Validation of image-derived arterial input functions at the femoral artery using 18F-fluoride positron emission tomography

INTRODUCTIONThe use of image-derived arterial input functions (IDAIF) for the dynamic quantification of bone metabolism using F-fluoride positron emission tomography F-PET is an attractive alternative to direct arterial blood sampling. PURPOSES(a) To validate a method for obtaining the IDAIF by imag...

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Veröffentlicht in:Nuclear medicine communications 2011-09, Vol.32 (9), p.808-817
Hauptverfasser: Puri, Tanuj, Blake, Glen M, Frost, Michelle L, Moore, Amelia E.B, Siddique, Musib, Cook, Gary J.R, Marsden, Paul K, Fogelman, Ignac, Curran, Kathleen M
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container_issue 9
container_start_page 808
container_title Nuclear medicine communications
container_volume 32
creator Puri, Tanuj
Blake, Glen M
Frost, Michelle L
Moore, Amelia E.B
Siddique, Musib
Cook, Gary J.R
Marsden, Paul K
Fogelman, Ignac
Curran, Kathleen M
description INTRODUCTIONThe use of image-derived arterial input functions (IDAIF) for the dynamic quantification of bone metabolism using F-fluoride positron emission tomography F-PET is an attractive alternative to direct arterial blood sampling. PURPOSES(a) To validate a method for obtaining the IDAIF by imaging the femoral artery against a method for deriving the IDAIF at the aorta that was previously validated against direct arterial sampling. (b) To compare the accuracy of bone plasma clearance measurements (Ki) at the total hip site obtained using the femoral artery IDAIF against Ki values at the same site obtained using the aorta IDAIF. METHODSTwelve healthy postmenopausal women with a mean age of 62.6 years (range, 52.3–70.6 years) had 60-min dynamic F-PET scans of the lumbar spine and proximal femur 2 weeks apart. The femoral artery IDAIF was obtained from the proximal femur scan using four different algorithms(a) fixed partial volume correction (PVC) method; (b) variable PVC method; (c) Chen method; and (d) Cook–Lodge method. The aorta IDAIF was obtained from the lumbar spine scan using a previously validated method and the respective Ki values in the hip were used to assess the performance of each of the femoral artery algorithms. RESULTSWhen the femoral artery IDAIF methods were compared with the aorta IDAIF in terms of the area under the curve AUC values calculated in 4-min time intervals over 0–60 min, the absolute root mean square errors were(a) fixed PVC, 0.52; (b) variable PVC, 0.54; (c) Chen, 0.72; and (d) Cook–Lodge, 0.49 in MBq s/ml. There were small, but statistically significant differences, in the Ki values found by all four femoral artery IDAIF methods when compared with the figures obtained using the aorta IDAIF. Bland–Altman plots of Ki values showed the best agreement for the fixed PVC method with a standard deviation of 0.0020 ml/min/ml, followed by variable PVC, Cook–Lodge and Chen method with standard deviations of 0.0022, 0.0024 and 0.0042 ml/min/ml, respectively. CONCLUSIONWe have demonstrated that it is possible to measure regional bone turnover at the hip without the need to perform direct arterial sampling to acquire the arterial input function (AIF). The differences in the Ki values obtained at the hip by using aorta IDAIF and any of the four image-based AIF methods at the femoral artery were small and clinically insignificant. The performance of fixed PVC, variable PVC and Cook–Lodge method was similar although the latter was less
doi_str_mv 10.1097/MNM.0b013e328349716f
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PURPOSES(a) To validate a method for obtaining the IDAIF by imaging the femoral artery against a method for deriving the IDAIF at the aorta that was previously validated against direct arterial sampling. (b) To compare the accuracy of bone plasma clearance measurements (Ki) at the total hip site obtained using the femoral artery IDAIF against Ki values at the same site obtained using the aorta IDAIF. METHODSTwelve healthy postmenopausal women with a mean age of 62.6 years (range, 52.3–70.6 years) had 60-min dynamic F-PET scans of the lumbar spine and proximal femur 2 weeks apart. The femoral artery IDAIF was obtained from the proximal femur scan