Regenerative behavior of biomineral/agarose composite gels as bone grafting materials in rat cranial defects
The main objective of this study was to evaluate the biological behavior of Hydroxyapatite (HAp)/agarose and calcium carbonate (CaCO3)/agarose composite gels by an alternate soaking process used for the treatment of surgically produced bone defects in rat cranium. We designed the following four grou...
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| Veröffentlicht in: | Journal of biomedical materials research. Part A 2010-06, Vol.93A (3), p.965-975 |
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| container_title | Journal of biomedical materials research. Part A |
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| creator | Suzawa, Yoshika Funaki, Takafumi Watanabe, Junji Iwai, Soichi Yura, Yoshiaki Nakano, Takayoshi Umakoshi, Yukichi Akashi, Mitsuru |
| description | The main objective of this study was to evaluate the biological behavior of Hydroxyapatite (HAp)/agarose and calcium carbonate (CaCO3)/agarose composite gels by an alternate soaking process used for the treatment of surgically produced bone defects in rat cranium. We designed the following four groups: (i) HAp (HAp/agarose composite gel), (ii) CaCO3 (CaCO3/agarose composite gel), (iii) Agarose (bare agarose gel), and (iv) Defect (no filling materials). We subdivided (i) (ii) (iii) into two application types as a (I) Homogenized Group (homogenized materials) and a (II) Disk Group (disk shaped materials). We assessed samples by radiological and histological analyses 0, 4, and 8 weeks after implantation. The results indicated that the composite gels showed higher radiopacity in microfocus‐computed tomography (μCT) images and showed higher volume in quantitative analyses using Dual Energy X‐ray Absorptiometry (DEXA) and Peripheral Quantitative Computed Tomography (pQCT) than the Agarose and Defect groups. The histological examination showed characteristic images due to each application form. Consequently, HAp and CaCO3/agarose composite gels can be expected to accelerate the speed of producing more new bone associated with osteogenesis. These novel biomaterials play an important role as an alternative biocompatible and biodegradable bone grafting filler material for autogenous bone. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010 |
| doi_str_mv | 10.1002/jbm.a.32518 |
| format | Article |
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We designed the following four groups: (i) HAp (HAp/agarose composite gel), (ii) CaCO3 (CaCO3/agarose composite gel), (iii) Agarose (bare agarose gel), and (iv) Defect (no filling materials). We subdivided (i) (ii) (iii) into two application types as a (I) Homogenized Group (homogenized materials) and a (II) Disk Group (disk shaped materials). We assessed samples by radiological and histological analyses 0, 4, and 8 weeks after implantation. The results indicated that the composite gels showed higher radiopacity in microfocus‐computed tomography (μCT) images and showed higher volume in quantitative analyses using Dual Energy X‐ray Absorptiometry (DEXA) and Peripheral Quantitative Computed Tomography (pQCT) than the Agarose and Defect groups. The histological examination showed characteristic images due to each application form. Consequently, HAp and CaCO3/agarose composite gels can be expected to accelerate the speed of producing more new bone associated with osteogenesis. These novel biomaterials play an important role as an alternative biocompatible and biodegradable bone grafting filler material for autogenous bone. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010</description><identifier>ISSN: 1549-3296</identifier><identifier>ISSN: 1552-4965</identifier><identifier>EISSN: 1552-4965</identifier><identifier>DOI: 10.1002/jbm.a.32518</identifier><identifier>PMID: 19722281</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Absorptiometry, Photon ; agarose composite gel ; Animals ; application form ; Biocompatible Materials - pharmacology ; Biological and medical sciences ; bone grafting material ; Bone Regeneration - drug effects ; Bone Transplantation - methods ; Calcium Carbonate - pharmacology ; Durapatite - pharmacology ; Gels ; hydroxyapatite (HAp) and calcium carbonate (CaCO3) ; Implants, Experimental ; Male ; Medical sciences ; Microscopy, Electron, Scanning ; Models, Biological ; Orthopedic surgery ; rat cranium ; Rats ; Rats, Wistar ; Sepharose - pharmacology ; Skull - diagnostic imaging ; Skull - drug effects ; Skull - pathology ; Surface Properties - drug effects ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments ; Tomography, X-Ray Computed ; X-Ray Diffraction</subject><ispartof>Journal of biomedical materials research. 