmcnMUi7WCko37TrkJifX0ZlEkwzov29ur22hIF3l63mfcHgJOebwiQOozxmAd4oBB8ahEUy-ISveSMmUbNQBWcFQLwW03SF5n_MdQN02wztyKIALBUqsyOPN6FjBNNOEeZlKptHT86XEKW7jkumNKWl8YlfBLRYdXd_G4FLcYsA8ZupjoiWhKTOGskv6aM1ErUllnMwWqUOPtkrHQMst0vuA-IG89WbK-PFlPSI_vlx8X39l198ur9bn18w2XV-Y5RvhUAAaVFZ5Z7mT4KBrndsMXiLIoao5Sm8VdwpV2xsYEDz23NqmlUfkbO99SPFxwVz0PGaL02QC1sl030vgclDdf0nVDq0Qku_I03_Iu7ikUMfQPahOgOKqQnwP2RRzTuj1Qxpnk541B73rTe970_Dr3Agta-bkRbxsZnR_Er-LqoDYA7k-hS2mvz-_bv0JdM6kOQ</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Gille, J.</creator><creator>Schuseil, E.</creator><creator>Wimmer, J.</creator><creator>Gellissen, J.</creator><creator>Schulz, A. P.</creator><creator>Behrens, P.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>20101101</creationdate><title>Mid-term results of Autologous Matrix-Induced Chondrogenesis for treatment of focal cartilage defects in the knee</title><author>Gille, J. ; Schuseil, E. ; Wimmer, J. ; Gellissen, J. ; Schulz, A. P. ; Behrens, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-c1b2de20eae7c7fdc1d30d065ddb9f3e039fec1e3fc71d7e758a09e0fe81cc453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adhesives</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Analysis</topic><topic>Arthritis</topic><topic>Arthroplasty, Subchondral</topic><topic>Arthroscopy</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Bone marrow</topic><topic>Bone surgery</topic><topic>Cartilage</topic><topic>Cartilage (articular)</topic><topic>Cartilage, Articular - injuries</topic><topic>Cartilage, Articular - surgery</topic><topic>Chondrocytes - transplantation</topic><topic>Chondrogenesis</topic><topic>Chondrogenesis - physiology</topic><topic>Classification</topic><topic>Collagen</topic><topic>Connective tissue</topic><topic>Defects</topic><topic>Female</topic><topic>fibrin</topic><topic>Fibrin Tissue Adhesive - pharmacology</topic><topic>Follow-Up Studies</topic><topic>Fractures</topic><topic>Humans</topic><topic>Injury Severity Score</topic><topic>Knee</topic><topic>Knee Injuries - diagnosis</topic><topic>Knee Injuries - surgery</topic><topic>Knees</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Orthopedics</topic><topic>Osteoarthritis</topic><topic>Patients</topic><topic>Prospective Studies</topic><topic>Radiography</topic><topic>Risk Assessment</topic><topic>scaffolds</topic><topic>scoring</topic><topic>Sex Factors</topic><topic>Statistics, Nonparametric</topic><topic>Stem cells</topic><topic>Structure-function relationships</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Tissue engineering</topic><topic>Tissue Engineering - methods</topic><topic>Tissue Scaffolds</topic><topic>Tomography</topic><topic>Transplantation, Autologous</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gille, J.</creatorcontrib><creatorcontrib>Schuseil, E.</creatorcontrib><creatorcontrib>Wimmer, J.</creatorcontrib><creatorcontrib>Gellissen, J.</creatorcontrib><creatorcontrib>Schulz, A. P.</creatorcontrib><creatorcontrib>Behrens, P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gille, J.</au><au>Schuseil, E.</au><au>Wimmer, J.</au><au>Gellissen, J.</au><au>Schulz, A. P.</au><au>Behrens, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mid-term results of Autologous Matrix-Induced Chondrogenesis for treatment of focal cartilage defects in the knee</atitle><jtitle>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</jtitle><stitle>Knee Surg Sports Traumatol Arthrosc</stitle><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>18</volume><issue>11</issue><spage>1456</spage><epage>1464</epage><pages>1456-1464</pages><issn>0942-2056</issn><eissn>1433-7347</eissn><abstract>Articular cartilage defects heal poorly. Autologous Matrix-Induced Chondrogenesis (AMIC) is an innovative treatment for localized full-thickness cartilage defects combining the well-known microfracturing with collagen scaffold and fibrin glue. The purpose of this prospective study was to evaluate the medium-term results of this enhanced microfracture technique for the