Design and characterization of PEGylated terpolymer biomaterials
A terpolymer copolymerized from hexyl methacrylate, methyl methacrylate, and poly(ethylene glycol) methacrylate (PEGMA) was synthesized. Polymers containing 0–25 mol % PEGMA were studied. As the mole fraction of PEGMA in the polymer chains increased, the material becomes more hydrophilic as observed...
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| Veröffentlicht in: | Journal of biomedical materials research. Part A 2010-09, Vol.94A (4), p.1294-1302 |
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| creator | Heath, Daniel E. Cooper, Stuart L. |
| description | A terpolymer copolymerized from hexyl methacrylate, methyl methacrylate, and poly(ethylene glycol) methacrylate (PEGMA) was synthesized. Polymers containing 0–25 mol % PEGMA were studied. As the mole fraction of PEGMA in the polymer chains increased, the material becomes more hydrophilic as observed by a decrease in the contact angle of water (81°–68°) and an increase in the equilibrium water absorption (0.7–237 wt %). Furthermore, the material shows nonfouling interfacial properties through resistance to protein adsorption and cellular attachment. A total of 1.2 μg/cm2 fibrinogen, 18,000 HUVECs/cm2, and 3,000,000 platelets/cm2 adsorbed or adhered on non‐PEGylated materials, whereas very low amounts of protein or cells were observed on materials containing ≥15 mol % PEGMA. Being thermoplastic, the polymer can be processed postsynthesis. To illustrate the processing capabilities of the material, polymer solutions were electrospun into nonwoven fibrous scaffold, which also retained their nonfouling character. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010. |
| doi_str_mv | 10.1002/jbm.a.32811 |
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Polymers containing 0–25 mol % PEGMA were studied. As the mole fraction of PEGMA in the polymer chains increased, the material becomes more hydrophilic as observed by a decrease in the contact angle of water (81°–68°) and an increase in the equilibrium water absorption (0.7–237 wt %). Furthermore, the material shows nonfouling interfacial properties through resistance to protein adsorption and cellular attachment. A total of 1.2 μg/cm2 fibrinogen, 18,000 HUVECs/cm2, and 3,000,000 platelets/cm2 adsorbed or adhered on non‐PEGylated materials, whereas very low amounts of protein or cells were observed on materials containing ≥15 mol % PEGMA. Being thermoplastic, the polymer can be processed postsynthesis. To illustrate the processing capabilities of the material, polymer solutions were electrospun into nonwoven fibrous scaffold, which also retained their nonfouling character. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.</description><identifier>ISSN: 1549-3296</identifier><identifier>ISSN: 1552-4965</identifier><identifier>EISSN: 1552-4965</identifier><identifier>DOI: 10.1002/jbm.a.32811</identifier><identifier>PMID: 20694997</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adsorption - drug effects ; Adult ; Applied sciences ; Biocompatible Materials - chemical synthesis ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacology ; Biological and medical sciences ; Biological properties ; Biomedical materials ; blood compatible ; Blood Platelets - drug effects ; Blood Platelets - ultrastructure ; Cell Adhesion - drug effects ; Cell Proliferation - drug effects ; Cellular ; Contact angle ; Electrospinning ; Endothelial Cells - cytology ; Endothelial Cells - drug effects ; Exact sciences and technology ; Fibrinogen - metabolism ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Methacrylates - chemical synthesis ; Methacrylates - chemistry ; Methacrylates - pharmacology ; Methylmethacrylate - chemical synthesis ; Methylmethacrylate - chemistry ; Methylmethacrylate - pharmacology ; Microscopy, Fluorescence ; Molecular Weight ; nonfouling ; Organic polymers ; Physicochemistry of polymers ; Platelet Adhesiveness - drug effects ; poly(ethylene glycol) ; Polyethylene Glycols - chemical synthesis ; Polyethylene Glycols - chemistry ; Polyethylene Glycols - pharmacology ; Polymethyl methacrylates ; Properties and characterization ; Reproduction ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgical implants ; Technology. Biomaterials. Equipments ; terpolymer ; Terpolymers ; Umbilical Veins - cytology ; Water - chemistry</subject><ispartof>Journal of biomedical materials research. 