MiR-126-3p regulates progesterone receptors and involves development and lactation of mouse mammary gland
MicroRNAs (miRNAs) are small (18–22 nucleotide) non-coding, endogenous regulatory RNA molecules, and they regulate gene expression at the post-transcriptional level through binding to their target mRNAs by base-pairing and subsequently inducing either translational repression or mRNA destabilization...
Gespeichert in:
| Veröffentlicht in: | Molecular and cellular biochemistry 2011-09, Vol.355 (1-2), p.17-25 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 25 |
|---|---|
| container_issue | 1-2 |
| container_start_page | 17 |
| container_title | Molecular and cellular biochemistry |
| container_volume | 355 |
| creator | Cui, Wei Li, Qingzhang Feng, Li Ding, Wei |
| description | MicroRNAs (miRNAs) are small (18–22 nucleotide) non-coding, endogenous regulatory RNA molecules, and they regulate gene expression at the post-transcriptional level through binding to their target mRNAs by base-pairing and subsequently inducing either translational repression or mRNA destabilization by plants, animals, and some viruses. In this study, combining microarray techniques with qRT-PCR, we found that miR-126-3p expression showed significant difference in the mouse mammary cycle during pregnancy, particularly on transition from pregnancy to lactation. Bioinformatics were used to predict target gene of miR-126-3p, and luciferase activity assay to test it, it showed that the progesterone receptor (PGR) 3′UTR is directly targeted by miR-126-3p. In this study, mouse mammary epithelial cells as cell model in vitro were used to study the function of miR-126-3p. Using gene silencing and over-expression for miR-126-3p, the expression of PGR protein and the secretion of casein were detected by western blotting and HPLC, respectively. To determine whether miR-126-3p can affect mouse mammary epithelial cells viability, cells were analyzed by CASY-YY. In conclusion, PGR gene confirmed miR-126-3p target genes through luciferase activity and western blotting. And miR-126-3p could also inhibit proliferation of mouse mammary epithelial cells (
P
<
0.01) and expression of
β
-casein (
P
<
0.01), and down-regulate PGR protein (
P
<
0.05). Our results suggested that miR-126-3p inhibited expression of PGR protein level as well as the proliferation of mammary epithelial cells, therefore miR-126-3p could play an important role in the process of mammary gland development. |
| doi_str_mv | 10.1007/s11010-011-0834-1 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_880998859</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A358998735</galeid><sourcerecordid>A358998735</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-2fee940c3d33f3c037e5a6001e3387f478bd977f711b66ace4906e9ab07e01a73</originalsourceid><addsrcrecordid>eNp1kV-L1TAQxYMo7vXqB_BFij74lHWmaZvmcVn8ByuC6HPITaelS9vUpL3gt3dqV0VR8hCY-Z3hzBwhniJcIoB-lRABQQKihFoVEu-JA5ZaycKguS8OoABkjVpfiEcp3QLDzD4UFzmWeaWK_CD6D_0niXkl1ZxF6tbBLZSyOYaO0kIxTMRlT_MSYsrc1GT9dA7DmZmGzjSEeaRp-dEYnF_c0ocpC202hjVRNrpxdPFb1g0MPBYPWjckenL3H8WXN68_X7-TNx_fvr--upG-UHqReUtkCvCqUapVHpSm0lXsm5SqdVvo-tQYrVuNeKoq56kwUJFxJ9AE6LQ6ipf7XF7i68pb2LFPngb2QOzK1jUYU9elYfL5X-RtWOPE5jZIlcoYYOjFDnVuINtPbVii89tIe6XKmkdpJo_i8h8Uv4bG3vMV257rfwhwF_gYUorU2jn227Esgt3CtXu4lgOzW7gWWfPszu96Gqn5pfiZJgP5DiRuTR3F3wv9f-p3d4GtSQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>880353990</pqid></control><display><type>article</type><title>MiR-126-3p regulates progesterone receptors and involves development and lactation of mouse mammary gland</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Cui, Wei ; Li, Qingzhang ; Feng, Li ; Ding, Wei</creator><creatorcontrib>Cui, Wei ; Li, Qingzhang ; Feng, Li ; Ding, Wei</creatorcontrib><description>MicroRNAs (miRNAs) are small (18–22 nucleotide) non-coding, endogenous regulatory RNA molecules, and they regulate gene expression at the post-transcriptional level through binding to their target mRNAs by base-pairing and subsequently inducing either translational repression or mRNA destabilization by plants, animals, and some viruses. In this study, combining microarray techniques with qRT-PCR, we found that miR-126-3p expression showed significant difference in the mouse mammary cycle during pregnancy, particularly on transition from pregnancy to