Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial
Background/Objectives: In vitro and animal studies have reported that young broccoli sprouts improve oxidative stress status in diabetic condition. The objective of this double-blind, placebo-controlled, randomized clinical trial was to investigate the effects of broccoli sprouts powder (BSP) on som...
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| Veröffentlicht in: | European journal of clinical nutrition 2011-08, Vol.65 (8), p.972-977 |
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| container_title | European journal of clinical nutrition |
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| creator | Bahadoran, Z Mirmiran, P Hosseinpanah, F Hedayati, M Hosseinpour-Niazi, S Azizi, F |
| description | Background/Objectives:
In vitro
and animal studies have reported that young broccoli sprouts improve oxidative stress status in diabetic condition. The objective of this double-blind, placebo-controlled, randomized clinical trial was to investigate the effects of broccoli sprouts powder (BSP) on some oxidative stress parameters in type 2 diabetes patients.
Subjects/Methods:
A total of 81 patients with type 2 diabetes were randomly assigned to one of three treatment groups for 4 weeks. The groups received either 10 g/d BSP (
n
=27), 5 g/d BSP (
n
=29) or placebo (
n
=25). Serum total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and oxidized low density lipoprotein (LDL) cholesterol were measured at baseline and at 4 weeks after treatment.
Results:
In all, 63 patients in three groups were included in the analysis: 10 g/d BSP (
n
=21), 5 g/d (
n
=22) and placebo (
n
=20). After 4 weeks, consumption of BSP resulted in significant decrease in MDA (
P
=0.001 for treatment effect), oxidized low density lipoprotein cholesterol (
P
=0.03 for treatment effect), OSI (
P
=0.001 for treatment effect) and significant increase in TAC (
P
=0.001 for treatment effect). No effects were found on TOS.
Conclusion:
BSP had favorable effects on oxidative stress status in type 2 diabetes patients. |
| doi_str_mv | 10.1038/ejcn.2011.59 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_881086709</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A264271430</galeid><sourcerecordid>A264271430</sourcerecordid><originalsourceid>FETCH-LOGICAL-c587t-e386b8bdffb170ea757b85454ff5fd428489f99f42573afef117c6089b13dd463</originalsourceid><addsrcrecordid>eNp10s-P1CAUB_DGaNxx9ebZEM3qxY7QQqHe1o2_kk286Lmh8JhlQmEEatz966XZ0XHNGJKSlM8r8PqtqqcErwluxRvYKr9uMCFr1t-rVoTyrmYdxferFe4ZrVuM-Un1KKUtxmWRNw-rk4Yw1pfiVQXvYlAqOIvSLoY5JxRBzwpQ-Gm1zPYHoJQjpISsR_l6B6hB2soRMqS3SKIovQ6TvQGNdJhHB_XorNdIladV0qEcrXSPqwdGugRP9vNp9e3D-68Xn-rLLx8_X5xf1ooJnmtoRTeKURszEo5BcsZHwSijxjCjaSOo6E3fG9ow3koDhhCuOiz6kbRa0649rV7dfrfc5fsMKQ-TTQqckx7CnAYhCBYdx32Rz_-R2zBHXw5XEOaMcdwU9OJ_qOnKcZpGtOSgNtLBYL0JOUq1bDycL4wT2uKi6iNqAx6idMGDseX1Hb8-4svQMFl1tODlXwVXIF2-SsHN2Qaf7sLXt1DFkFIEM-yinWS8HggelkgNS6SGJVIDWzr1bN-EeZxA_8G_M1TA2R7IVP64KZFQNh0cbbuWdOLQgZI06zcQD908uvEvER3fYQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2642822831</pqid></control><display><type>article</type><title>Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Bahadoran, Z ; Mirmiran, P ; Hosseinpanah, F ; Hedayati, M ; Hosseinpour-Niazi, S ; Azizi, F</creator><creatorcontrib>Bahadoran, Z ; Mirmiran, P ; Hosseinpanah, F ; Hedayati, M ; Hosseinpour-Niazi, S ; Azizi, F</creatorcontrib><description>Background/Objectives:
In vitro
and animal studies have reported that young broccoli sprouts improve oxidative stress status in diabetic condition. The objective of this double-blind, placebo-controlled, randomized clinical trial was to investigate the effects of broccoli sprouts powder (BSP) on some oxidative stress parameters in type 2 diabetes patients.
