Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L. (Lamiaceae)
Objectives The purpose of this study was to assess the gastroprotective properties of the methanol extract and the diterpene marrubiin obtained from the leaves of M. vulgare. Methods Assays were performed using different protocols in mice. Studies focusing on mechanisms of gastroprotection were al...
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| Veröffentlicht in: | Journal of pharmacy and pharmacology 2011-09, Vol.63 (9), p.1230-1237 |
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| creator | Paula de Oliveira, Ana Santin, José Roberto Lemos, Marivane Klein Júnior, Luiz Carlos Couto, Angélica Garcia Meyre da Silva Bittencourt, Christiane Filho, Valdir Cechinel Faloni de Andrade, Sérgio |
| description | Objectives The purpose of this study was to assess the gastroprotective properties of the methanol extract and the diterpene marrubiin obtained from the leaves of M. vulgare.
Methods Assays were performed using different protocols in mice. Studies focusing on mechanisms of gastroprotection were also undertaken.
Key findings In the model of ethanol‐induced ulcers, we observed a significant reduction in all the parameters analysed; the curative ratios obtained were 49.31 ± 0.57, 74.31 ± 0.91 and 79.86 ± 0.59 for the groups treated with 50 and 100 mg/kg of extract of M. vulgare and omeprazole (30 mg/kg), respectively. For indomethacin‐induced ulcers, the percentages of ulcer inhibition were 50.32 ± 5.60, 66.24 ± 4.30, 82.17 ± 04.09 and 67.52 ± 4.38, for the groups treated with 25, 50 and 100 mg/kg M. vulgare and positive control (cimetidine), respectively. In both models, the marrubiin (25 mg/kg) produced a significant reduction in all the parameters when compared with the control group (P |
| doi_str_mv | 10.1111/j.2042-7158.2011.01321.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_883007226</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>883007226</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4571-99f0cd38d28dd5b788e70d7722b09dce2a3a43ff6d7941855135af97364348853</originalsourceid><addsrcrecordid>eNqNkMuO1DAQRS0EYpqBX0DeAYsEP-LY2SChEfSAAvQCNOwsJ66AmzxmbKfp_nscMvSa2lRJde8t1UEIU5LTVK_3OSMFyyQVKk2U5oRyRvPjA7Q5Lx6iDSGMZVxIfoGehLAnhMiyLB-jC0YVk0VVblDcmhD9dOunCG10B8BmaS6e8NThAeJPM049hmP0aYHNaPFgvJ8b50Y8NdG4ESzu_DTgHswBwmL7tCrmAR_m_ofxgOscv6zN4EwLBl49RY860wd4dt8v0bf3775eXWf1l-2Hq7d11hZC0qyqOtJarixT1opGKgWSWCkZa0hlW2CGm4J3XWllVVAlBOXCdJXkZcELpQS_RC_W3PTe3Qwh6sGFFvrejDDNQSvFExLGyqRUq7L1UwgeOn3rXXr0pCnRC3K91wtZvZDVC3L9F7k-Juvz-yNzM4A9G_8xToI3q-C36-H038H64-56t4wpIFsDXIhwPAcY_0uXkkuhbz5vdV2r7U39vdA7_gfRD5-M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>883007226</pqid></control><display><type>article</type><title>Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L. (Lamiaceae)</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Wiley Online Library All Journals</source><creator>Paula de Oliveira, Ana ; Santin, José Roberto ; Lemos, Marivane ; Klein Júnior, Luiz Carlos ; Couto, Angélica Garcia ; Meyre da Silva Bittencourt, Christiane ; Filho, Valdir Cechinel ; Faloni de Andrade, Sérgio</creator><creatorcontrib>Paula de Oliveira, Ana ; Santin, José Roberto ; Lemos, Marivane ; Klein Júnior, Luiz Carlos ; Couto, Angélica Garcia ; Meyre da Silva Bittencourt, Christiane ; Filho, Valdir Cechinel ; Faloni de Andrade, Sérgio</creatorcontrib><description>Objectives The purpose of this study was to assess the gastroprotective properties of the methanol extract and the diterpene marrubiin obtained from the leaves of M. vulgare.