lactation. Bioinformatics were used to predict target gene of miR-126-3p, and luciferase activity assay to test it, it showed that the progesterone receptor (PGR) 3′UTR is directly targeted by miR-126-3p. In this study, mouse mammary epithelial cells as cell model in vitro were used to study the function of miR-126-3p. Using gene silencing and over-expression for miR-126-3p, the expression of PGR protein and the secretion of casein were detected by western blotting and HPLC, respectively. To determine whether miR-126-3p can affect mouse mammary epithelial cells viability, cells were analyzed by CASY-YY. In conclusion, PGR gene confirmed miR-126-3p target genes through luciferase activity and western blotting. And miR-126-3p could also inhibit proliferation of mouse mammary epithelial cells (
P
<
0.01) and expression of
β
-casein (
P
<
0.01), and down-regulate PGR protein (
P
<
0.05). Our results suggested that miR-126-3p inhibited expression of PGR protein level as well as the proliferation of mammary epithelial cells, therefore miR-126-3p could play an important role in the process of mammary gland development.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-011-0834-1</identifier><identifier>PMID: 21526342</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>3' Untranslated Regions ; Analysis ; Animals ; Biochemistry ; Bioinformatics ; Biomedical and Life Sciences ; Cardiology ; Casein ; Caseins - metabolism ; Caseins - secretion ; Cell Survival - genetics ; Cells, Cultured ; Epithelium - metabolism ; Epithelium - secretion ; Female ; Gene Expression ; Gene Expression Regulation, Developmental ; Genes, Reporter ; Genetic engineering ; Genetic transcription ; Lactation - genetics ; Life Sciences ; Liquid chromatography ; Luciferase ; Luciferases, Firefly - biosynthesis ; Luciferases, Firefly - genetics ; Mammary Glands, Animal - cytology ; Mammary Glands, Animal - growth & development ; Medical Biochemistry ; Mice ; Mice, Inbred BALB C ; MicroRNA ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Oncology ; Polymerase chain reaction ; Pregnancy ; Progesterone ; Receptors, Progesterone - genetics ; Receptors, Progesterone - metabolism ; Rodents</subject><ispartof>Molecular and cellular biochemistry, 2011-09, Vol.355 (1-2), p.17-25</ispartof><rights>Springer Science+Business Media, LLC. 2011</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-2fee940c3d33f3c037e5a6001e3387f478bd977f711b66ace4906e9ab07e01a73</citedby><cites>FETCH-LOGICAL-c437t-2fee940c3d33f3c037e5a6001e3387f478bd977f711b66ace4906e9ab07e01a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11010-011-0834-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11010-011-0834-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21526342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cui, Wei</creatorcontrib><creatorcontrib>Li, Qingzhang</creatorcontrib><creatorcontrib>Feng, Li</creatorcontrib><creatorcontrib>Ding, Wei</creatorcontrib><title>MiR-126-3p regulates progesterone receptors and involves development and lactation of mouse mammary gland</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><addtitle>Mol Cell Biochem</addtitle><description>MicroRNAs (miRNAs) are small (18–22 nucleotide) non-coding, endogenous regulatory RNA molecules, and they regulate gene expression at the post-transcriptional level through binding to their target mRNAs by base-pairing and subsequently inducing either translational repression or mRNA destabilization by plants, animals, and some viruses. In this study, combining microarray techniques with qRT-PCR, we found that miR-126-3p expression showed significant difference in the mouse mammary cycle during pregnancy, particularly on transition from pregnancy to lactation. Bioinformatics were used to predict target gene of miR-126-3p, and luciferase activity assay to test it, it showed that the progesterone receptor (PGR) 3′UTR is directly targeted by miR-126-3p. In this study, mouse mammary epithelial cells as cell model in vitro were used to study the function of miR-126-3p. Using gene silencing and over-expression for miR-126-3p, the expression of PGR protein and the secretion of casein were detected by western blotting and HPLC, respectively. To determine whether miR-126-3p can affect mouse mammary epithelial cells viability, cells were analyzed by CASY-YY. In conclusion, PGR gene confirmed miR-126-3p target genes through luciferase activity and western blotting. And miR-126-3p could also inhibit proliferation of mouse mammary epithelial cells (