using four different algorithms(a) fixed partial volume correction (PVC) method; (b) variable PVC method; (c) Chen method; and (d) Cook–Lodge method. The aorta IDAIF was obtained from the lumbar spine scan using a previously validated method and the respective Ki values in the hip were used to assess the performance of each of the femoral artery algorithms. RESULTSWhen the femoral artery IDAIF methods were compared with the aorta IDAIF in terms of the area under the curve AUC values calculated in 4-min time intervals over 0–60 min, the absolute root mean square errors were(a) fixed PVC, 0.52; (b) variable PVC, 0.54; (c) Chen, 0.72; and (d) Cook–Lodge, 0.49 in MBq s/ml. There were small, but statistically significant differences, in the Ki values found by all four femoral artery IDAIF methods when compared with the figures obtained using the aorta IDAIF. Bland–Altman plots of Ki values showed the best agreement for the fixed PVC method with a standard deviation of 0.0020 ml/min/ml, followed by variable PVC, Cook–Lodge and Chen method with standard deviations of 0.0022, 0.0024 and 0.0042 ml/min/ml, respectively. CONCLUSIONWe have demonstrated that it is possible to measure regional bone turnover at the hip without the need to perform direct arterial sampling to acquire the arterial input function (AIF). The differences in the Ki values obtained at the hip by using aorta IDAIF and any of the four image-based AIF methods at the femoral artery were small and clinically insignificant. The performance of fixed PVC, variable PVC and Cook–Lodge method was similar although the latter was less robust than the other two methods.</description><identifier>ISSN: 0143-3636</identifier><identifier>EISSN: 1473-5628</identifier><identifier>DOI: 10.1097/MNM.0b013e328349716f</identifier><identifier>PMID: 21799369</identifier><language>eng</language><publisher>England: Lippincott Williams &amp; Wilkins, Inc</publisher><subject>Aged ; Bone and Bones - metabolism ; Female ; Femoral Artery - diagnostic imaging ; Femoral Artery - metabolism ; Femoral Artery - physiology ; Fluorides - pharmacokinetics ; Fluorine Radioisotopes ; Humans ; Kinetics ; Male ; Metabolic Clearance Rate ; Middle Aged ; Positron-Emission Tomography ; Reproducibility of Results ; Retrospective Studies ; Veins - metabolism</subject><ispartof>Nuclear medicine communications, 2011-09, Vol.32 (9), p.808-817</ispartof><rights>2011 Lippincott Williams &amp; Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1967-40912a5bb530d5b7308e3e3ad88a316a1c82fb304a6329babde40271455707213</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21799369$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Puri, Tanuj</creatorcontrib><creatorcontrib>Blake, Glen M</creatorcontrib><creatorcontrib>Frost, Michelle L</creatorcontrib><creatorcontrib>Moore, Amelia E.B</creatorcontrib><creatorcontrib>Siddique, Musib</creatorcontrib><creatorcontrib>Cook, Gary J.R</creatorcontrib><creatorcontrib>Marsden, Paul K</creatorcontrib><creatorcontrib>Fogelman, Ignac</creatorcontrib><creatorcontrib>Curran, Kathleen M</creatorcontrib><title>Validation of image-derived arterial input functions at the femoral artery using 18F-fluoride positron emission tomography</title><title>Nuclear medicine communications</title><addtitle>Nucl Med Commun</addtitle><description>INTRODUCTIONThe use of image-derived arterial input functions (IDAIF) for the dynamic quantification of bone metabolism using F-fluoride positron emission tomography F-PET is an attractive alternative to direct arterial blood sampling. PURPOSES(a) To validate a method for obtaining the IDAIF by imaging the femoral artery against a method for deriving the IDAIF at the aorta that was previously validated against direct arterial sampling. (b) To compare the accuracy of bone plasma clearance measurements (Ki) at the total hip site obtained using the femoral artery IDAIF against Ki values at the same site obtained using the aorta IDAIF. METHODSTwelve healthy postmenopausal women with a mean age of 62.6 years (range, 52.3–70.6 years) had 60-min dynamic F-PET scans of the lumbar spine and proximal femur 2 weeks apart. The femoral artery IDAIF was obtained from the proximal femur scan using four different algorithms(a) fixed partial volume correction (PVC) method; (b) variable