The First Nucleotide Binding Domain of the Sulfonylurea Receptor 2A Contains Regulatory Elements and Is Folded and Functions as an Independent Module

The sulfonylurea receptor 2A (SUR2A) is an ATP-binding cassette (ABC) protein that forms the regulatory subunit of ATP-sensitive potassium (KATP) channels in the heart. ATP binding and hydrolysis at the SUR2A nucleotide binding domains (NBDs) control gating of KATP channels, and mutations in the NBD...

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Veröffentlicht in:	Biochemistry (Easton) 2011-08, Vol.50 (31), p.6655-6666
Hauptverfasser:	de Araujo, Elvin D, Ikeda, Lynn K, Tzvetkova, Svetlana, Kanelis, Voula
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals ATP-Binding Cassette Transporters - biosynthesis ATP-Binding Cassette Transporters - chemistry ATP-Binding Cassette Transporters - genetics Crystallography, X-Ray DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism KATP Channels - chemistry KATP Channels - genetics KATP Channels - metabolism Molecular Sequence Data Potassium Channels, Inwardly Rectifying - biosynthesis Potassium Channels, Inwardly Rectifying - chemistry Potassium Channels, Inwardly Rectifying - genetics Protein Binding - genetics Protein Folding Protein Structure, Tertiary - genetics Rats Receptors, Drug - biosynthesis Receptors, Drug - chemistry Receptors, Drug - genetics Regulatory Elements, Transcriptional Response Elements - genetics Solubility Sulfonylurea Receptors
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