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Part A</title><addtitle>J. Biomed. Mater. Res</addtitle><description>The main objective of this study was to evaluate the biological behavior of Hydroxyapatite (HAp)/agarose and calcium carbonate (CaCO3)/agarose composite gels by an alternate soaking process used for the treatment of surgically produced bone defects in rat cranium. We designed the following four groups: (i) HAp (HAp/agarose composite gel), (ii) CaCO3 (CaCO3/agarose composite gel), (iii) Agarose (bare agarose gel), and (iv) Defect (no filling materials). We subdivided (i) (ii) (iii) into two application types as a (I) Homogenized Group (homogenized materials) and a (II) Disk Group (disk shaped materials). We assessed samples by radiological and histological analyses 0, 4, and 8 weeks after implantation. The results indicated that the composite gels showed higher radiopacity in microfocus‐computed tomography (μCT) images and showed higher volume in quantitative analyses using Dual Energy X‐ray Absorptiometry (DEXA) and Peripheral Quantitative Computed Tomography (pQCT) than the Agarose and Defect groups. The histological examination showed characteristic images due to each application form. Consequently, HAp and CaCO3/agarose composite gels can be expected to accelerate the speed of producing more new bone associated with osteogenesis. These novel biomaterials play an important role as an alternative biocompatible and biodegradable bone grafting filler material for autogenous bone. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010</description><subject>Absorptiometry, Photon</subject><subject>agarose composite gel</subject><subject>Animals</subject><subject>application form</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biological and medical sciences</subject><subject>bone grafting material</subject><subject>Bone Regeneration - drug effects</subject><subject>Bone Transplantation - methods</subject><subject>Calcium Carbonate - pharmacology</subject><subject>Durapatite - pharmacology</subject><subject>Gels</subject><subject>hydroxyapatite (HAp) and calcium carbonate (CaCO3)</subject><subject>Implants, Experimental</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Models, Biological</subject><subject>Orthopedic surgery</subject><subject>rat cranium</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sepharose - pharmacology</subject><subject>Skull - diagnostic imaging</subject><subject>Skull - drug effects</subject><subject>Skull - pathology</subject><subject>Surface Properties - drug effects</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. Equipments</subject><subject>Tomography, X-Ray Computed</subject><subject>X-Ray Diffraction</subject><issn>1549-3296</issn><issn>1552-4965</issn><issn>1552-4965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctv1DAQxiMEog84cUe-IA5Vtn7Ejn2kFbRAy0sgjtbYmSwuSbzY2UL_e7zsUm7AyZ75fvONNF9VPWJ0wSjlx1duXMBCcMn0nWqfScnrxih5d_NvTC24UXvVQc5XBVZU8vvVHjMt51yz_Wr4gEucMMEcrpE4_ALXISYSe-JCHMNGGY5hCSlmJD6Oq5jDjGSJQyaQiYtTKRL0c5iWZIQZU4AihYkUS-ITTKUmHfbo5_ygutcXFR_u3sPq04vnH0_P64u3Zy9Pn13UXnKta9Y20PTUadBeauYMaOoZ9k5Sb6TstVOl72nrUHoqDNOdNlx1WivWdkqKw-rp1neV4rc15tmOIXscBpgwrrPVWlAmtPkPUhlZOKP_SbZCqEYJagp5tCV9OVpO2NtVCiOkG8uo3SRmS2IW7K_ECv1457t2I3Z_2F1EBXiyAyB7GPpyUh_yLcd521La0MKxLfc9DHjzt5321cnl7-X1dibkGX_czkD6alUrWmk_vzmzl-bk3Xv9-txy8RPykr0s</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Suzawa, Yoshika</creator><creator>Funaki, Takafumi</creator><creator>Watanabe, Junji</creator><creator>Iwai, Soichi</creator><creator>Yura, Yoshiaki</creator><creator>Nakano, Takayoshi</creator><creator>Umakoshi, Yukichi</creator><creator>Akashi, Mitsuru</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7QP</scope></search><sort><creationdate>20100601</creationdate><title>Regenerative