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Part A</title><addtitle>J. Biomed. Mater. Res</addtitle><description>A terpolymer copolymerized from hexyl methacrylate, methyl methacrylate, and poly(ethylene glycol) methacrylate (PEGMA) was synthesized. Polymers containing 0–25 mol % PEGMA were studied. As the mole fraction of PEGMA in the polymer chains increased, the material becomes more hydrophilic as observed by a decrease in the contact angle of water (81°–68°) and an increase in the equilibrium water absorption (0.7–237 wt %). Furthermore, the material shows nonfouling interfacial properties through resistance to protein adsorption and cellular attachment. A total of 1.2 μg/cm2 fibrinogen, 18,000 HUVECs/cm2, and 3,000,000 platelets/cm2 adsorbed or adhered on non‐PEGylated materials, whereas very low amounts of protein or cells were observed on materials containing ≥15 mol % PEGMA. Being thermoplastic, the polymer can be processed postsynthesis. To illustrate the processing capabilities of the material, polymer solutions were electrospun into nonwoven fibrous scaffold, which also retained their nonfouling character. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.</description><subject>Adsorption - drug effects</subject><subject>Adult</subject><subject>Applied sciences</subject><subject>Biocompatible Materials - chemical synthesis</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Biological properties</subject><subject>Biomedical materials</subject><subject>blood compatible</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - ultrastructure</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Cellular</subject><subject>Contact angle</subject><subject>Electrospinning</subject><subject>Endothelial Cells - cytology</subject><subject>Endothelial Cells - drug effects</subject><subject>Exact sciences and technology</subject><subject>Fibrinogen - metabolism</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methacrylates - chemical synthesis</subject><subject>Methacrylates - chemistry</subject><subject>Methacrylates - pharmacology</subject><subject>Methylmethacrylate - chemical synthesis</subject><subject>Methylmethacrylate - chemistry</subject><subject>Methylmethacrylate - pharmacology</subject><subject>Microscopy, Fluorescence</subject><subject>Molecular Weight</subject><subject>nonfouling</subject><subject>Organic polymers</subject><subject>Physicochemistry of polymers</subject><subject>Platelet Adhesiveness - drug effects</subject><subject>poly(ethylene glycol)</subject><subject>Polyethylene Glycols - chemical synthesis</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyethylene Glycols - pharmacology</subject><subject>Polymethyl methacrylates</subject><subject>Properties and characterization</subject><subject>Reproduction</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgical implants</subject><subject>Technology. Biomaterials. Equipments</subject><subject>terpolymer</subject><subject>Terpolymers</subject><subject>Umbilical Veins - cytology</subject><subject>Water - chemistry</subject><issn>1549-3296</issn><issn>1552-4965</issn><issn>1552-4965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ctvEzEQB2ALgegDTtyrvSAqVRs89vp1gz4SQOVx4HG0vM5s63Yfwd6oDX89DknLrT2NZX0zY_lHyCugE6CUvb2qu4mbcKYBnpBdEIKVlZHi6fpcmZIzI3fIXkpXGUsq2HOyw6g0lTFql7w7xRQu-sL188Jfuuj8iDH8cWMY-mJoim9ns1XrRpwX-X4xtKsOY1GHoXNr59r0gjxrcsGX27pPfkzPvp98KM-_zj6evD8vfWUElGiM4Qq80XP0mtdMUyE5r70yTDOoG1BU0Sa_z6DWgmlsWMNBgKukkoB8n7zZzF3E4fcS02i7kDy2retxWCarNafAtVCPS2mE0gLoo1JV2uQvZCLLwwclSAVMKMpYpkcb6uOQUsTGLmLoXFxZoHYdmM2BWWf_BZb1wXbwsu5wfm_vEsrg9Ra45F3bRNf7kP47DrJiXGYHG3cTWlw9tNN-Ov58t7zc9IQ04u19j4vXViquhP31ZWan8qdkFT22U_4XSkO5Ug</recordid><startdate>20100915</startdate><enddate>20100915</enddate><creator>Heath, Daniel E.</creator><creator>Cooper, Stuart L.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><scope>7QO</scope><scope>P64</scope></search><sort><creationdate>20100915</creationdate><title>Design and characterization of PEGylated terpolymer biomaterials</title><author>Heath, Daniel E. ; Cooper, Stuart L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4951-e999371c98dec83b2805633bc792821bf17070f6059e88528ef2f3151a46761e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adsorption - drug effects</topic><topic>Adult</topic><topic>Applied sciences</topic><topic>Biocompatible Materials - chemical synthesis</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Biological properties</topic><topic>Biomedical materials</topic><topic>blood compatible</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - ultrastructure</topic><topic>Cell Adhesion - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Cellular</topic><topic>Contact