GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis
Objective The roles that amino acids play in immunity and inflammation are well defined, and the relationship between inflammatory bowel disease (IBD) and certain amino acids has recently attracted attention. In this study, the levels of amino acids and trichloroacetic acid (TCA) cycle-related molec...
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| Veröffentlicht in: | Inflammation research 2011-09, Vol.60 (9), p.831-840 |
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| creator | Ooi, Makoto Nishiumi, Shin Yoshie, Tomoo Shiomi, Yuuki Kohashi, Michitaka Fukunaga, Ken Nakamura, Shiro Matsumoto, Takayuki Hatano, Naoya Shinohara, Masakazu Irino, Yasuhiro Takenawa, Tadaomi Azuma, Takeshi Yoshida, Masaru |
| description | Objective
The roles that amino acids play in immunity and inflammation are well defined, and the relationship between inflammatory bowel disease (IBD) and certain amino acids has recently attracted attention. In this study, the levels of amino acids and trichloroacetic acid (TCA) cycle-related molecules in the colonic tissues and sera of patients with ulcerative colitis (UC) were profiled by gas chromatography/mass spectrometry (GC/MS), with the aim of evaluating whether the clinical state induced by UC leads to variations in the amino acid profile.
Materials and methods
Colonic biopsy samples from 22 UC patients were used, as well as serum samples from UC patients (
n
= 13), Crohn’s disease (CD) patients (
n
= 21), and healthy volunteers (
n
= 17).
Results
In the GC/MS-based profiling of amino acids and TCA cycle-related molecules, lower levels of 16 amino acids and 5 TCA cycle-related molecules were observed in the colonic lesion tissues of the UC patients, and the serum profiles of amino acids and TCA cycle-related molecules of the UC patients were different from those of the CD patients and healthy volunteers.
Conclusions
Our study raises the possibility that GC/MS-based profiling of amino acids and TCA cycle-related molecules is a useful early diagnostic tool for UC. |
| doi_str_mv | 10.1007/s00011-011-0340-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_883010455</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>883010455</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-db1d76f6a4ce34355d934226518c090e14e351fdafa75cc2accf18edabbe8a9c3</originalsourceid><addsrcrecordid>eNp90U1LHTEUBuAgFbXqD3AjgS7aTerJ1yR3KZdWCxYXKkg3QyY5I5HMjE1mCv77Rq8VKbSLkECec_LxEnLE4TMHMCcFADhnz0MqYGaL7HElgK3A3r6raxCSSSthl7wv5b5qK6zYIbuCayE12D3y42x98v2Kda5goA956mOK4x2deuqGOE7U-RgKdWOg1-tT6h99QpYxubnyYUrol4SFxpEuyWN2c_yF1E8pzrEckO3epYKHL_M-ufn65Xp9zi4uz76tTy-YVwZmFjoeTNM3TnmUSmodVlIJ0WhuPawAuUKpeR9c74z2Xjjve24xuK5D61Ze7pOPm771-j8XLHM7xOIxJTfitJTW1g_goLSu8tN_JVdcaN2Yhlf64S96Py15rO-oSlgDxsKT4hvl81RKxr59yHFw-bHl0D5F1G4iap9Hjag1teb4pfPSDRheK_5kUoHYgFK3xjvMb47-Z9ffHPKaeQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1428707801</pqid></control><display><type>article</type><title>GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Ooi, Makoto ; Nishiumi, Shin ; Yoshie, Tomoo ; Shiomi, Yuuki ; Kohashi, Michitaka ; Fukunaga, Ken ; Nakamura, Shiro ; Matsumoto, Takayuki ; Hatano, Naoya ; Shinohara, Masakazu ; Irino, Yasuhiro ; Takenawa, Tadaomi ; Azuma, Takeshi ; Yoshida, Masaru</creator><creatorcontrib>Ooi, Makoto ; Nishiumi, Shin ; Yoshie, Tomoo ; Shiomi, Yuuki ; Kohashi, Michitaka ; Fukunaga, Ken ; Nakamura, Shiro ; Matsumoto, Takayuki ; Hatano, Naoya ; Shinohara, Masakazu ; Irino, Yasuhiro ; Takenawa, Tadaomi ; Azuma, Takeshi ; Yoshida, Masaru</creatorcontrib><description>Objective
The roles that amino acids play in immunity and inflammation are well defined, and the relationship between inflammatory bowel disease (IBD) and certain amino acids has recently attracted attention. In this study, the levels of amino acids and trichloroacetic acid (TCA) cycle-related molecules in the colonic tissues and sera of patients with ulcerative colitis (UC) were profiled by gas chromatography/mass spectrometry (GC/MS), with the aim of evaluating whether the clinical state induced by UC leads to variations in the amino acid profile.