Methods Assays were performed using different protocols in mice. Studies focusing on mechanisms of gastroprotection were also undertaken.
Key findings In the model of ethanol‐induced ulcers, we observed a significant reduction in all the parameters analysed; the curative ratios obtained were 49.31 ± 0.57, 74.31 ± 0.91 and 79.86 ± 0.59 for the groups treated with 50 and 100 mg/kg of extract of M. vulgare and omeprazole (30 mg/kg), respectively. For indomethacin‐induced ulcers, the percentages of ulcer inhibition were 50.32 ± 5.60, 66.24 ± 4.30, 82.17 ± 04.09 and 67.52 ± 4.38, for the groups treated with 25, 50 and 100 mg/kg M. vulgare and positive control (cimetidine), respectively. In both models, the marrubiin (25 mg/kg) produced a significant reduction in all the parameters when compared with the control group (P < 0.01). There was also a significant increase in pH and mucus production in the groups treated with M. vulgare extract and marubiin. The results also demonstrated that the gastroprotection induced by the extract and marubiin is related to the activity of nitric oxide and endogenous sulfhydryls, which are important gastroprotective factors.
Conclusions The results of this study show that the extract of M. vulgare and marrubiin displays antiulcer activity and that this effect can be partly attributed to the isolated diterpene.</description><identifier>ISSN: 0022-3573</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1111/j.2042-7158.2011.01321.x</identifier><identifier>PMID: 21827496</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Anti-Ulcer Agents - isolation & purification ; Anti-Ulcer Agents - pharmacology ; Anti-Ulcer Agents - therapeutic use ; antiulcerogenic activity ; Disease Models, Animal ; diterpene ; Diterpenes - isolation & purification ; Diterpenes - pharmacology ; Diterpenes - therapeutic use ; Ethanol ; Gastric Acid - secretion ; gastroprotection ; Hydrogen-Ion Concentration ; Indomethacin ; marrubiin ; Marrubium - chemistry ; Marrubium vulgare ; Mice ; Mucus - metabolism ; Nitric Oxide - metabolism ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Leaves ; Stomach Ulcer - chemically induced ; Stomach Ulcer - drug therapy</subject><ispartof>Journal of pharmacy and pharmacology, 2011-09, Vol.63 (9), p.1230-1237</ispartof><rights>2011 The Authors. JPP © 2011 Royal Pharmaceutical Society</rights><rights>2011 The Authors. JPP © 2011 Royal Pharmaceutical Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4571-99f0cd38d28dd5b788e70d7722b09dce2a3a43ff6d7941855135af97364348853</citedby><cites>FETCH-LOGICAL-c4571-99f0cd38d28dd5b788e70d7722b09dce2a3a43ff6d7941855135af97364348853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.2042-7158.2011.01321.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.2042-7158.2011.01321.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21827496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paula de Oliveira, Ana</creatorcontrib><creatorcontrib>Santin, José Roberto</creatorcontrib><creatorcontrib>Lemos, Marivane</creatorcontrib><creatorcontrib>Klein Júnior, Luiz Carlos</creatorcontrib><creatorcontrib>Couto, Angélica Garcia</creatorcontrib><creatorcontrib>Meyre da Silva Bittencourt, Christiane</creatorcontrib><creatorcontrib>Filho, Valdir Cechinel</creatorcontrib><creatorcontrib>Faloni de Andrade, Sérgio</creatorcontrib><title>Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L. (Lamiaceae)</title><title>Journal of pharmacy and pharmacology</title><addtitle>J Pharm Pharmacol</addtitle><description>Objectives The purpose of this study was to assess the gastroprotective properties of the methanol extract and the diterpene marrubiin obtained from the leaves of M. vulgare.
Methods Assays were performed using different protocols in mice. Studies focusing on mechanisms of gastroprotection were also undertaken.