behavior of biomineral/agarose composite gels as bone grafting materials in rat cranial defects</title><author>Suzawa, Yoshika ; Funaki, Takafumi ; Watanabe, Junji ; Iwai, Soichi ; Yura, Yoshiaki ; Nakano, Takayoshi ; Umakoshi, Yukichi ; Akashi, Mitsuru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5288-174a4f0b8a8c581b9a80c1efb50c955f8b6c58c07be5c03918d8926d88617d653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Absorptiometry, Photon</topic><topic>agarose composite gel</topic><topic>Animals</topic><topic>application form</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Biological and medical sciences</topic><topic>bone grafting material</topic><topic>Bone Regeneration - drug effects</topic><topic>Bone Transplantation - methods</topic><topic>Calcium Carbonate - pharmacology</topic><topic>Durapatite - pharmacology</topic><topic>Gels</topic><topic>hydroxyapatite (HAp) and calcium carbonate (CaCO3)</topic><topic>Implants, Experimental</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Models, Biological</topic><topic>Orthopedic surgery</topic><topic>rat cranium</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sepharose - pharmacology</topic><topic>Skull - diagnostic imaging</topic><topic>Skull - drug effects</topic><topic>Skull - pathology</topic><topic>Surface Properties - drug effects</topic><topic>Surgery (general aspects). 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Res</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>93A</volume><issue>3</issue><spage>965</spage><epage>975</epage><pages>965-975</pages><issn>1549-3296</issn><issn>1552-4965</issn><eissn>1552-4965</eissn><abstract>The main objective of this study was to evaluate the biological behavior of Hydroxyapatite (HAp)/agarose and calcium carbonate (CaCO3)/agarose composite gels by an alternate soaking process used for the treatment of surgically produced bone defects in rat cranium. We designed the following four groups: (i) HAp (HAp/agarose composite gel), (ii) CaCO3 (CaCO3/agarose composite gel), (iii) Agarose (bare agarose gel), and (iv) Defect (no filling materials). We subdivided (i) (ii) (iii) into two application types as a (I) Homogenized Group (homogenized materials) and a (II) Disk Group (disk shaped materials). We assessed samples by radiological and histological analyses 0, 4, and 8 weeks after implantation. The results indicated that the composite gels showed higher radiopacity in microfocus‐computed tomography (μCT) images and showed higher volume in quantitative analyses using Dual Energy X‐ray Absorptiometry (DEXA) and Peripheral Quantitative Computed Tomography (pQCT) than the Agarose and Defect groups. The histological examination showed characteristic images due to each application form. Consequently, HAp and CaCO3/agarose composite gels can be expected to accelerate the speed of producing more new bone associated with osteogenesis. These novel biomaterials play an important role as an alternative biocompatible and biodegradable bone grafting filler material for autogenous bone. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19722281</pmid><doi>10.1002/jbm.a.32518</doi><tpages>11</tpages></addata></record> |
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| subjects | Absorptiometry, Photon agarose composite gel Animals application form Biocompatible Materials - pharmacology Biological and medical sciences bone grafting material Bone Regeneration - drug effects Bone Transplantation - methods Calcium Carbonate - pharmacology Durapatite - pharmacology Gels hydroxyapatite (HAp) and calcium carbonate (CaCO3) Implants, Experimental Male Medical sciences Microscopy, Electron, Scanning Models, Biological Orthopedic surgery rat cranium Rats Rats, Wistar Sepharose - pharmacology Skull - diagnostic imaging Skull - drug effects Skull - pathology Surface Properties - drug effects Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Tomography, X-Ray Computed X-Ray Diffraction |
| title | Regenerative behavior of biomineral/agarose composite gels as bone grafting materials in rat cranial defects |
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