PVC method; (c) Chen method; and (d) Cook–Lodge method. The aorta IDAIF was obtained from the lumbar spine scan using a previously validated method and the respective Ki values in the hip were used to assess the performance of each of the femoral artery algorithms. RESULTSWhen the femoral artery IDAIF methods were compared with the aorta IDAIF in terms of the area under the curve AUC values calculated in 4-min time intervals over 0–60 min, the absolute root mean square errors were(a) fixed PVC, 0.52; (b) variable PVC, 0.54; (c) Chen, 0.72; and (d) Cook–Lodge, 0.49 in MBq s/ml. There were small, but statistically significant differences, in the Ki values found by all four femoral artery IDAIF methods when compared with the figures obtained using the aorta IDAIF. Bland–Altman plots of Ki values showed the best agreement for the fixed PVC method with a standard deviation of 0.0020 ml/min/ml, followed by variable PVC, Cook–Lodge and Chen method with standard deviations of 0.0022, 0.0024 and 0.0042 ml/min/ml, respectively. CONCLUSIONWe have demonstrated that it is possible to measure regional bone turnover at the hip without the need to perform direct arterial sampling to acquire the arterial input function (AIF). The differences in the Ki values obtained at the hip by using aorta IDAIF and any of the four image-based AIF methods at the femoral artery were small and clinically insignificant. The performance of fixed PVC, variable PVC and Cook–Lodge method was similar although the latter was less robust than the other two methods.</description><subject>Aged</subject><subject>Bone and Bones - metabolism</subject><subject>Female</subject><subject>Femoral Artery - diagnostic imaging</subject><subject>Femoral Artery - metabolism</subject><subject>Femoral Artery - physiology</subject><subject>Fluorides - pharmacokinetics</subject><subject>Fluorine Radioisotopes</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Male</subject><subject>Metabolic Clearance Rate</subject><subject>Middle Aged</subject><subject>Positron-Emission Tomography</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Veins - metabolism</subject><issn>0143-3636</issn><issn>1473-5628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtv1TAQhS0EopfCP0DIO1YuYzt-ZIkqCkgtbICt5SSTew1JHGyH6vLr8aUFJFZ-zJlzPJ8Jec7hgkNrXt18uLmADrhEKaxsWsP1-IDseGMkU1rYh2QHvJFMaqnPyJOcvwKAldo8JmeCm7aVut2Rn1_8FAZfQlxoHGmY_R7ZgCn8wIH6VOrOTzQs61bouC39SZipL7QckI44x1TLv3VHuuWw7Cm3V2yctpjCgHSNOZRUvXEOOZ9CSpzjPvn1cHxKHo1-yvjsfj0nn6_efLp8x64_vn1_-fqa9bzVhjXQcuFV1ykJg-qMBIt1Zj9Y6yXXnvdWjJ2Exmsp2s53AzYgDG-UMmAEl-fk5Z3vmuL3DXNx9S09TpNfMG7ZWVs5gVKqKps7ZZ9izglHt6ZKJB0dB3eC7ip09z_02vbiPmDrZhz-Nv2h_M_3Nk6VVP42bbeY3AH9VA6ufgtoITkTwGtIPbHTlZG_AI0YjyA</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Puri, Tanuj</creator><creator>Blake, Glen M</creator><creator>Frost, Michelle L</creator><creator>Moore, Amelia E.B</creator><creator>Siddique, Musib</creator><creator>Cook, Gary J.R</creator><creator>Marsden, Paul K</creator><creator>Fogelman, Ignac</creator><creator>Curran, Kathleen M</creator><general>Lippincott Williams &amp; Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201109</creationdate><title>Validation of image-derived arterial input functions at the femoral artery using 18F-fluoride positron emission tomography</title><author>Puri, Tanuj ; Blake, Glen M ; Frost, Michelle L ; Moore, Amelia E.B ; Siddique, Musib ; Cook, Gary J.R ; Marsden, Paul K ; Fogelman, Ignac ; Curran, Kathleen M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1967-40912a5bb530d5b7308e3e3ad88a316a1c82fb304a6329babde40271455707213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Bone and Bones - metabolism</topic><topic>Female</topic><topic>Femoral Artery - diagnostic imaging</topic><topic>Femoral Artery - metabolism</topic><topic>Femoral Artery - physiology</topic><topic>Fluorides - pharmacokinetics</topic><topic>Fluorine Radioisotopes</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Male</topic><topic>Metabolic Clearance Rate</topic><topic>Middle Aged</topic><topic>Positron-Emission Tomography</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Veins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Puri, Tanuj</creatorcontrib><creatorcontrib>Blake, Glen M</creatorcontrib><creatorcontrib>Frost, Michelle