Key findings In the model of ethanol‐induced ulcers, we observed a significant reduction in all the parameters analysed; the curative ratios obtained were 49.31 ± 0.57, 74.31 ± 0.91 and 79.86 ± 0.59 for the groups treated with 50 and 100 mg/kg of extract of M. vulgare and omeprazole (30 mg/kg), respectively. For indomethacin‐induced ulcers, the percentages of ulcer inhibition were 50.32 ± 5.60, 66.24 ± 4.30, 82.17 ± 04.09 and 67.52 ± 4.38, for the groups treated with 25, 50 and 100 mg/kg M. vulgare and positive control (cimetidine), respectively. In both models, the marrubiin (25 mg/kg) produced a significant reduction in all the parameters when compared with the control group (P < 0.01). There was also a significant increase in pH and mucus production in the groups treated with M. vulgare extract and marubiin. The results also demonstrated that the gastroprotection induced by the extract and marubiin is related to the activity of nitric oxide and endogenous sulfhydryls, which are important gastroprotective factors.
Conclusions The results of this study show that the extract of M. vulgare and marrubiin displays antiulcer activity and that this effect can be partly attributed to the isolated diterpene.</description><subject>Animals</subject><subject>Anti-Ulcer Agents - isolation & purification</subject><subject>Anti-Ulcer Agents - pharmacology</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>antiulcerogenic activity</subject><subject>Disease Models, Animal</subject><subject>diterpene</subject><subject>Diterpenes - isolation & purification</subject><subject>Diterpenes - pharmacology</subject><subject>Diterpenes - therapeutic use</subject><subject>Ethanol</subject><subject>Gastric Acid - secretion</subject><subject>gastroprotection</subject><subject>Hydrogen-Ion Concentration</subject><subject>Indomethacin</subject><subject>marrubiin</subject><subject>Marrubium - chemistry</subject><subject>Marrubium vulgare</subject><subject>Mice</subject><subject>Mucus - metabolism</subject><subject>Nitric Oxide - metabolism</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Leaves</subject><subject>Stomach Ulcer - chemically induced</subject><subject>Stomach Ulcer - drug therapy</subject><issn>0022-3573</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMuO1DAQRS0EYpqBX0DeAYsEP-LY2SChEfSAAvQCNOwsJ66AmzxmbKfp_nscMvSa2lRJde8t1UEIU5LTVK_3OSMFyyQVKk2U5oRyRvPjA7Q5Lx6iDSGMZVxIfoGehLAnhMiyLB-jC0YVk0VVblDcmhD9dOunCG10B8BmaS6e8NThAeJPM049hmP0aYHNaPFgvJ8b50Y8NdG4ESzu_DTgHswBwmL7tCrmAR_m_ofxgOscv6zN4EwLBl49RY860wd4dt8v0bf3775eXWf1l-2Hq7d11hZC0qyqOtJarixT1opGKgWSWCkZa0hlW2CGm4J3XWllVVAlBOXCdJXkZcELpQS_RC_W3PTe3Qwh6sGFFvrejDDNQSvFExLGyqRUq7L1UwgeOn3rXXr0pCnRC3K91wtZvZDVC3L9F7k-Juvz-yNzM4A9G_8xToI3q-C36-H038H64-56t4wpIFsDXIhwPAcY_0uXkkuhbz5vdV2r7U39vdA7_gfRD5-M</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Paula de Oliveira, Ana</creator><creator>Santin, José Roberto</creator><creator>Lemos, Marivane</creator><creator>Klein Júnior, Luiz Carlos</creator><creator>Couto, Angélica Garcia</creator><creator>Meyre da Silva Bittencourt, Christiane</creator><creator>Filho, Valdir Cechinel</creator><creator>Faloni de Andrade, Sérgio</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201109</creationdate><title>Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L. (Lamiaceae)</title><author>Paula de Oliveira, Ana ; Santin, José Roberto ; Lemos, Marivane ; Klein Júnior, Luiz Carlos ; Couto, Angélica Garcia ; Meyre da Silva Bittencourt, Christiane ; Filho, Valdir Cechinel ; Faloni de Andrade, Sérgio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4571-99f0cd38d28dd5b788e70d7722b09dce2a3a43ff6d7941855135af97364348853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Anti-Ulcer Agents - isolation & purification</topic><topic>Anti-Ulcer Agents - pharmacology</topic><topic>Anti-Ulcer Agents - therapeutic use</topic><topic>antiulcerogenic activity</topic><topic>Disease Models, Animal</topic><topic>diterpene</topic><topic>Diterpenes - isolation & purification</topic><topic>Diterpenes - pharmacology</topic><topic>Diterpenes - therapeutic