Subjects/Methods:
A total of 81 patients with type 2 diabetes were randomly assigned to one of three treatment groups for 4 weeks. The groups received either 10 g/d BSP (
n
=27), 5 g/d BSP (
n
=29) or placebo (
n
=25). Serum total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and oxidized low density lipoprotein (LDL) cholesterol were measured at baseline and at 4 weeks after treatment.
Results:
In all, 63 patients in three groups were included in the analysis: 10 g/d BSP (
n
=21), 5 g/d (
n
=22) and placebo (
n
=20). After 4 weeks, consumption of BSP resulted in significant decrease in MDA (
P
=0.001 for treatment effect), oxidized low density lipoprotein cholesterol (
P
=0.03 for treatment effect), OSI (
P
=0.001 for treatment effect) and significant increase in TAC (
P
=0.001 for treatment effect). No effects were found on TOS.
Conclusion:
BSP had favorable effects on oxidative stress status in type 2 diabetes patients.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/ejcn.2011.59</identifier><identifier>PMID: 21559038</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/443/319 ; 692/308/2779/109 ; 692/699/2743/137/773 ; 692/700/459/1994 ; Adolescent ; Adult ; Antioxidants ; Antioxidants - pharmacology ; Biological and medical sciences ; Biomarkers - blood ; Brassica - chemistry ; Broccoli ; Care and treatment ; Cholesterol ; Clinical Nutrition ; Clinical trials ; Density ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes. Impaired glucose tolerance ; Dose-Response Relationship, Drug ; Double-Blind Method ; Double-blind studies ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Epidemiology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Internal Medicine ; Lipoproteins, LDL - blood ; Lipoproteins, LDL - drug effects ; Low density lipoprotein ; Male ; Malondialdehyde ; Malondialdehyde - blood ; Management ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Nutritional aspects ; original-article ; Oxidants ; Oxidative stress ; Oxidative Stress - drug effects ; Oxidizing agents ; Patients ; Phytotherapy ; Placebos ; Plant Preparations - pharmacology ; Powders - pharmacology ; Public Health ; Type 2 diabetes ; Vegetables ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Young Adult</subject><ispartof>European journal of clinical nutrition, 2011-08, Vol.65 (8), p.972-977</ispartof><rights>Macmillan Publishers Limited 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Nature Publishing Group</rights><rights>Macmillan Publishers Limited 2011.</rights><rights>Copyright Nature Publishing Group Aug 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c587t-e386b8bdffb170ea757b85454ff5fd428489f99f42573afef117c6089b13dd463</citedby><cites>FETCH-LOGICAL-c587t-e386b8bdffb170ea757b85454ff5fd428489f99f42573afef117c6089b13dd463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ejcn.2011.59$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ejcn.2011.59$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24363168$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21559038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bahadoran, Z</creatorcontrib><creatorcontrib>Mirmiran, P</creatorcontrib><creatorcontrib>Hosseinpanah, F</creatorcontrib><creatorcontrib>Hedayati, M</creatorcontrib><creatorcontrib>Hosseinpour-Niazi, S</creatorcontrib><creatorcontrib>Azizi, F</creatorcontrib><title>Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background/Objectives:
In vitro
and animal studies have reported that young broccoli sprouts improve oxidative stress status in diabetic condition. The objective of this double-blind, placebo-controlled, randomized clinical trial was to investigate the effects of broccoli sprouts powder (BSP) on some oxidative stress parameters in type 2 diabetes patients.
