Microfabricated Implantable Parylene-Based Wireless Passive Intraocular Pressure Sensors
This paper presents an implantable parylene-based wireless pressure sensor for biomedical pressure sensing applications specifically designed for continuous intraocular pressure (IOP) monitoring in glaucoma patients. It has an electrical LC tank resonant circuit formed by an integrated capacitor and...
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| Veröffentlicht in: | Journal of microelectromechanical systems 2008-12, Vol.17 (6), p.1342-1351 |
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| creator | Po-Jui Chen Rodger, D.C. Saati, S. Humayun, M.S. Yu-Chong Tai |
| description | This paper presents an implantable parylene-based wireless pressure sensor for biomedical pressure sensing applications specifically designed for continuous intraocular pressure (IOP) monitoring in glaucoma patients. It has an electrical LC tank resonant circuit formed by an integrated capacitor and an inductor coil to facilitate passive wireless sensing using an external interrogating coil connected to a readout unit. Two surface-micromachined sensor designs incorporating variable capacitor and variable capacitor/inductor resonant circuits have been implemented to realize the pressure-sensitive components. The sensor is monolithically microfabricated by exploiting parylene as a biocompatible structural material in a suitable form factor for minimally invasive intraocular implantation. Pressure responses of the microsensor have been characterized to demonstrate its high pressure sensitivity ( > 7000 ppm/mmHg) in both sensor designs, which confirms the feasibility of pressure sensing with smaller than 1 mmHg of resolution for practical biomedical applications. A six-month animal study verifies the in vivo bioefficacy and biostability of the implant in the intraocular environment with no surgical or postoperative complications. Preliminary ex vivo experimental results verify the IOP sensing feasibility of such device. This sensor will ultimately be implanted at the pars plana or on the iris of the eye to fulfill continuous, convenient, direct, and faithful IOP monitoring.[2008-0111]. |
| doi_str_mv | 10.1109/JMEMS.2008.2004945 |
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It has an electrical LC tank resonant circuit formed by an integrated capacitor and an inductor coil to facilitate passive wireless sensing using an external interrogating coil connected to a readout unit. Two surface-micromachined sensor designs incorporating variable capacitor and variable capacitor/inductor resonant circuits have been implemented to realize the pressure-sensitive components. The sensor is monolithically microfabricated by exploiting parylene as a biocompatible structural material in a suitable form factor for minimally invasive intraocular implantation. Pressure responses of the microsensor have been characterized to demonstrate its high pressure sensitivity ( > 7000 ppm/mmHg) in both sensor designs, which confirms the feasibility of pressure sensing with smaller than 1 mmHg of resolution for practical biomedical applications. A six-month animal study verifies the in vivo bioefficacy and biostability of the implant in the intraocular environment with no surgical or postoperative complications. Preliminary ex vivo experimental results verify the IOP sensing feasibility of such device. This sensor will ultimately be implanted at the pars plana or on the iris of the eye to fulfill continuous, convenient, direct, and faithful IOP monitoring.[2008-0111].</description><identifier>ISSN: 1057-7157</identifier><identifier>EISSN: 1941-0158</identifier><identifier>DOI: 10.1109/JMEMS.2008.2004945</identifier><identifier>CODEN: JMIYET</identifier><language>eng</language><publisher>New York, NY: IEEE</publisher><subject>Biocompatibility ; Biomedical materials ; Biomedical monitoring ; Biosensors ; Capacitive sensors ; Capacitors ; Coiling ; Coils ; Detection ; Exact sciences and technology ; Fluid dynamics ; Fundamental areas of phenomenology (including applications) ; Glaucoma ; Implantable microdevice ; Inductors ; Instrumentation for fluid dynamics ; Instruments, apparatus, components and techniques common to several branches of physics and astronomy ; intraocular pressure (IOP) ; Mechanical instruments, equipment and techniques ; Micromechanical devices and systems ; parylene ; Patient monitoring ; Physics ; pressure sensor ; RLC circuits ; Sensor phenomena and characterization ; Sensors ; Surgical implants ; wireless sensing ; Wireless sensor networks</subject><ispartof>Journal of microelectromechanical systems, 2008-12, Vol.17 (6), p.1342-1351</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. (IEEE) 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c576t-5455cd5f265f9217fe9fd711c72003b9656bdfe8d8e3ac8217ee067d6201257f3</citedby><cites>FETCH-LOGICAL-c576t-5455cd5f265f9217fe9fd711c72003b9656bdfe8d8e3ac8217ee067d6201257f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/4660282$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>314,776,780,792,27901,27902,54733</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/4660282$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21107478$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Po-Jui Chen</creatorcontrib><creatorcontrib>Rodger, D.C.</creatorcontrib><creatorcontrib>Saati, S.</creatorcontrib><creatorcontrib>Humayun, M.S.