SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53

Nephrotoxicity is one of the important dose-limiting factors during cisplatin treatment. There is a growing body of evidence that activation of p53 has a critical role in cisplatin-induced renal apoptotic injury. The nicotinamide adenine dinucleotide-dependent protein deacetylase SIRT1 decreases apo...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2011-08, Vol.301 (2), p.F427-F435
Hauptverfasser:	Kim, Duk Hoon, Jung, Yu Jin, Lee, Jung Eun, Lee, Ae Sin, Kang, Kyung Pyo, Lee, Sik, Park, Sung Kwang, Han, Myung Kwan, Lee, Sang Yong, Ramkumar, Kunga Mohan, Sung, Mi Jeong, Kim, Won
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Acute Kidney Injury - chemically induced Acute Kidney Injury - enzymology Acute Kidney Injury - prevention & control Animals Antineoplastic Agents - adverse effects Antioxidants - pharmacology Antioxidants - therapeutic use Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism bcl-2-Associated X Protein - metabolism bcl-X Protein - metabolism Carbazoles Caspase 3 - metabolism Cisplatin - adverse effects Enzyme Activation - drug effects Hepatitis A Virus Cellular Receptor 1 Kidney diseases Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - enzymology Male Medical treatment Membrane Proteins - urine Mice Mice, Inbred C57BL Proteins Signal Transduction Sirtuin 1 - antagonists & inhibitors Sirtuin 1 - drug effects Sirtuin 1 - metabolism Stilbenes - pharmacology Stilbenes - therapeutic use Toxicity Tumor Suppressor Protein p53 - antagonists & inhibitors Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins - metabolism
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