Subjects/Methods:
A total of 81 patients with type 2 diabetes were randomly assigned to one of three treatment groups for 4 weeks. The groups received either 10 g/d BSP (
n
=27), 5 g/d BSP (
n
=29) or placebo (
n
=25). Serum total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and oxidized low density lipoprotein (LDL) cholesterol were measured at baseline and at 4 weeks after treatment.
Results:
In all, 63 patients in three groups were included in the analysis: 10 g/d BSP (
n
=21), 5 g/d (
n
=22) and placebo (
n
=20). After 4 weeks, consumption of BSP resulted in significant decrease in MDA (
P
=0.001 for treatment effect), oxidized low density lipoprotein cholesterol (
P
=0.03 for treatment effect), OSI (
P
=0.001 for treatment effect) and significant increase in TAC (
P
=0.001 for treatment effect). No effects were found on TOS.
Conclusion:
BSP had favorable effects on oxidative stress status in type 2 diabetes patients.</description><subject>631/443/319</subject><subject>692/308/2779/109</subject><subject>692/699/2743/137/773</subject><subject>692/700/459/1994</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Brassica - chemistry</subject><subject>Broccoli</subject><subject>Care and treatment</subject><subject>Cholesterol</subject><subject>Clinical Nutrition</subject><subject>Clinical trials</subject><subject>Density</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Epidemiology</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lipoproteins, LDL - blood</subject><subject>Lipoproteins, LDL - drug effects</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>Malondialdehyde - blood</subject><subject>Management</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Nutritional aspects</subject><subject>original-article</subject><subject>Oxidants</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidizing agents</subject><subject>Patients</subject><subject>Phytotherapy</subject><subject>Placebos</subject><subject>Plant Preparations - pharmacology</subject><subject>Powders - pharmacology</subject><subject>Public Health</subject><subject>Type 2 diabetes</subject><subject>Vegetables</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Young Adult</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10s-P1CAUB_DGaNxx9ebZEM3qxY7QQqHe1o2_kk286Lmh8JhlQmEEatz966XZ0XHNGJKSlM8r8PqtqqcErwluxRvYKr9uMCFr1t-rVoTyrmYdxferFe4ZrVuM-Un1KKUtxmWRNw-rk4Yw1pfiVQXvYlAqOIvSLoY5JxRBzwpQ-Gm1zPYHoJQjpISsR_l6B6hB2soRMqS3SKIovQ6TvQGNdJhHB_XorNdIladV0qEcrXSPqwdGugRP9vNp9e3D-68Xn-rLLx8_X5xf1ooJnmtoRTeKURszEo5BcsZHwSijxjCjaSOo6E3fG9ow3koDhhCuOiz6kbRa0649rV7dfrfc5fsMKQ-TTQqckx7CnAYhCBYdx32Rz_-R2zBHXw5XEOaMcdwU9OJ_qOnKcZpGtOSgNtLBYL0JOUq1bDycL4wT2uKi6iNqAx6idMGDseX1Hb8-4svQMFl1tODlXwVXIF2-SsHN2Qaf7sLXt1DFkFIEM-yinWS8HggelkgNS6SGJVIDWzr1bN-EeZxA_8G_M1TA2R7IVP64KZFQNh0cbbuWdOLQgZI06zcQD908uvEvER3fYQ</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Bahadoran, Z</creator><creator>Mirmiran, P</creator><creator>Hosseinpanah, F</creator><creator>Hedayati, M</creator><creator>Hosseinpour-Niazi, S</creator><creator>Azizi, F</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20110801</creationdate><title>Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial</title><author>Bahadoran, Z ; Mirmiran, P ; Hosseinpanah, F ; Hedayati, M ; Hosseinpour-Niazi, S ; Azizi, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c587t-e386b8bdffb170ea757b85454ff5fd428489f99f42573afef117c6089b13dd463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>631/443/319</topic><topic>692/308/2779/109</topic><topic>692/699/2743/137/773</topic><topic>692/700/459/1994</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Brassica - chemistry</topic><topic>Broccoli</topic><topic>Care and treatment</topic><topic>Cholesterol</topic><topic>Clinical Nutrition</topic><topic>Clinical trials</topic><topic>Density</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Double-blind studies</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Epidemiology</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lipoproteins, LDL - blood</topic><topic>Lipoproteins, LDL - drug effects</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Malondialdehyde - blood</topic><topic>Management</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Nutritional aspects</topic><topic>original-article</topic><topic>Oxidants</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidizing agents</topic><topic>Patients</topic><topic>Phytotherapy</topic><topic>Placebos</topic><topic>Plant Preparations - pharmacology</topic><topic>Powders - pharmacology</topic><topic>Public Health</topic><topic>Type 2 diabetes</topic><topic>Vegetables</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bahadoran, Z</creatorcontrib><creatorcontrib>Mirmiran, P</creatorcontrib><creatorcontrib>Hosseinpanah, F</creatorcontrib><creatorcontrib>Hedayati, M</creatorcontrib><creatorcontrib>Hosseinpour-Niazi, S</creatorcontrib><creatorcontrib>Azizi, F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bahadoran, Z</au><au>Mirmiran, P</au><au>Hosseinpanah, F</au><au>Hedayati, M</au><au>Hosseinpour-Niazi, S</au><au>Azizi, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>65</volume><issue>8</issue><spage>972</spage><epage>977</epage><pages>972-977</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Background/Objectives:
In vitro
and animal studies have reported that young broccoli sprouts improve oxidative stress status in diabetic condition. The objective of this double-blind, placebo-controlled, randomized clinical trial was to investigate the effects of broccoli sprouts powder (BSP) on some oxidative stress parameters in type 2 diabetes patients.
Subjects/Methods:
A total of 81 patients with type 2 diabetes were randomly assigned to one of three treatment groups for 4 weeks. The groups received either 10 g/d BSP (
n
=27), 5 g/d BSP (
n
=29) or placebo (
n
=25). Serum total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and oxidized low density lipoprotein (LDL) cholesterol were measured at baseline and at 4 weeks after treatment.
Results:
In all, 63 patients in three groups were included in the analysis: 10 g/d BSP (
n
=21), 5 g/d (
n
=22) and placebo (
n
=20). After 4 weeks, consumption of BSP resulted in significant decrease in MDA (
P
=0.001 for treatment effect), oxidized low density lipoprotein cholesterol (
P
=0.03 for treatment effect), OSI (
P
=0.001 for treatment effect) and significant increase in TAC (
P
=0.001 for treatment effect). No effects were found on TOS.
Conclusion:
BSP had favorable effects on oxidative stress status in type 2 diabetes patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21559038</pmid><doi>10.1038/ejcn.2011.59</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-3007 |
| ispartof | European journal of clinical nutrition, 2011-08, Vol.65 (8), p.972-977 |
| issn | 0954-3007 1476-5640 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_881086709 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 631/443/319 692/308/2779/109 692/699/2743/137/773 692/700/459/1994 Adolescent Adult Antioxidants Antioxidants - pharmacology Biological and medical sciences Biomarkers - blood Brassica - chemistry Broccoli Care and treatment Cholesterol Clinical Nutrition Clinical trials Density Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - drug therapy Diabetes. Impaired glucose tolerance Dose-Response Relationship, Drug Double-Blind Method Double-blind studies Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Internal Medicine Lipoproteins, LDL - blood Lipoproteins, LDL - drug effects Low density lipoprotein Male Malondialdehyde Malondialdehyde - blood Management Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Nutritional aspects original-article Oxidants Oxidative stress Oxidative Stress - drug effects Oxidizing agents Patients Phytotherapy Placebos Plant Preparations - pharmacology Powders - pharmacology Public Health Type 2 diabetes Vegetables Vertebrates: anatomy and physiology, studies on body, several organs or systems Young Adult |
| title | Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial |
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