Materials and methods
Colonic biopsy samples from 22 UC patients were used, as well as serum samples from UC patients (
n
= 13), Crohn’s disease (CD) patients (
n
= 21), and healthy volunteers (
n
= 17).
Results
In the GC/MS-based profiling of amino acids and TCA cycle-related molecules, lower levels of 16 amino acids and 5 TCA cycle-related molecules were observed in the colonic lesion tissues of the UC patients, and the serum profiles of amino acids and TCA cycle-related molecules of the UC patients were different from those of the CD patients and healthy volunteers.
Conclusions
Our study raises the possibility that GC/MS-based profiling of amino acids and TCA cycle-related molecules is a useful early diagnostic tool for UC.</description><identifier>ISSN: 1023-3830</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/s00011-011-0340-7</identifier><identifier>PMID: 21523508</identifier><language>eng</language><publisher>Basel: SP Birkhäuser Verlag Basel</publisher><subject>Adult ; Allergology ; Amino Acids - chemistry ; Amino Acids - metabolism ; Biomarkers - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Citric Acid Cycle - physiology ; Colitis, Ulcerative - diagnosis ; Colitis, Ulcerative - metabolism ; Colitis, Ulcerative - pathology ; Colitis, Ulcerative - physiopathology ; Crohn Disease - diagnosis ; Crohn Disease - metabolism ; Crohn Disease - pathology ; Crohn Disease - physiopathology ; Dermatology ; Female ; Gas Chromatography-Mass Spectrometry - methods ; Humans ; Immunology ; Male ; Metabolomics - methods ; Middle Aged ; Neurology ; Original Research Paper ; Pharmacology/Toxicology ; Principal Component Analysis ; Rheumatology ; Young Adult</subject><ispartof>Inflammation research, 2011-09, Vol.60 (9), p.831-840</ispartof><rights>Springer Basel AG 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-db1d76f6a4ce34355d934226518c090e14e351fdafa75cc2accf18edabbe8a9c3</citedby><cites>FETCH-LOGICAL-c470t-db1d76f6a4ce34355d934226518c090e14e351fdafa75cc2accf18edabbe8a9c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00011-011-0340-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00011-011-0340-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21523508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ooi, Makoto</creatorcontrib><creatorcontrib>Nishiumi, Shin</creatorcontrib><creatorcontrib>Yoshie, Tomoo</creatorcontrib><creatorcontrib>Shiomi, Yuuki</creatorcontrib><creatorcontrib>Kohashi, Michitaka</creatorcontrib><creatorcontrib>Fukunaga, Ken</creatorcontrib><creatorcontrib>Nakamura, Shiro</creatorcontrib><creatorcontrib>Matsumoto, Takayuki</creatorcontrib><creatorcontrib>Hatano, Naoya</creatorcontrib><creatorcontrib>Shinohara, Masakazu</creatorcontrib><creatorcontrib>Irino, Yasuhiro</creatorcontrib><creatorcontrib>Takenawa, Tadaomi</creatorcontrib><creatorcontrib>Azuma, Takeshi</creatorcontrib><creatorcontrib>Yoshida, Masaru</creatorcontrib><title>GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis</title><title>Inflammation research</title><addtitle>Inflamm. Res</addtitle><addtitle>Inflamm Res</addtitle><description>Objective
The roles that amino acids play in immunity and inflammation are well defined, and the relationship between inflammatory bowel disease (IBD) and certain amino acids has recently attracted attention. In this study, the levels of amino acids and trichloroacetic acid (TCA) cycle-related molecules in the colonic tissues and sera of patients with ulcerative colitis (UC) were profiled by gas chromatography/mass spectrometry (GC/MS), with the aim of evaluating whether the clinical state induced by UC leads to variations in the amino acid profile.
Materials and methods
Colonic biopsy samples from 22 UC patients were used, as well as serum samples from UC patients (
n
= 13), Crohn’s disease (CD) patients (
n
= 21), and healthy volunteers (
n
= 17).
