Impact of Renin-Angiotensin System Blockade Therapy on Outcome in Aortic Stenosis
Objectives The purpose of this study was to investigate the impact of renin-angiotensin system blockade therapy on outcomes in aortic stenosis (AS). Background Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are perceived to be relatively contraindicated in...
Gespeichert in:
| Veröffentlicht in: | Journal of the American College of Cardiology 2011-08, Vol.58 (6), p.570-576 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 576 |
|---|---|
| container_issue | 6 |
| container_start_page | 570 |
| container_title | Journal of the American College of Cardiology |
| container_volume | 58 |
| creator | Nadir, M. Adnan, MBBS Wei, Li, MPH, PhD Elder, Douglas H.J., MBChB Libianto, Renata, MBBS Lim, Tiong K., MD Pauriah, Maheshwar, MBChB Pringle, Stuart D., MD Doney, Alex D., PhD Choy, Anna-Maria, MD Struthers, Allan D., MD Lang, Chim C., MD |
| description | Objectives The purpose of this study was to investigate the impact of renin-angiotensin system blockade therapy on outcomes in aortic stenosis (AS). Background Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are perceived to be relatively contraindicated in AS. However, inhibitors of the renin-angiotensin system may be beneficial in AS through their cardioprotective and beneficial effects on left ventricular remodeling. Methods The Health Informatics dispensed prescribing, morbidity, and mortality database for the population of Tayside, Scotland, was linked through a unique patient identifier to the Tayside echocardiography database (>110,000 scans). Patients with a diagnosis of AS from 1993 to 2008 were identified. Cox regression model (adjusted for confounding variables) and propensity score analysis were used to assess the impact of ACEIs or ARBs on all-cause mortality and cardiovascular (CV) events (CV death or hospitalizations). Results A total of 2,117 patients with AS (mean age 73 ± 12 years, 46% men) were identified and 699 (33%) were on ACEI or ARB therapy. Over a mean follow-up of 4.2 years, there were 1,087 (51%) all-cause deaths and 1,018 (48%) CV events. Those treated with ACEIs or ARBs had a significantly lower all-cause mortality with an adjusted hazard ratio of 0.76 (95% confidence interval: 0.62 to 0.92, p < 0.0001) and fewer CV events with an adjusted hazard ratio of 0.77 (95% confidence interval: 0.65 to 0.92, p < 0.0001). The outcome benefits of ACEIs/ARBs were further supported by propensity score analysis. Conclusions This large observational study suggests that ACEI/ARB therapy is associated with an improved survival and a lower risk of CV events in patients with AS. |
| doi_str_mv | 10.1016/j.jacc.2011.01.063 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_880140308</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0735109711018341</els_id><sourcerecordid>3272427461</sourcerecordid><originalsourceid>FETCH-LOGICAL-c534t-2493bbbae74a7650e94bca476882f55e0f5961457f70a13c5979cde63c86b8873</originalsourceid><addsrcrecordid>eNp9kl2L1DAUhoMo7uzoH_BCCiJ71TFpPgsijIsfCwuLznod0vRU022T2aQV5t-bMqMLeyEcyM3znpzzcBB6RfCGYCLe9ZveWLupMCEbnEvQJ2hFOFcl5bV8ilZYUl4SXMszdJ5SjzEWitTP0VlFZK0YkSv07WrcGzsVoSu-g3e-3PqfLkzgk_PF7pAmGIuPQ7B3poXi9hdEsz8UwRc382TDCEWmtiFOzha7HArJpRfoWWeGBC9P7xr9-Pzp9vJreX3z5epye11aTtlUVqymTdMYkMxIwTHUrLGGSaFU1XEOuOO1IIzLTmJDqM0b1bYFQa0SjVKSrtHFse8-hvsZ0qRHlywMg_EQ5qSVwoRhilUm3zwi-zBHn4fThBOmpCCYZao6UjaGlCJ0eh_daOJBE6wX37rXi2-9-NY4l6A59PrUem5GaP9F_grOwNsTYJI1QxeNty49cIyRimYVa_T-yEFW9ttB1Mk68BZaF8FOug3u_3N8eBS3g_Mu_3gHB0gP--pUaax3y2Ush0FyQ0UZoX8At0awrw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1514876104</pqid></control><display><type>article</type><title>Impact of Renin-Angiotensin System Blockade Therapy on Outcome in Aortic Stenosis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Nadir, M. Adnan, MBBS ; Wei, Li, MPH, PhD ; Elder, Douglas H.J., MBChB ; Libianto, Renata, MBBS ; Lim, Tiong K., MD ; Pauriah, Maheshwar, MBChB ; Pringle, Stuart D., MD ; Doney, Alex D., PhD ; Choy, Anna-Maria, MD ; Struthers, Allan D., MD ; Lang, Chim C., MD</creator><creatorcontrib>Nadir, M. Adnan, MBBS ; Wei, Li, MPH, PhD ; Elder, Douglas H.J., MBChB ; Libianto, Renata, MBBS ; Lim, Tiong K., MD ; Pauriah, Maheshwar, MBChB ; Pringle, Stuart D., MD ; Doney, Alex D., PhD ; Choy, Anna-Maria, MD ; Struthers, Allan D., MD ; Lang, Chim C., MD</creatorcontrib><description>Objectives The purpose of this study was to investigate the impact of renin-angiotensin system blockade therapy on outcomes in aortic stenosis (AS). Background Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are perceived to be relatively contraindicated in AS. However, inhibitors of the renin-angiotensin system may be beneficial in AS through their cardioprotective and beneficial effects on left ventricular remodeling. Methods The Health Informatics dispensed prescribing, morbidity, and mortality database for the population of Tayside, Scotland, was linked through a unique patient identifier to the Tayside echocardiography database (>110,000 scans). Patients with a diagnosis of AS from 1993 to 2008 were identified. Cox regression model (adjusted for confounding variables) and propensity score analysis were used to assess the impact of ACEIs or ARBs on all-cause mortality and cardiovascular (CV) events (CV death or hospitalizations). Results A total of 2,117 patients with AS (mean age 73 ± 12 years, 46% men) were identified and 699 (33%) were on ACEI or ARB therapy. Over a mean follow-up of 4.2 years, there were 1,087 (51%) all-cause deaths and 1,018 (48%) CV events. Those treated with ACEIs or ARBs had a significantly lower all-cause mortality with an adjusted hazard ratio of 0.76 (95% confidence interval: 0.62 to 0.92, p < 0.0001) and fewer CV events with an adjusted hazard ratio of 0.77 (95% confidence interval: 0.65 to 0.92, p < 0.0001). The outcome benefits of ACEIs/ARBs were further supported by propensity score analysis. Conclusions This large observational study suggests that ACEI/ARB therapy is associated with an improved survival and a lower risk of CV events in patients with AS.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2011.01.063</identifier><identifier>PMID: 21798417</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Age ; Aged ; Angiotensin Receptor Antagonists - pharmacology ; angiotensin receptor blockers ; angiotensin-converting enzyme inhibitors ; Angiotensin-Converting Enzyme Inhibitors - pharmacology ; aortic stenosis ; Aortic Valve Stenosis - therapy ; Atherosclerosis ; Biological and medical sciences ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - pathology ; Cohort Studies ; Confidence intervals ; Databases, Factual ; Diabetes ; Disease ; Drug therapy ; Echocardiography - methods ; Endocardial and cardiac valvular diseases ; Enzymes ; Female ; Follow-Up Studies ; Health informatics ; Heart ; Heart attacks ; Heart failure ; Hospitalization ; Hospitals ; Humans ; Internal Medicine ; Male ; Medical Informatics - methods ; Medical prognosis ; Medical sciences ; Middle Aged ; Mortality ; Population ; Renin-Angiotensin System ; Retrospective Studies ; Risk ; Studies ; Survival analysis ; Treatment Outcome ; Ultrasonic imaging ; Variables ; Ventricular Remodeling</subject><ispartof>Journal of the American College of Cardiology, 2011-08, Vol.58 (6), p.570-576</ispartof><rights>American College of Cardiology Foundation</rights><rights>2011 American College of Cardiology Foundation</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Aug 2, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-2493bbbae74a7650e94bca476882f55e0f5961457f70a13c5979cde63c86b8873</citedby><cites>FETCH-LOGICAL-c534t-2493bbbae74a7650e94bca476882f55e0f5961457f70a13c5979cde63c86b8873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0735109711018341$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24412349$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21798417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nadir, M. Adnan, MBBS</creatorcontrib><creatorcontrib>Wei, Li, MPH, PhD</creatorcontrib><creatorcontrib>Elder, Douglas H.J., MBChB</creatorcontrib><creatorcontrib>Libianto, Renata, MBBS</creatorcontrib><creatorcontrib>Lim, Tiong