Efficacy of dinoprostone and misoprostol for labor induction in nulliparous women
to determine the efficacy and safety of dinoprostone and misoprostol for the induction of vaginal childbirth, with or without the use of oxytocin in nulliparous women. in this retrospective observational study, 238 patients were subjected to the induction of delivery from January 2008 to February 20...
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| Veröffentlicht in: | Revista Brasileira de ginecologia e obstetrícia 2011-03, Vol.33 (3), p.118-122 |
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| container_title | Revista Brasileira de ginecologia e obstetrícia |
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| creator | Oliveira, Tenilson Amaral Melo, Elisa Matias Vieira de Aquino, Márcia Maria Auxiliadora de Mariani Neto, Corintio |
| description | to determine the efficacy and safety of dinoprostone and misoprostol for the induction of vaginal childbirth, with or without the use of oxytocin in nulliparous women.
in this retrospective observational study, 238 patients were subjected to the induction of delivery from January 2008 to February 2010 with the use of misoprostol 25 mcg by the vaginal route or a pessary containing 10 mg of dinoprostone. A total of 184 patients were selected, with the following characteristics: nulliparous, gestational age of 37-42 weeks, singleton pregnancies, cephalic presentation, intact membranes, and Bishop score < 3. Obstetric and neonatal data were analyzed and compared between groups. The Student t-test, chi-square test and Fisher's exact test were used for statistical analysis, with the level of significance set at p |
| format | Article |
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in this retrospective observational study, 238 patients were subjected to the induction of delivery from January 2008 to February 2010 with the use of misoprostol 25 mcg by the vaginal route or a pessary containing 10 mg of dinoprostone. A total of 184 patients were selected, with the following characteristics: nulliparous, gestational age of 37-42 weeks, singleton pregnancies, cephalic presentation, intact membranes, and Bishop score < 3. Obstetric and neonatal data were analyzed and compared between groups. The Student t-test, chi-square test and Fisher's exact test were used for statistical analysis, with the level of significance set at p<0.05.
the rate of vaginal childbirth did not differ significantly in patients who used misoprostol and dinoprostone (43.2% versus 50%; p = 0.35, respectively). The ripening of cervix was higher in the group treated with misoprostol (87.3% versus 75.6%, p=0.04). The use of oxytocin was necessary in 58.8% of the misoprostol group and 57.3% in the dinoprostone group after the ripening of cervix. Failed induction was the primary indication of caesarean section delivery in both groups, with no significant difference between them. Fetal and maternal adverse events, such as tachysystole and Apgar scores were similar.
dinoprostone and misoprostol are both effective for vaginal childbirth induction, although they need to be combined with oxytocin. They showed a similar safety profile, with misoprostol being more efficient regarding cervical ripening.</description><identifier>EISSN: 1806-9339</identifier><identifier>PMID: 21829994</identifier><language>por</language><publisher>Brazil</publisher><subject>Dinoprostone - therapeutic use ; Female ; Humans ; Labor, Induced ; Misoprostol - therapeutic use ; Oxytocics - therapeutic use ; Parity ; Pregnancy ; Retrospective Studies ; Young Adult</subject><ispartof>Revista Brasileira de ginecologia e obstetrícia, 2011-03, Vol.33 (3), p.118-122</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21829994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oliveira, Tenilson Amaral</creatorcontrib><creatorcontrib>Melo, Elisa Matias Vieira de</creatorcontrib><creatorcontrib>Aquino, Márcia Maria Auxiliadora de</creatorcontrib><creatorcontrib>Mariani Neto, Corintio</creatorcontrib><title>Efficacy of dinoprostone and misoprostol for labor induction in nulliparous women</title><title>Revista Brasileira de ginecologia e obstetrícia</title><addtitle>Rev Bras Ginecol Obstet</addtitle><description>to determine the efficacy and safety of dinoprostone and misoprostol for the induction of vaginal childbirth, with or without the use of oxytocin in nulliparous women.
in this retrospective observational study, 238 patients were subjected to the induction of delivery from January 2008 to February 2010 with the use of misoprostol 25 mcg by the vaginal route or a pessary containing 10 mg of dinoprostone. A total of 184 patients were selected, with the following characteristics: nulliparous, gestational age of 37-42 weeks, singleton pregnancies, cephalic presentation, intact membranes, and Bishop score < 3. Obstetric and neonatal data were analyzed and compared between groups. The Student t-test, chi-square test and Fisher's exact test were used for statistical analysis, with the level of significance set at p<0.05.
the rate of vaginal childbirth did not differ significantly in patients who used misoprostol and dinoprostone (43.2% versus 50%; p = 0.35, respectively). The ripening of cervix was higher in the group treated with misoprostol (87.3% versus 75.6%, p=0.04). The use of oxytocin was necessary in 58.8% of the misoprostol group and 57.3% in the dinoprostone group after the ripening of cervix. Failed induction was the primary indication of caesarean section delivery in both groups, with no significant difference between them. Fetal and maternal adverse events, such as tachysystole and Apgar scores were similar.
