Chemical affinity matrix-based identification of prohibitin as a binding protein to anti-resorptive sulfonyl amidine compounds

In order to identify the binding proteins to anti-resorptive 5-chloro-1-(2,6-dimethylpiperidin-1-yl)- N-tosylpentan-1-imine ( 1), the chemical affinity matrix for the compound 1 ( 2b) was designed and synthesized. Using 2b-based chemical proteomics, prohibitin was identified as one of strong binding...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2011-01, Vol.21 (2), p.727-729
Hauptverfasser:	Chang, Sung-Youn, Bae, Su Jung, Lee, Myung Yun, Baek, Seung-hwa, Chang, Sukbok, Kim, Seong Hwan
Format:	Artikel
Sprache:	eng
Schlagworte:	amidines Amidines - chemistry Amidines - pharmacology Animals binding proteins Bone Density Conservation Agents - chemistry Bone Density Conservation Agents - pharmacology Cell Line Chemical affinity matrix Chemical proteomics Chromatography, Affinity - methods Mice Prohibitin Protein Binding proteomics Proteomics - methods Repressor Proteins - isolation & purification Repressor Proteins - metabolism Sulfinic Acids - chemistry Sulfinic Acids - pharmacology
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Zusammenfassung:	In order to identify the binding proteins to anti-resorptive 5-chloro-1-(2,6-dimethylpiperidin-1-yl)- N-tosylpentan-1-imine ( 1), the chemical affinity matrix for the compound 1 ( 2b) was designed and synthesized. Using 2b-based chemical proteomics, prohibitin was identified as one of strong binding proteins for 2b. In order to identify the binding proteins to anti-resorptive 5-chloro-1-(2,6-dimethylpiperidin-1-yl)- N-tosylpentan-1-imine ( 1), the chemical affinity matrix for the compound 1 ( 2b) was designed and synthesized. Using 2b-based chemical proteomics, prohibitin was identified as one of strong binding proteins for 2b.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2010.11.123