Local expression of interleukin‐27 ameliorates collagen‐induced arthritis

Objective To determine the mechanism of action of interleukin‐27 (IL‐27) against rheumatoid arthritis (RA). Methods Adenovirus containing IL‐27 transcript was constructed and was locally delivered into the ankles of mice with collagen‐induced arthritis (CIA). Progression of arthritis was determined...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2011-08, Vol.63 (8), p.2289-2298
Hauptverfasser:	Pickens, Sarah R., Chamberlain, Nathan D., Volin, Michael V., Mandelin, Arthur M., Agrawal, Hemant, Matsui, Masanori, Yoshimoto, Takayuki, Shahrara, Shiva
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Animals Ankle Joint - metabolism Ankle Joint - pathology Arthritis Arthritis, Experimental - metabolism Arthritis, Experimental - pathology Arthritis, Experimental - therapy Biological and medical sciences Cytokines Disease Progression Diseases of the osteoarticular system Inflammatory joint diseases Interleukin-17 - metabolism Interleukin-17 - therapeutic use Medical research Medical sciences Mice Mice, Inbred DBA Transfection
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