dinoprostone and misoprostol are both effective for vaginal childbirth induction, although they need to be combined with oxytocin. They showed a similar safety profile, with misoprostol being more efficient regarding cervical ripening.</description><subject>Dinoprostone - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Labor, Induced</subject><subject>Misoprostol - therapeutic use</subject><subject>Oxytocics - therapeutic use</subject><subject>Parity</subject><subject>Pregnancy</subject><subject>Retrospective Studies</subject><subject>Young Adult</subject><issn>1806-9339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtqwzAQRUWhJGmaXyjadWXQw5alZQnpAwKh0K6NLI1ARZZcy6bk7yuou7kzDIfhcG_QjkoiKsW52qK7nL8IYS2X9QZtGZVMKVXv0PvJOW-0ueLksPUxjVPKc4qAdbR48Hk9BOzShIPuS_poFzP7FMuG4xKCH_WUlox_0gDxHt06HTIc1rlHn8-nj-Nrdb68vB2fztVIazJX0KtGKFqDNEY2ICUowVXbcgCinXGM0F4bLQSlvYIaLIGWO8E1cc5y0fA9evz7WwS_F8hzV2wNhKAjFJlOSk6IZIwW8mEll34A242TH_R07f5b4L-amFmq</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Oliveira, Tenilson Amaral</creator><creator>Melo, Elisa Matias Vieira de</creator><creator>Aquino, Márcia Maria Auxiliadora de</creator><creator>Mariani Neto, Corintio</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201103</creationdate><title>Efficacy of dinoprostone and misoprostol for labor induction in nulliparous women</title><author>Oliveira, Tenilson Amaral ; Melo, Elisa Matias Vieira de ; Aquino, Márcia Maria Auxiliadora de ; Mariani Neto, Corintio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p140t-eb956914e8cc85e88e9639773ee0afcf201baca6611b9e4ed0e73f63a0ffd3653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>por</language><creationdate>2011</creationdate><topic>Dinoprostone - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Labor, Induced</topic><topic>Misoprostol - therapeutic use</topic><topic>Oxytocics - therapeutic use</topic><topic>Parity</topic><topic>Pregnancy</topic><topic>Retrospective Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oliveira, Tenilson Amaral</creatorcontrib><creatorcontrib>Melo, Elisa Matias Vieira de</creatorcontrib><creatorcontrib>Aquino, Márcia Maria Auxiliadora de</creatorcontrib><creatorcontrib>Mariani Neto, Corintio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Revista Brasileira de ginecologia e obstetrícia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oliveira, Tenilson Amaral</au><au>Melo, Elisa Matias Vieira de</au><au>Aquino, Márcia Maria Auxiliadora de</au><au>Mariani Neto, Corintio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of dinoprostone and misoprostol for labor induction in nulliparous women</atitle><jtitle>Revista Brasileira de ginecologia e obstetrícia</jtitle><addtitle>Rev Bras Ginecol Obstet</addtitle><date>2011-03</date><risdate>2011</risdate><volume>33</volume><issue>3</issue><spage>118</spage><epage>122</epage><pages>118-122</pages><eissn>1806-9339</eissn><abstract>to determine the efficacy and safety of dinoprostone and misoprostol for the induction of vaginal childbirth, with or without the use of oxytocin in nulliparous women.
in this retrospective observational study, 238 patients were subjected to the induction of delivery from January 2008 to February 2010 with the use of misoprostol 25 mcg by the vaginal route or a pessary containing 10 mg of dinoprostone. A total of 184 patients were selected, with the following characteristics: nulliparous, gestational age of 37-42 weeks, singleton pregnancies, cephalic presentation, intact membranes, and Bishop score < 3. Obstetric and neonatal data were analyzed and compared between groups. The Student t-test, chi-square test and Fisher's exact test were used for statistical analysis, with the level of significance set at p<0.05.
the rate of vaginal childbirth did not differ significantly in patients who used misoprostol and dinoprostone (43.2% versus 50%; p = 0.35, respectively). The ripening of cervix was higher in the group treated with misoprostol (87.3% versus 75.6%, p=0.04). The use of oxytocin was necessary in 58.8% of the misoprostol group and 57.3% in the dinoprostone group after the ripening of cervix. Failed induction was the primary indication of caesarean section delivery in both groups, with no significant difference between them. Fetal and maternal adverse events, such as tachysystole and Apgar scores were similar.
dinoprostone and misoprostol are both effective for vaginal childbirth induction, although they need to be combined with oxytocin. They showed a similar safety profile, with misoprostol being more efficient regarding cervical ripening.</abstract><cop>Brazil</cop><pmid>21829994</pmid><tpages>5</tpages></addata></record> |
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| identifier | EISSN: 1806-9339 |
| ispartof | Revista Brasileira de ginecologia e obstetrícia, 2011-03, Vol.33 (3), p.118-122 |
| issn | 1806-9339 |
| language | por |
| recordid | cdi_proquest_miscellaneous_883008221 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Dinoprostone - therapeutic use Female Humans Labor, Induced Misoprostol - therapeutic use Oxytocics - therapeutic use Parity Pregnancy Retrospective Studies Young Adult |
| title | Efficacy of dinoprostone and misoprostol for labor induction in nulliparous women |
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