Results
In the GC/MS-based profiling of amino acids and TCA cycle-related molecules, lower levels of 16 amino acids and 5 TCA cycle-related molecules were observed in the colonic lesion tissues of the UC patients, and the serum profiles of amino acids and TCA cycle-related molecules of the UC patients were different from those of the CD patients and healthy volunteers.
Conclusions
Our study raises the possibility that GC/MS-based profiling of amino acids and TCA cycle-related molecules is a useful early diagnostic tool for UC.</description><subject>Adult</subject><subject>Allergology</subject><subject>Amino Acids - chemistry</subject><subject>Amino Acids - metabolism</subject><subject>Biomarkers - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Citric Acid Cycle - physiology</subject><subject>Colitis, Ulcerative - diagnosis</subject><subject>Colitis, Ulcerative - metabolism</subject><subject>Colitis, Ulcerative - pathology</subject><subject>Colitis, Ulcerative - physiopathology</subject><subject>Crohn Disease - diagnosis</subject><subject>Crohn Disease - metabolism</subject><subject>Crohn Disease - pathology</subject><subject>Crohn Disease - physiopathology</subject><subject>Dermatology</subject><subject>Female</subject><subject>Gas Chromatography-Mass Spectrometry - methods</subject><subject>Humans</subject><subject>Immunology</subject><subject>Male</subject><subject>Metabolomics - methods</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Original Research Paper</subject><subject>Pharmacology/Toxicology</subject><subject>Principal Component Analysis</subject><subject>Rheumatology</subject><subject>Young Adult</subject><issn>1023-3830</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp90U1LHTEUBuAgFbXqD3AjgS7aTerJ1yR3KZdWCxYXKkg3QyY5I5HMjE1mCv77Rq8VKbSLkECec_LxEnLE4TMHMCcFADhnz0MqYGaL7HElgK3A3r6raxCSSSthl7wv5b5qK6zYIbuCayE12D3y42x98v2Kda5goA956mOK4x2deuqGOE7U-RgKdWOg1-tT6h99QpYxubnyYUrol4SFxpEuyWN2c_yF1E8pzrEckO3epYKHL_M-ufn65Xp9zi4uz76tTy-YVwZmFjoeTNM3TnmUSmodVlIJ0WhuPawAuUKpeR9c74z2Xjjve24xuK5D61Ze7pOPm771-j8XLHM7xOIxJTfitJTW1g_goLSu8tN_JVdcaN2Yhlf64S96Py15rO-oSlgDxsKT4hvl81RKxr59yHFw-bHl0D5F1G4iap9Hjag1teb4pfPSDRheK_5kUoHYgFK3xjvMb47-Z9ffHPKaeQ</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Ooi, Makoto</creator><creator>Nishiumi, Shin</creator><creator>Yoshie, Tomoo</creator><creator>Shiomi, Yuuki</creator><creator>Kohashi, Michitaka</creator><creator>Fukunaga, Ken</creator><creator>Nakamura, Shiro</creator><creator>Matsumoto, Takayuki</creator><creator>Hatano, Naoya</creator><creator>Shinohara, Masakazu</creator><creator>Irino, Yasuhiro</creator><creator>Takenawa, Tadaomi</creator><creator>Azuma, Takeshi</creator><creator>Yoshida, Masaru</creator><general>SP Birkhäuser Verlag Basel</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis</title><author>Ooi, Makoto ; Nishiumi, Shin ; Yoshie, Tomoo ; Shiomi, Yuuki ; Kohashi, Michitaka ; Fukunaga, Ken ; Nakamura, Shiro ; Matsumoto, Takayuki ; Hatano, Naoya ; Shinohara, Masakazu ; Irino, Yasuhiro ; Takenawa, Tadaomi ; Azuma, Takeshi ; Yoshida, Masaru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-db1d76f6a4ce34355d934226518c090e14e351fdafa75cc2accf18edabbe8a9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Allergology</topic><topic>Amino Acids - chemistry</topic><topic>Amino Acids - metabolism</topic><topic>Biomarkers - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Citric Acid Cycle - physiology</topic><topic>Colitis, Ulcerative - diagnosis</topic><topic>Colitis, Ulcerative - metabolism</topic><topic>Colitis, Ulcerative - pathology</topic><topic>Colitis, Ulcerative - physiopathology</topic><topic>Crohn Disease - diagnosis</topic><topic>Crohn Disease - metabolism</topic><topic>Crohn Disease - pathology</topic><topic>Crohn Disease - physiopathology</topic><topic>Dermatology</topic><topic>Female</topic><topic>Gas Chromatography-Mass Spectrometry - methods</topic><topic>Humans</topic><topic>Immunology</topic><topic>Male</topic><topic>Metabolomics - methods</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Original Research Paper</topic><topic>Pharmacology/Toxicology</topic><topic>Principal Component Analysis</topic><topic>Rheumatology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ooi, Makoto</creatorcontrib><creatorcontrib>Nishiumi, Shin</creatorcontrib><creatorcontrib>Yoshie, Tomoo</creatorcontrib><creatorcontrib>Shiomi, Yuuki</creatorcontrib><creatorcontrib>Kohashi, Michitaka</creatorcontrib><creatorcontrib>Fukunaga, Ken</creatorcontrib><creatorcontrib>Nakamura, Shiro</creatorcontrib><creatorcontrib>Matsumoto, Takayuki</creatorcontrib><creatorcontrib>Hatano, Naoya</creatorcontrib><creatorcontrib>Shinohara, Masakazu</creatorcontrib><creatorcontrib>Irino, Yasuhiro</creatorcontrib><creatorcontrib>Takenawa, Tadaomi</creatorcontrib><creatorcontrib>Azuma, Takeshi</creatorcontrib><creatorcontrib>Yoshida, Masaru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ooi, Makoto</au><au>Nishiumi, Shin</au><au>Yoshie, Tomoo</au><au>Shiomi, Yuuki</au><au>Kohashi, Michitaka</au><au>Fukunaga, Ken</au><au>Nakamura, Shiro</au><au>Matsumoto, Takayuki</au><au>Hatano, Naoya</au><au>Shinohara, Masakazu</au><au>Irino, Yasuhiro</au><au>Takenawa, Tadaomi</au><au>Azuma, Takeshi</au><au>Yoshida, Masaru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis</atitle><jtitle>Inflammation research</jtitle><stitle>Inflamm. Res</stitle><addtitle>Inflamm Res</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>60</volume><issue>9</issue><spage>831</spage><epage>840</epage><pages>831-840</pages><issn>1023-3830</issn><eissn>1420-908X</eissn><abstract>Objective
The roles that amino acids play in immunity and inflammation are well defined, and the relationship between inflammatory bowel disease (IBD) and certain amino acids has recently attracted attention. In this study, the levels of amino acids and trichloroacetic acid (TCA) cycle-related molecules in the colonic tissues and sera of patients with ulcerative colitis (UC) were profiled by gas chromatography/mass spectrometry (GC/MS), with the aim of evaluating whether the clinical state induced by UC leads to variations in the amino acid profile.
Materials and methods
Colonic biopsy samples from 22 UC patients were used, as well as serum samples from UC patients (
n
= 13), Crohn’s disease (CD) patients (
n
= 21), and healthy volunteers (
n
= 17).
Results
In the GC/MS-based profiling of amino acids and TCA cycle-related molecules, lower levels of 16 amino acids and 5 TCA cycle-related molecules were observed in the colonic lesion tissues of the UC patients, and the serum profiles of amino acids and TCA cycle-related molecules of the UC patients were different from those of the CD patients and healthy volunteers.
Conclusions
Our study raises the possibility that GC/MS-based profiling of amino acids and TCA cycle-related molecules is a useful early diagnostic tool for UC.</abstract><cop>Basel</cop><pub>SP Birkhäuser Verlag Basel</pub><pmid>21523508</pmid><doi>10.1007/s00011-011-0340-7</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 1023-3830 |
| ispartof | Inflammation research, 2011-09, Vol.60 (9), p.831-840 |
| issn | 1023-3830 1420-908X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_883010455 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Allergology Amino Acids - chemistry Amino Acids - metabolism Biomarkers - metabolism Biomedical and Life Sciences Biomedicine Citric Acid Cycle - physiology Colitis, Ulcerative - diagnosis Colitis, Ulcerative - metabolism Colitis, Ulcerative - pathology Colitis, Ulcerative - physiopathology Crohn Disease - diagnosis Crohn Disease - metabolism Crohn Disease - pathology Crohn Disease - physiopathology Dermatology Female Gas Chromatography-Mass Spectrometry - methods Humans Immunology Male Metabolomics - methods Middle Aged Neurology Original Research Paper Pharmacology/Toxicology Principal Component Analysis Rheumatology Young Adult |
| title | GC/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis |
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