angle</topic><topic>Electrospinning</topic><topic>Endothelial Cells - cytology</topic><topic>Endothelial Cells - drug effects</topic><topic>Exact sciences and technology</topic><topic>Fibrinogen - metabolism</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methacrylates - chemical synthesis</topic><topic>Methacrylates - chemistry</topic><topic>Methacrylates - pharmacology</topic><topic>Methylmethacrylate - chemical synthesis</topic><topic>Methylmethacrylate - chemistry</topic><topic>Methylmethacrylate - pharmacology</topic><topic>Microscopy, Fluorescence</topic><topic>Molecular Weight</topic><topic>nonfouling</topic><topic>Organic polymers</topic><topic>Physicochemistry of polymers</topic><topic>Platelet Adhesiveness - drug effects</topic><topic>poly(ethylene glycol)</topic><topic>Polyethylene Glycols - chemical synthesis</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyethylene Glycols - pharmacology</topic><topic>Polymethyl methacrylates</topic><topic>Properties and characterization</topic><topic>Reproduction</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgical implants</topic><topic>Technology. Biomaterials. Equipments</topic><topic>terpolymer</topic><topic>Terpolymers</topic><topic>Umbilical Veins - cytology</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heath, Daniel E.</creatorcontrib><creatorcontrib>Cooper, Stuart L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of biomedical materials research. Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heath, Daniel E.</au><au>Cooper, Stuart L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Design and characterization of PEGylated terpolymer biomaterials</atitle><jtitle>Journal of biomedical materials research. Part A</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2010-09-15</date><risdate>2010</risdate><volume>94A</volume><issue>4</issue><spage>1294</spage><epage>1302</epage><pages>1294-1302</pages><issn>1549-3296</issn><issn>1552-4965</issn><eissn>1552-4965</eissn><abstract>A terpolymer copolymerized from hexyl methacrylate, methyl methacrylate, and poly(ethylene glycol) methacrylate (PEGMA) was synthesized. Polymers containing 0–25 mol % PEGMA were studied. As the mole fraction of PEGMA in the polymer chains increased, the material becomes more hydrophilic as observed by a decrease in the contact angle of water (81°–68°) and an increase in the equilibrium water absorption (0.7–237 wt %). Furthermore, the material shows nonfouling interfacial properties through resistance to protein adsorption and cellular attachment. A total of 1.2 μg/cm2 fibrinogen, 18,000 HUVECs/cm2, and 3,000,000 platelets/cm2 adsorbed or adhered on non‐PEGylated materials, whereas very low amounts of protein or cells were observed on materials containing ≥15 mol % PEGMA. Being thermoplastic, the polymer can be processed postsynthesis. To illustrate the processing capabilities of the material, polymer solutions were electrospun into nonwoven fibrous scaffold, which also retained their nonfouling character. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20694997</pmid><doi>10.1002/jbm.a.32811</doi><tpages>9</tpages></addata></record> |
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| subjects | Adsorption - drug effects Adult Applied sciences Biocompatible Materials - chemical synthesis Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biological and medical sciences Biological properties Biomedical materials blood compatible Blood Platelets - drug effects Blood Platelets - ultrastructure Cell Adhesion - drug effects Cell Proliferation - drug effects Cellular Contact angle Electrospinning Endothelial Cells - cytology Endothelial Cells - drug effects Exact sciences and technology Fibrinogen - metabolism Humans Magnetic Resonance Spectroscopy Male Medical sciences Methacrylates - chemical synthesis Methacrylates - chemistry Methacrylates - pharmacology Methylmethacrylate - chemical synthesis Methylmethacrylate - chemistry Methylmethacrylate - pharmacology Microscopy, Fluorescence Molecular Weight nonfouling Organic polymers Physicochemistry of polymers Platelet Adhesiveness - drug effects poly(ethylene glycol) Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology Polymethyl methacrylates Properties and characterization Reproduction Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical implants Technology. Biomaterials. Equipments terpolymer Terpolymers Umbilical Veins - cytology Water - chemistry |
| title | Design and characterization of PEGylated terpolymer biomaterials |
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