K., MD</creatorcontrib><creatorcontrib>Pauriah, Maheshwar, MBChB</creatorcontrib><creatorcontrib>Pringle, Stuart D., MD</creatorcontrib><creatorcontrib>Doney, Alex D., PhD</creatorcontrib><creatorcontrib>Choy, Anna-Maria, MD</creatorcontrib><creatorcontrib>Struthers, Allan D., MD</creatorcontrib><creatorcontrib>Lang, Chim C., MD</creatorcontrib><title>Impact of Renin-Angiotensin System Blockade Therapy on Outcome in Aortic Stenosis</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Objectives The purpose of this study was to investigate the impact of renin-angiotensin system blockade therapy on outcomes in aortic stenosis (AS). Background Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are perceived to be relatively contraindicated in AS. However, inhibitors of the renin-angiotensin system may be beneficial in AS through their cardioprotective and beneficial effects on left ventricular remodeling. Methods The Health Informatics dispensed prescribing, morbidity, and mortality database for the population of Tayside, Scotland, was linked through a unique patient identifier to the Tayside echocardiography database (>110,000 scans). Patients with a diagnosis of AS from 1993 to 2008 were identified. Cox regression model (adjusted for confounding variables) and propensity score analysis were used to assess the impact of ACEIs or ARBs on all-cause mortality and cardiovascular (CV) events (CV death or hospitalizations). Results A total of 2,117 patients with AS (mean age 73 ± 12 years, 46% men) were identified and 699 (33%) were on ACEI or ARB therapy. Over a mean follow-up of 4.2 years, there were 1,087 (51%) all-cause deaths and 1,018 (48%) CV events. Those treated with ACEIs or ARBs had a significantly lower all-cause mortality with an adjusted hazard ratio of 0.76 (95% confidence interval: 0.62 to 0.92, p < 0.0001) and fewer CV events with an adjusted hazard ratio of 0.77 (95% confidence interval: 0.65 to 0.92, p < 0.0001). The outcome benefits of ACEIs/ARBs were further supported by propensity score analysis. Conclusions This large observational study suggests that ACEI/ARB therapy is associated with an improved survival and a lower risk of CV events in patients with AS.</description><subject>Age</subject><subject>Aged</subject><subject>Angiotensin Receptor Antagonists - pharmacology</subject><subject>angiotensin receptor blockers</subject><subject>angiotensin-converting enzyme inhibitors</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>aortic stenosis</subject><subject>Aortic Valve Stenosis - therapy</subject><subject>Atherosclerosis</subject><subject>Biological and medical sciences</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - pathology</subject><subject>Cohort Studies</subject><subject>Confidence intervals</subject><subject>Databases, Factual</subject><subject>Diabetes</subject><subject>Disease</subject><subject>Drug therapy</subject><subject>Echocardiography - methods</subject><subject>Endocardial and cardiac valvular diseases</subject><subject>Enzymes</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health informatics</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical Informatics - methods</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Population</subject><subject>Renin-Angiotensin System</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Studies</subject><subject>Survival analysis</subject><subject>Treatment Outcome</subject><subject>Ultrasonic imaging</subject><subject>Variables</subject><subject>Ventricular Remodeling</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kl2L1DAUhoMo7uzoH_BCCiJ71TFpPgsijIsfCwuLznod0vRU022T2aQV5t-bMqMLeyEcyM3znpzzcBB6RfCGYCLe9ZveWLupMCEbnEvQJ2hFOFcl5bV8ilZYUl4SXMszdJ5SjzEWitTP0VlFZK0YkSv07WrcGzsVoSu-g3e-3PqfLkzgk_PF7pAmGIuPQ7B3poXi9hdEsz8UwRc382TDCEWmtiFOzha7HArJpRfoWWeGBC9P7xr9-Pzp9vJreX3z5epye11aTtlUVqymTdMYkMxIwTHUrLGGSaFU1XEOuOO1IIzLTmJDqM0b1bYFQa0SjVKSrtHFse8-hvsZ0qRHlywMg_EQ5qSVwoRhilUm3zwi-zBHn4fThBOmpCCYZao6UjaGlCJ0eh_daOJBE6wX37rXi2-9-NY4l6A59PrUem5GaP9F_grOwNsTYJI1QxeNty49cIyRimYVa_T-yEFW9ttB1Mk68BZaF8FOug3u_3N8eBS3g_Mu_3gHB0gP--pUaax3y2Ush0FyQ0UZoX8At0awrw</recordid><startdate>20110802</startdate><enddate>20110802</enddate><creator>Nadir, M. Adnan, MBBS</creator><creator>Wei, Li, MPH, PhD</creator><creator>Elder, Douglas