treatment of chondral lesions of the knee. Thirty-two chondral lesions in 27 patients were treated with AMIC. Within the context of clinical follow-up, these patients were evaluated for up to 5 years after the intervention. Five different scores (Meyer score, Tegner score, Lysholm score, ICRS score, Cincinatti score) as well as radiographs were used for outcome analysis. Articular resurfacing was assessed by magnetic resonance imaging (MRI). The average age of patients (11 females, 16 males; mean body mass index 26, range 20–32) was 37 years (range 16–50 years). The mean defect size of the chondral lesions was 4.2 cm
2
(range 1.3–8.8 cm
2
). All defects were classified as grade IV according to the Outerbridge classification. The follow-up period was between 24 and 62 months with a mean of 37 months. Twenty out of 23 individuals (87%) questioned were subjectively highly satisfied with the results after surgery. Significant improvement (
P
< 0.05) of all scores was observed as early as 12 months after AMIC, and further increased values were notable up to 24 months postoperatively. MRI analysis showed moderate to complete filling with a normal to incidentally hyperintense signal in most cases. Results did not show a clinical impact of patient’s age at the time of operation, body mass index and number of previous operations (n.s.). In contrast, males showed significant higher values in the ICRS score compared to their female counterparts. AMIC is an effective and safe method of treating symptomatic full-thickness chondral defects of the knee in appropriately selected cases. However, further studies with long-term follow-up are needed to determine whether the grafted area will maintain structural and functional integrity over time.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20127072</pmid><doi>10.1007/s00167-010-1042-3</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0942-2056 |
| ispartof | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2010-11, Vol.18 (11), p.1456-1464 |
| issn | 0942-2056 1433-7347 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_883013976 |
| source | MEDLINE; Access via Wiley Online Library; SpringerLink Journals - AutoHoldings |
| subjects | Adhesives Adolescent Adult Age Age Factors Analysis Arthritis Arthroplasty, Subchondral Arthroscopy Body mass Body mass index Bone marrow Bone surgery Cartilage Cartilage (articular) Cartilage, Articular - injuries Cartilage, Articular - surgery Chondrocytes - transplantation Chondrogenesis Chondrogenesis - physiology Classification Collagen Connective tissue Defects Female fibrin Fibrin Tissue Adhesive - pharmacology Follow-Up Studies Fractures Humans Injury Severity Score Knee Knee Injuries - diagnosis Knee Injuries - surgery Knees Magnetic resonance imaging Male Medicine Medicine & Public Health Middle Aged Orthopedics Osteoarthritis Patients Prospective Studies Radiography Risk Assessment scaffolds scoring Sex Factors Statistics, Nonparametric Stem cells Structure-function relationships Surgery Time Factors Tissue engineering Tissue Engineering - methods Tissue Scaffolds Tomography Transplantation, Autologous Treatment Outcome Young Adult |
| title | Mid-term results of Autologous Matrix-Induced Chondrogenesis for treatment of focal cartilage defects in the knee |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T22%3A31%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mid-term%20results%20of%20Autologous%20Matrix-Induced%20Chondrogenesis%20for%20treatment%20of%20focal%20cartilage%20defects%20in%20the%20knee&rft.jtitle=Knee%20surgery,%20sports%20traumatology,%20arthroscopy%20:%20official%20journal%20of%20the%20ESSKA&rft.au=Gille,%20J.&rft.date=2010-11-01&rft.volume=18&rft.issue=11&rft.spage=1456&rft.epage=1464&rft.pages=1456-1464&rft.issn=0942-2056&rft.eissn=1433-7347&rft_id=info:doi/10.1007/s00167-010-1042-3&rft_dat=%3Cproquest_cross%3E759522316%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=807620717&rft_id=info:pmid/20127072&rfr_iscdi=true |