</creatorcontrib><creatorcontrib>Yu-Chong Tai</creatorcontrib><title>Microfabricated Implantable Parylene-Based Wireless Passive Intraocular Pressure Sensors</title><title>Journal of microelectromechanical systems</title><addtitle>JMEMS</addtitle><description>This paper presents an implantable parylene-based wireless pressure sensor for biomedical pressure sensing applications specifically designed for continuous intraocular pressure (IOP) monitoring in glaucoma patients. It has an electrical LC tank resonant circuit formed by an integrated capacitor and an inductor coil to facilitate passive wireless sensing using an external interrogating coil connected to a readout unit. Two surface-micromachined sensor designs incorporating variable capacitor and variable capacitor/inductor resonant circuits have been implemented to realize the pressure-sensitive components. The sensor is monolithically microfabricated by exploiting parylene as a biocompatible structural material in a suitable form factor for minimally invasive intraocular implantation. Pressure responses of the microsensor have been characterized to demonstrate its high pressure sensitivity ( > 7000 ppm/mmHg) in both sensor designs, which confirms the feasibility of pressure sensing with smaller than 1 mmHg of resolution for practical biomedical applications. A six-month animal study verifies the in vivo bioefficacy and biostability of the implant in the intraocular environment with no surgical or postoperative complications. Preliminary ex vivo experimental results verify the IOP sensing feasibility of such device. This sensor will ultimately be implanted at the pars plana or on the iris of the eye to fulfill continuous, convenient, direct, and faithful IOP monitoring.[2008-0111].</description><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Biomedical monitoring</subject><subject>Biosensors</subject><subject>Capacitive sensors</subject><subject>Capacitors</subject><subject>Coiling</subject><subject>Coils</subject><subject>Detection</subject><subject>Exact sciences and technology</subject><subject>Fluid dynamics</subject><subject>Fundamental areas of phenomenology (including applications)</subject><subject>Glaucoma</subject><subject>Implantable microdevice</subject><subject>Inductors</subject><subject>Instrumentation for fluid dynamics</subject><subject>Instruments, apparatus, components and techniques common to several branches of physics and astronomy</subject><subject>intraocular pressure (IOP)</subject><subject>Mechanical instruments, equipment and techniques</subject><subject>Micromechanical devices and systems</subject><subject>parylene</subject><subject>Patient monitoring</subject><subject>Physics</subject><subject>pressure sensor</subject><subject>RLC circuits</subject><subject>Sensor phenomena and characterization</subject><subject>Sensors</subject><subject>Surgical implants</subject><subject>wireless sensing</subject><subject>Wireless sensor networks</subject><issn>1057-7157</issn><issn>1941-0158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><recordid>eNqFkk9v1DAQxS1EJcrCF4BLhETLJcUe_z_SqsBWXVGpILhFXmcspcomi50g8e07y6564NBebMvze2M9z2PsjeBnQnD_8Wp1ubo9A87dblFe6WfsWHglai60e05nrm1thbYv2MtS7jgXSjlzzH6tupjHFNa5i2HCtlputn0YprDusboJ-W-PA9bnoVDpZ5exx1LovpTuD1bLYcphjHMfcnWTqTJnrG5xKGMur9hRCn3B14d9wX58vvx-8bW-_vZlefHpuo7amqnWSuvY6gRGJw_CJvSptUJESz7k2htt1m1C1zqUIToiELmxrQEuQNskF-x033ebx98zlqnZdCViTyZwnEvjuTSgpZVPks5xoywndMFOHiWlUtJYJ58EgRthPRgCPzwKCg7gvJewe_zdf-jdOOeB_rDxAqS1CgRBsIdoeKVkTM02dxsaF3Vqdolo_iWi2SWiOSSCRO8PnUOJoU85DLErD0ognVVka8He7rkOER_KyhgODuQ9Nv69WQ</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Po-Jui Chen</creator><creator>Rodger, D.C.</creator><creator>Saati, S.</creator><creator>Humayun, M.S.</creator><creator>Yu-Chong Tai</creator><general>IEEE</general><general>Institute of Electrical and Electronics Engineers</general><general>The Institute of Electrical and Electronics Engineers, Inc. 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It has an electrical LC tank resonant circuit formed by an integrated capacitor and an inductor coil to facilitate passive wireless sensing using an external interrogating coil connected to a readout unit. Two surface-micromachined sensor designs incorporating variable capacitor and variable capacitor/inductor resonant circuits have been implemented to realize the pressure-sensitive components. The sensor is monolithically microfabricated by exploiting parylene as a biocompatible structural material in a suitable form factor for minimally invasive intraocular implantation. Pressure responses of the microsensor have been characterized to demonstrate its high pressure sensitivity ( > 7000 ppm/mmHg) in both sensor designs, which confirms the feasibility of pressure sensing with smaller than 1 mmHg of resolution for practical biomedical applications. A six-month animal study verifies the in vivo bioefficacy and biostability of the implant in the intraocular environment with no surgical or postoperative complications. Preliminary ex vivo experimental results verify the IOP sensing feasibility of such device. This sensor will ultimately be implanted at the pars plana or on the iris of the eye to fulfill continuous, convenient, direct, and faithful IOP monitoring.[2008-0111].</abstract><cop>New York, NY</cop><pub>IEEE</pub><doi>10.1109/JMEMS.2008.2004945</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biocompatibility Biomedical materials Biomedical monitoring Biosensors Capacitive sensors Capacitors Coiling Coils Detection Exact sciences and technology Fluid dynamics Fundamental areas of phenomenology (including applications) Glaucoma Implantable microdevice Inductors Instrumentation for fluid dynamics Instruments, apparatus, components and techniques common to several branches of physics and astronomy intraocular pressure (IOP) Mechanical instruments, equipment and techniques Micromechanical devices and systems parylene Patient monitoring Physics pressure sensor RLC circuits Sensor phenomena and characterization Sensors Surgical implants wireless sensing Wireless sensor networks |
| title | Microfabricated Implantable Parylene-Based Wireless Passive Intraocular Pressure Sensors |
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