(99m)technetium-HYNIC(tricine/TPPTS)-Aca-bombesin(7-14) as a targeted imaging agent with microSPECT in a PC-3 prostate cancer xenograft model

The peptide bombesin (BN) and derivates thereof show high binding affinity for the gastrin-releasing peptide receptor (GRPR), which is highly expressed in primary and metastasized prostate cancer. We have synthesized a new BN-based radiopharmaceutical (99m)technetium-HYNIC(tricine/TPPTS)-Aca-BN(7-14...

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Veröffentlicht in:	Molecular pharmaceutics 2011-08, Vol.8 (4), p.1165-1173
Hauptverfasser:	Ananias, Hildo J K, Yu, Zilin, Dierckx, Rudi A, van der Wiele, Christophe, Helfrich, Wijnand, Wang, Fan, Yan, Yongjun, Chen, Xiaoyuan, de Jong, Igle J, Elsinga, Philip H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bombesin - chemistry Contrast Media - chemistry Humans Male Mice Mice, Nude Organotechnetium Compounds - chemistry Prostatic Neoplasms - pathology Radiochemistry Tomography, Emission-Computed, Single-Photon - methods
Online-Zugang:	Volltext
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