use</topic><topic>Ethanol</topic><topic>Gastric Acid - secretion</topic><topic>gastroprotection</topic><topic>Hydrogen-Ion Concentration</topic><topic>Indomethacin</topic><topic>marrubiin</topic><topic>Marrubium - chemistry</topic><topic>Marrubium vulgare</topic><topic>Mice</topic><topic>Mucus - metabolism</topic><topic>Nitric Oxide - metabolism</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Leaves</topic><topic>Stomach Ulcer - chemically induced</topic><topic>Stomach Ulcer - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paula de Oliveira, Ana</creatorcontrib><creatorcontrib>Santin, José Roberto</creatorcontrib><creatorcontrib>Lemos, Marivane</creatorcontrib><creatorcontrib>Klein Júnior, Luiz Carlos</creatorcontrib><creatorcontrib>Couto, Angélica Garcia</creatorcontrib><creatorcontrib>Meyre da Silva Bittencourt, Christiane</creatorcontrib><creatorcontrib>Filho, Valdir Cechinel</creatorcontrib><creatorcontrib>Faloni de Andrade, Sérgio</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmacy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paula de Oliveira, Ana</au><au>Santin, José Roberto</au><au>Lemos, Marivane</au><au>Klein Júnior, Luiz Carlos</au><au>Couto, Angélica Garcia</au><au>Meyre da Silva Bittencourt, Christiane</au><au>Filho, Valdir Cechinel</au><au>Faloni de Andrade, Sérgio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L. (Lamiaceae)</atitle><jtitle>Journal of pharmacy and pharmacology</jtitle><addtitle>J Pharm Pharmacol</addtitle><date>2011-09</date><risdate>2011</risdate><volume>63</volume><issue>9</issue><spage>1230</spage><epage>1237</epage><pages>1230-1237</pages><issn>0022-3573</issn><eissn>2042-7158</eissn><abstract>Objectives The purpose of this study was to assess the gastroprotective properties of the methanol extract and the diterpene marrubiin obtained from the leaves of M. vulgare.
Methods Assays were performed using different protocols in mice. Studies focusing on mechanisms of gastroprotection were also undertaken.
Key findings In the model of ethanol‐induced ulcers, we observed a significant reduction in all the parameters analysed; the curative ratios obtained were 49.31 ± 0.57, 74.31 ± 0.91 and 79.86 ± 0.59 for the groups treated with 50 and 100 mg/kg of extract of M. vulgare and omeprazole (30 mg/kg), respectively. For indomethacin‐induced ulcers, the percentages of ulcer inhibition were 50.32 ± 5.60, 66.24 ± 4.30, 82.17 ± 04.09 and 67.52 ± 4.38, for the groups treated with 25, 50 and 100 mg/kg M. vulgare and positive control (cimetidine), respectively. In both models, the marrubiin (25 mg/kg) produced a significant reduction in all the parameters when compared with the control group (P < 0.01). There was also a significant increase in pH and mucus production in the groups treated with M. vulgare extract and marubiin. The results also demonstrated that the gastroprotection induced by the extract and marubiin is related to the activity of nitric oxide and endogenous sulfhydryls, which are important gastroprotective factors.
Conclusions The results of this study show that the extract of M. vulgare and marrubiin displays antiulcer activity and that this effect can be partly attributed to the isolated diterpene.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21827496</pmid><doi>10.1111/j.2042-7158.2011.01321.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anti-Ulcer Agents - isolation & purification Anti-Ulcer Agents - pharmacology Anti-Ulcer Agents - therapeutic use antiulcerogenic activity Disease Models, Animal diterpene Diterpenes - isolation & purification Diterpenes - pharmacology Diterpenes - therapeutic use Ethanol Gastric Acid - secretion gastroprotection Hydrogen-Ion Concentration Indomethacin marrubiin Marrubium - chemistry Marrubium vulgare Mice Mucus - metabolism Nitric Oxide - metabolism Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Leaves Stomach Ulcer - chemically induced Stomach Ulcer - drug therapy |
| title | Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L. (Lamiaceae) |
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