P
<
0.01) and expression of
β
-casein (
P
<
0.01), and down-regulate PGR protein (
P
<
0.05). Our results suggested that miR-126-3p inhibited expression of PGR protein level as well as the proliferation of mammary epithelial cells, therefore miR-126-3p could play an important role in the process of mammary gland development.</description><subject>3' Untranslated Regions</subject><subject>Analysis</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Bioinformatics</subject><subject>Biomedical and Life Sciences</subject><subject>Cardiology</subject><subject>Casein</subject><subject>Caseins - metabolism</subject><subject>Caseins - secretion</subject><subject>Cell Survival - genetics</subject><subject>Cells, Cultured</subject><subject>Epithelium - metabolism</subject><subject>Epithelium - secretion</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes, Reporter</subject><subject>Genetic engineering</subject><subject>Genetic transcription</subject><subject>Lactation - genetics</subject><subject>Life Sciences</subject><subject>Liquid chromatography</subject><subject>Luciferase</subject><subject>Luciferases, Firefly - biosynthesis</subject><subject>Luciferases, Firefly - genetics</subject><subject>Mammary Glands, Animal - cytology</subject><subject>Mammary Glands, Animal - growth & development</subject><subject>Medical Biochemistry</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>MicroRNA</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Oncology</subject><subject>Polymerase chain reaction</subject><subject>Pregnancy</subject><subject>Progesterone</subject><subject>Receptors, Progesterone - genetics</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Rodents</subject><issn>0300-8177</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kV-L1TAQxYMo7vXqB_BFij74lHWmaZvmcVn8ByuC6HPITaelS9vUpL3gt3dqV0VR8hCY-Z3hzBwhniJcIoB-lRABQQKihFoVEu-JA5ZaycKguS8OoABkjVpfiEcp3QLDzD4UFzmWeaWK_CD6D_0niXkl1ZxF6tbBLZSyOYaO0kIxTMRlT_MSYsrc1GT9dA7DmZmGzjSEeaRp-dEYnF_c0ocpC202hjVRNrpxdPFb1g0MPBYPWjckenL3H8WXN68_X7-TNx_fvr--upG-UHqReUtkCvCqUapVHpSm0lXsm5SqdVvo-tQYrVuNeKoq56kwUJFxJ9AE6LQ6ipf7XF7i68pb2LFPngb2QOzK1jUYU9elYfL5X-RtWOPE5jZIlcoYYOjFDnVuINtPbVii89tIe6XKmkdpJo_i8h8Uv4bG3vMV257rfwhwF_gYUorU2jn227Esgt3CtXu4lgOzW7gWWfPszu96Gqn5pfiZJgP5DiRuTR3F3wv9f-p3d4GtSQ</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Cui, Wei</creator><creator>Li, Qingzhang</creator><creator>Feng, Li</creator><creator>Ding, Wei</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>MiR-126-3p regulates progesterone receptors and involves development and lactation of mouse mammary gland</title><author>Cui, Wei ; Li, Qingzhang ; Feng, Li ; Ding, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-2fee940c3d33f3c037e5a6001e3387f478bd977f711b66ace4906e9ab07e01a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>3' Untranslated Regions</topic><topic>Analysis</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Bioinformatics</topic><topic>Biomedical and Life Sciences</topic><topic>Cardiology</topic><topic>Casein</topic><topic>Caseins - metabolism</topic><topic>Caseins - secretion</topic><topic>Cell Survival - genetics</topic><topic>Cells, Cultured</topic><topic>Epithelium - metabolism</topic><topic>Epithelium - secretion</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes, Reporter</topic><topic>Genetic engineering</topic><topic>Genetic transcription</topic><topic>Lactation - genetics</topic><topic>Life Sciences</topic><topic>Liquid chromatography</topic><topic>Luciferase</topic><topic>Luciferases, Firefly - biosynthesis</topic><topic>Luciferases, Firefly - genetics</topic><topic>Mammary Glands, Animal - cytology</topic><topic>Mammary Glands, Animal - growth & development</topic><topic>Medical Biochemistry</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>MicroRNA</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Oncology</topic><topic>Polymerase chain reaction</topic><topic>Pregnancy</topic><topic>Progesterone</topic><topic>Receptors, Progesterone - genetics</topic><topic>Receptors, Progesterone - metabolism</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cui, Wei</creatorcontrib><creatorcontrib>Li, Qingzhang</creatorcontrib><creatorcontrib>Feng, Li</creatorcontrib><creatorcontrib>Ding, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cui, Wei</au><au>Li, Qingzhang</au><au>Feng, Li</au><au>Ding, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MiR-126-3p regulates progesterone receptors and involves development and lactation of mouse mammary gland</atitle><jtitle>Molecular and cellular biochemistry</jtitle><stitle>Mol Cell Biochem</stitle><addtitle>Mol Cell Biochem</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>355</volume><issue>1-2</issue><spage>17</spage><epage>25</epage><pages>17-25</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>MicroRNAs (miRNAs) are small (18–22 nucleotide) non-coding, endogenous regulatory RNA molecules, and they regulate gene expression at the post-transcriptional level through binding to their target mRNAs by base-pairing and subsequently inducing either translational repression or mRNA destabilization by plants, animals, and some viruses. In this study, combining microarray techniques with qRT-PCR, we found that miR-126-3p expression showed significant difference in the mouse mammary cycle during pregnancy, particularly on transition from pregnancy to lactation. Bioinformatics were used to predict target gene of miR-126-3p, and luciferase activity assay to test it, it showed that the progesterone receptor (PGR) 3′UTR is directly targeted by miR-126-3p. In this study, mouse mammary epithelial cells as cell model in vitro were used to study the function of miR-126-3p. Using gene silencing and over-expression for miR-126-3p, the expression of PGR protein and the secretion of casein were detected by western blotting and HPLC, respectively. To determine whether miR-126-3p can affect mouse mammary epithelial cells viability, cells were analyzed by CASY-YY. In conclusion, PGR gene confirmed miR-126-3p target genes through luciferase activity and western blotting. And miR-126-3p could also inhibit proliferation of mouse mammary epithelial cells (
P
<
0.01) and expression of
β
-casein (
P
<
0.01), and down-regulate PGR protein (
P
<
0.05). Our results suggested that miR-126-3p inhibited expression of PGR protein level as well as the proliferation of mammary epithelial cells, therefore miR-126-3p could play an important role in the process of mammary gland development.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21526342</pmid><doi>10.1007/s11010-011-0834-1</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8177 |
| ispartof | Molecular and cellular biochemistry, 2011-09, Vol.355 (1-2), p.17-25 |
| issn | 0300-8177 1573-4919 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_880998859 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 3' Untranslated Regions Analysis Animals Biochemistry Bioinformatics Biomedical and Life Sciences Cardiology Casein Caseins - metabolism Caseins - secretion Cell Survival - genetics Cells, Cultured Epithelium - metabolism Epithelium - secretion Female Gene Expression Gene Expression Regulation, Developmental Genes, Reporter Genetic engineering Genetic transcription Lactation - genetics Life Sciences Liquid chromatography Luciferase Luciferases, Firefly - biosynthesis Luciferases, Firefly - genetics Mammary Glands, Animal - cytology Mammary Glands, Animal - growth & development Medical Biochemistry Mice Mice, Inbred BALB C MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Oncology Polymerase chain reaction Pregnancy Progesterone Receptors, Progesterone - genetics Receptors, Progesterone - metabolism Rodents |
| title | MiR-126-3p regulates progesterone receptors and involves development and lactation of mouse mammary gland |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T21%3A03%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=MiR-126-3p%20regulates%20progesterone%20receptors%20and%20involves%20development%20and%20lactation%20of%20mouse%20mammary%20gland&rft.jtitle=Molecular%20and%20cellular%20biochemistry&rft.au=Cui,%20Wei&rft.date=2011-09-01&rft.volume=355&rft.issue=1-2&rft.spage=17&rft.epage=25&rft.pages=17-25&rft.issn=0300-8177&rft.eissn=1573-4919&rft_id=info:doi/10.1007/s11010-011-0834-1&rft_dat=%3Cgale_proqu%3EA358998735%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=880353990&rft_id=info:pmid/21526342&rft_galeid=A358998735&rfr_iscdi=true |