Usefulness of Double Vital Staining With 1% Fluorescein and 1% Lissamine Green in Patients With Dry Eye Syndrome
PURPOSE:To determine the relative staining characteristics of the nasal and temporal conjunctiva as compared with other measures of dry eye and evaluate the qualitative clinical impression of the utility of the double vital staining with fluorescein and lissamine green. METHODS:Ocular surface staini...
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| Veröffentlicht in: | Cornea 2011-09, Vol.30 (9), p.972-976 |
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| creator | Yoon, Kyung-Chul Im, Seong-Kyu Kim, Hwang-Gyun You, In-Cheon |
| description | PURPOSE:To determine the relative staining characteristics of the nasal and temporal conjunctiva as compared with other measures of dry eye and evaluate the qualitative clinical impression of the utility of the double vital staining with fluorescein and lissamine green.
METHODS:Ocular surface staining was performed with a mixture of 1% fluorescein and 1% lissamine green in 50 patients with dry eye (12 patients with Sjögren syndrome and 38 patients with non-Sjögren syndrome). Ocular surface disease index (OSDI), tear breakup time (BUT), and Schirmer test were evaluated. Digital photographs were taken after vital staining on the ocular surface, and the grade of staining in various areas was assessed. Correlation among the degrees of staining, OSDI, and ocular surface parameters was analyzed.
RESULTS:The nasal conjunctiva evidenced greater staining compared with the temporal conjunctiva and cornea (P = 0.04). Staining of the nasal conjunctiva showed significant correlation with OSDI (P < 0.01) and BUT (P = 0.03). Staining of the temporal conjunctiva correlated significantly with OSDI (P = 0.01), and staining of the cornea correlated with BUT (P = 0.02).
CONCLUSIONS:Double vital staining with 1% fluorescein and 1% lissamine green correlates with symptoms and some ocular surface parameters in patients with dry eye and helps to identify ocular surface changes easily. It may be a useful method for the diagnosis of dry eye and the assessment of the therapeutic effect in patients with dry eye syndrome. |
| doi_str_mv | 10.1097/ICO.0b013e31820687dd |
| format | Article |
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METHODS:Ocular surface staining was performed with a mixture of 1% fluorescein and 1% lissamine green in 50 patients with dry eye (12 patients with Sjögren syndrome and 38 patients with non-Sjögren syndrome). Ocular surface disease index (OSDI), tear breakup time (BUT), and Schirmer test were evaluated. Digital photographs were taken after vital staining on the ocular surface, and the grade of staining in various areas was assessed. Correlation among the degrees of staining, OSDI, and ocular surface parameters was analyzed.
RESULTS:The nasal conjunctiva evidenced greater staining compared with the temporal conjunctiva and cornea (P = 0.04). Staining of the nasal conjunctiva showed significant correlation with OSDI (P < 0.01) and BUT (P = 0.03). Staining of the temporal conjunctiva correlated significantly with OSDI (P = 0.01), and staining of the cornea correlated with BUT (P = 0.02).
CONCLUSIONS:Double vital staining with 1% fluorescein and 1% lissamine green correlates with symptoms and some ocular surface parameters in patients with dry eye and helps to identify ocular surface changes easily. It may be a useful method for the diagnosis of dry eye and the assessment of the therapeutic effect in patients with dry eye syndrome.</description><identifier>ISSN: 0277-3740</identifier><identifier>EISSN: 1536-4798</identifier><identifier>DOI: 10.1097/ICO.0b013e31820687dd</identifier><identifier>PMID: 21705877</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Aged ; Coloring Agents ; Conjunctiva - pathology ; Dry Eye Syndromes - classification ; Dry Eye Syndromes - diagnosis ; Female ; Fluorescein ; Humans ; Lissamine Green Dyes ; Male ; Middle Aged ; Staining and Labeling - methods ; Tears - chemistry</subject><ispartof>Cornea, 2011-09, Vol.30 (9), p.972-976</ispartof><rights>2011 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3515-f24d22037b15082560ce8eb4b6ac75e0b1846aaf90518b614def8b308e27e9c03</citedby><cites>FETCH-LOGICAL-c3515-f24d22037b15082560ce8eb4b6ac75e0b1846aaf90518b614def8b308e27e9c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21705877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoon, Kyung-Chul</creatorcontrib><creatorcontrib>Im, Seong-Kyu</creatorcontrib><creatorcontrib>Kim, Hwang-Gyun</creatorcontrib><creatorcontrib>You, In-Cheon</creatorcontrib><title>Usefulness of Double Vital Staining With 1% Fluorescein and 1% Lissamine Green in Patients With Dry Eye Syndrome</title><title>Cornea</title><addtitle>Cornea</addtitle><description>PURPOSE:To determine the relative staining characteristics of the nasal and temporal conjunctiva as compared with other measures of dry eye and evaluate the qualitative clinical impression of the utility of the double vital staining with fluorescein and lissamine green.
METHODS:Ocular surface staining was performed with a mixture of 1% fluorescein and 1% lissamine green in 50 patients with dry eye (12 patients with Sjögren syndrome and 38 patients with non-Sjögren syndrome). Ocular surface disease index (OSDI), tear breakup time (BUT), and Schirmer test were evaluated. Digital photographs were taken after vital staining on the ocular surface, and the grade of staining in various areas was assessed. Correlation among the degrees of staining, OSDI, and ocular surface parameters was analyzed.
RESULTS:The nasal conjunctiva evidenced greater staining compared with the temporal conjunctiva and cornea (P = 0.04). Staining of the nasal conjunctiva showed significant correlation with OSDI (P < 0.01) and BUT (P = 0.03). Staining of the temporal conjunctiva correlated significantly with OSDI (P = 0.01), and staining of the cornea correlated with BUT (P = 0.02).