L</creatorcontrib><creatorcontrib>Moore, Amelia E.B</creatorcontrib><creatorcontrib>Siddique, Musib</creatorcontrib><creatorcontrib>Cook, Gary J.R</creatorcontrib><creatorcontrib>Marsden, Paul K</creatorcontrib><creatorcontrib>Fogelman, Ignac</creatorcontrib><creatorcontrib>Curran, Kathleen M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Puri, Tanuj</au><au>Blake, Glen M</au><au>Frost, Michelle L</au><au>Moore, Amelia E.B</au><au>Siddique, Musib</au><au>Cook, Gary J.R</au><au>Marsden, Paul K</au><au>Fogelman, Ignac</au><au>Curran, Kathleen M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validation of image-derived arterial input functions at the femoral artery using 18F-fluoride positron emission tomography</atitle><jtitle>Nuclear medicine communications</jtitle><addtitle>Nucl Med Commun</addtitle><date>2011-09</date><risdate>2011</risdate><volume>32</volume><issue>9</issue><spage>808</spage><epage>817</epage><pages>808-817</pages><issn>0143-3636</issn><eissn>1473-5628</eissn><abstract>INTRODUCTIONThe use of image-derived arterial input functions (IDAIF) for the dynamic quantification of bone metabolism using F-fluoride positron emission tomography F-PET is an attractive alternative to direct arterial blood sampling. PURPOSES(a) To validate a method for obtaining the IDAIF by imaging the femoral artery against a method for deriving the IDAIF at the aorta that was previously validated against direct arterial sampling. (b) To compare the accuracy of bone plasma clearance measurements (Ki) at the total hip site obtained using the femoral artery IDAIF against Ki values at the same site obtained using the aorta IDAIF. METHODSTwelve healthy postmenopausal women with a mean age of 62.6 years (range, 52.3–70.6 years) had 60-min dynamic F-PET scans of the lumbar spine and proximal femur 2 weeks apart. The femoral artery IDAIF was obtained from the proximal femur scan using four different algorithms(a) fixed partial volume correction (PVC) method; (b) variable PVC method; (c) Chen method; and (d) Cook–Lodge method. The aorta IDAIF was obtained from the lumbar spine scan using a previously validated method and the respective Ki values in the hip were used to assess the performance of each of the femoral artery algorithms. RESULTSWhen the femoral artery IDAIF methods were compared with the aorta IDAIF in terms of the area under the curve AUC values calculated in 4-min time intervals over 0–60 min, the absolute root mean square errors were(a) fixed PVC, 0.52; (b) variable PVC, 0.54; (c) Chen, 0.72; and (d) Cook–Lodge, 0.49 in MBq s/ml. There were small, but statistically significant differences, in the Ki values found by all four femoral artery IDAIF methods when compared with the figures obtained using the aorta IDAIF. Bland–Altman plots of Ki values showed the best agreement for the fixed PVC method with a standard deviation of 0.0020 ml/min/ml, followed by variable PVC, Cook–Lodge and Chen method with standard deviations of 0.0022, 0.0024 and 0.0042 ml/min/ml, respectively. CONCLUSIONWe have demonstrated that it is possible to measure regional bone turnover at the hip without the need to perform direct arterial sampling to acquire the arterial input function (AIF). The differences in the Ki values obtained at the hip by using aorta IDAIF and any of the four image-based AIF methods at the femoral artery were small and clinically insignificant. The performance of fixed PVC, variable PVC and Cook–Lodge method was similar although the latter was less robust than the other two methods.</abstract><cop>England</cop><pub>Lippincott Williams &amp; Wilkins, Inc</pub><pmid>21799369</pmid><doi>10.1097/MNM.0b013e328349716f</doi><tpages>10</tpages></addata></record>
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subjects Aged
Bone and Bones - metabolism
Female
Femoral Artery - diagnostic imaging
Femoral Artery - metabolism
Femoral Artery - physiology
Fluorides - pharmacokinetics
Fluorine Radioisotopes
Humans
Kinetics
Male
Metabolic Clearance Rate
Middle Aged
Positron-Emission Tomography
Reproducibility of Results
Retrospective Studies
Veins - metabolism
title Validation of image-derived arterial input functions at the femoral artery using 18F-fluoride positron emission tomography
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