Determination of marker pteridines in urine by HPLC with fluorimetric detection and second-order multivariate calibration using MCR-ALS

A liquid chromatographic method has been developed, in combination with the multivariate curve resolution-alternating least squares algorithm (MCR-ALS), for the simultaneous determination of marker pteridines in urine samples. A central composite design has been applied to optimize the factors influ...

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Veröffentlicht in:	Analytical & bioanalytical chemistry (Print) 2011-02, Vol.399 (6), p.2123-2135
Hauptverfasser:	de Llanos, A. Mancha, De Zan, M. M, Culzoni, M. J, Espinosa-Mansilla, A, Cañada-Cañada, F, de la Peña, A. Muñoz, Goicoechea, H. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Algorithms Analysis Analytical Chemistry Biochemistry Biological markers Biomarkers - urine Buffers Calibration Characterization and Evaluation of Materials Chemical properties Cheminformatics Chemistry Chemistry and Materials Science Child Chromatographic methods and physical methods associated with chromatography Chromatography, High Pressure Liquid - instrumentation Chromatography, High Pressure Liquid - methods Chromatography, High Pressure Liquid - standards Computational chemistry Concentration (composition) Creatinine (CREA) Exact sciences and technology Female Flow rate Fluorescence spectroscopy Fluorometry Food Science Health aspects Heterocyclic aromatic compounds High performance liquid chromatography High-performance liquid chromatography (HPLC) Humans Laboratory Medicine Least squares Least-Squares Analysis Male Markers Mathematical analysis Mathematical optimization Metabonomic analysis Methods Monitoring/Environmental Analysis Multivariate Analysis Original Paper Other chromatographic methods Ovens Physiological aspects pteridines Pteridines - urine Pterins Spectrometric and optical methods Structure Urine
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