CONCLUSIONS:Double vital staining with 1% fluorescein and 1% lissamine green correlates with symptoms and some ocular surface parameters in patients with dry eye and helps to identify ocular surface changes easily. It may be a useful method for the diagnosis of dry eye and the assessment of the therapeutic effect in patients with dry eye syndrome.</description><subject>Adult</subject><subject>Aged</subject><subject>Coloring Agents</subject><subject>Conjunctiva - pathology</subject><subject>Dry Eye Syndromes - classification</subject><subject>Dry Eye Syndromes - diagnosis</subject><subject>Female</subject><subject>Fluorescein</subject><subject>Humans</subject><subject>Lissamine Green Dyes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Staining and Labeling - methods</subject><subject>Tears - chemistry</subject><issn>0277-3740</issn><issn>1536-4798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUUtr3DAQFqWl2ab5B6XoUnJyOpKsxx7L5gkLCSRpjkKyx121sryVbML--3rZpIWehpn5HsM3hHxicMZgqb_erG7PwAMTKJjhoIxu2zdkwaRQVa2X5i1ZANe6ErqGI_KhlJ8AoLXi78kRZxqk0XpBto8FuykmLIUOHT0fJh-Rfg-ji_R-dCGF9IM-hXFD2Rd6GachY2kwJOpSux-tQymuDwnpVUZMdN7cuTFgGsuBdp539GKH9H6X2jz0-JG861wsePJSj8nj5cXD6rpa317drL6tq0ZIJquO1y3nILRnEgyXCho06GuvXKMlgmemVs51S5DMeMXqFjvjBRjkGpcNiGNyetDd5uH3hGW0fZgvj9ElHKZijRHAuBJmRtYHZJOHUjJ2dptD7_LOMrD7qO0ctf0_6pn2-cVg8j22f0mv2f7TfR7iiLn8itMzZrtBF8eNnZ8BgnNVcWCzydxV-5EUfwACZIlk</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Yoon, Kyung-Chul</creator><creator>Im, Seong-Kyu</creator><creator>Kim, Hwang-Gyun</creator><creator>You, In-Cheon</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201109</creationdate><title>Usefulness of Double Vital Staining With 1% Fluorescein and 1% Lissamine Green in Patients With Dry Eye Syndrome</title><author>Yoon, Kyung-Chul ; Im, Seong-Kyu ; Kim, Hwang-Gyun ; You, In-Cheon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3515-f24d22037b15082560ce8eb4b6ac75e0b1846aaf90518b614def8b308e27e9c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Coloring Agents</topic><topic>Conjunctiva - pathology</topic><topic>Dry Eye Syndromes - classification</topic><topic>Dry Eye Syndromes - diagnosis</topic><topic>Female</topic><topic>Fluorescein</topic><topic>Humans</topic><topic>Lissamine Green Dyes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Staining and Labeling - methods</topic><topic>Tears - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoon, Kyung-Chul</creatorcontrib><creatorcontrib>Im, Seong-Kyu</creatorcontrib><creatorcontrib>Kim, Hwang-Gyun</creatorcontrib><creatorcontrib>You, In-Cheon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cornea</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoon, Kyung-Chul</au><au>Im, Seong-Kyu</au><au>Kim, Hwang-Gyun</au><au>You, In-Cheon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Usefulness of Double Vital Staining With 1% Fluorescein and 1% Lissamine Green in Patients With Dry Eye Syndrome</atitle><jtitle>Cornea</jtitle><addtitle>Cornea</addtitle><date>2011-09</date><risdate>2011</risdate><volume>30</volume><issue>9</issue><spage>972</spage><epage>976</epage><pages>972-976</pages><issn>0277-3740</issn><eissn>1536-4798</eissn><abstract>PURPOSE:To determine the relative staining characteristics of the nasal and temporal conjunctiva as compared with other measures of dry eye and evaluate the qualitative clinical impression of the utility of the double vital staining with fluorescein and lissamine green.
METHODS:Ocular surface staining was performed with a mixture of 1% fluorescein and 1% lissamine green in 50 patients with dry eye (12 patients with Sjögren syndrome and 38 patients with non-Sjögren syndrome). Ocular surface disease index (OSDI), tear breakup time (BUT), and Schirmer test were evaluated. Digital photographs were taken after vital staining on the ocular surface, and the grade of staining in various areas was assessed. Correlation among the degrees of staining, OSDI, and ocular surface parameters was analyzed.
RESULTS:The nasal conjunctiva evidenced greater staining compared with the temporal conjunctiva and cornea (P = 0.04). Staining of the nasal conjunctiva showed significant correlation with OSDI (P < 0.01) and BUT (P = 0.03). Staining of the temporal conjunctiva correlated significantly with OSDI (P = 0.01), and staining of the cornea correlated with BUT (P = 0.02).
CONCLUSIONS:Double vital staining with 1% fluorescein and 1% lissamine green correlates with symptoms and some ocular surface parameters in patients with dry eye and helps to identify ocular surface changes easily. It may be a useful method for the diagnosis of dry eye and the assessment of the therapeutic effect in patients with dry eye syndrome.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>21705877</pmid><doi>10.1097/ICO.0b013e31820687dd</doi><tpages>5</tpages></addata></record> |
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| ispartof | Cornea, 2011-09, Vol.30 (9), p.972-976 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Coloring Agents Conjunctiva - pathology Dry Eye Syndromes - classification Dry Eye Syndromes - diagnosis Female Fluorescein Humans Lissamine Green Dyes Male Middle Aged Staining and Labeling - methods Tears - chemistry |
| title | Usefulness of Double Vital Staining With 1% Fluorescein and 1% Lissamine Green in Patients With Dry Eye Syndrome |
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