H.J., MBChB</creator><creator>Libianto, Renata, MBBS</creator><creator>Lim, Tiong K., MD</creator><creator>Pauriah, Maheshwar, MBChB</creator><creator>Pringle, Stuart D., MD</creator><creator>Doney, Alex D., PhD</creator><creator>Choy, Anna-Maria, MD</creator><creator>Struthers, Allan D., MD</creator><creator>Lang, Chim C., MD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20110802</creationdate><title>Impact of Renin-Angiotensin System Blockade Therapy on Outcome in Aortic Stenosis</title><author>Nadir, M. Adnan, MBBS ; Wei, Li, MPH, PhD ; Elder, Douglas H.J., MBChB ; Libianto, Renata, MBBS ; Lim, Tiong K., MD ; Pauriah, Maheshwar, MBChB ; Pringle, Stuart D., MD ; Doney, Alex D., PhD ; Choy, Anna-Maria, MD ; Struthers, Allan D., MD ; Lang, Chim C., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-2493bbbae74a7650e94bca476882f55e0f5961457f70a13c5979cde63c86b8873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Age</topic><topic>Aged</topic><topic>Angiotensin Receptor Antagonists - pharmacology</topic><topic>angiotensin receptor blockers</topic><topic>angiotensin-converting enzyme inhibitors</topic><topic>Angiotensin-Converting Enzyme Inhibitors - pharmacology</topic><topic>aortic stenosis</topic><topic>Aortic Valve Stenosis - therapy</topic><topic>Atherosclerosis</topic><topic>Biological and medical sciences</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - pathology</topic><topic>Cohort Studies</topic><topic>Confidence intervals</topic><topic>Databases, Factual</topic><topic>Diabetes</topic><topic>Disease</topic><topic>Drug therapy</topic><topic>Echocardiography - methods</topic><topic>Endocardial and cardiac valvular diseases</topic><topic>Enzymes</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health informatics</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Heart failure</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical Informatics - methods</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Population</topic><topic>Renin-Angiotensin System</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Studies</topic><topic>Survival analysis</topic><topic>Treatment Outcome</topic><topic>Ultrasonic imaging</topic><topic>Variables</topic><topic>Ventricular Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nadir, M. Adnan, MBBS</creatorcontrib><creatorcontrib>Wei, Li, MPH, PhD</creatorcontrib><creatorcontrib>Elder, Douglas H.J., MBChB</creatorcontrib><creatorcontrib>Libianto, Renata, MBBS</creatorcontrib><creatorcontrib>Lim, Tiong K., MD</creatorcontrib><creatorcontrib>Pauriah, Maheshwar, MBChB</creatorcontrib><creatorcontrib>Pringle, Stuart D., MD</creatorcontrib><creatorcontrib>Doney, Alex D., PhD</creatorcontrib><creatorcontrib>Choy, Anna-Maria, MD</creatorcontrib><creatorcontrib>Struthers, Allan D., MD</creatorcontrib><creatorcontrib>Lang, Chim C., MD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nadir, M. Adnan, MBBS</au><au>Wei, Li, MPH, PhD</au><au>Elder, Douglas H.J., MBChB</au><au>Libianto, Renata, MBBS</au><au>Lim, Tiong K., MD</au><au>Pauriah, Maheshwar, MBChB</au><au>Pringle, Stuart D., MD</au><au>Doney, Alex D., PhD</au><au>Choy, Anna-Maria, MD</au><au>Struthers, Allan D., MD</au><au>Lang, Chim C., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Renin-Angiotensin System Blockade Therapy on Outcome in Aortic Stenosis</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2011-08-02</date><risdate>2011</risdate><volume>58</volume><issue>6</issue><spage>570</spage><epage>576</epage><pages>570-576</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>Objectives The purpose of this study was to investigate the impact of renin-angiotensin system blockade therapy on outcomes in aortic stenosis (AS). Background Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are perceived to be relatively contraindicated in AS. However, inhibitors of the renin-angiotensin system may be beneficial in AS through their cardioprotective and beneficial effects on left ventricular remodeling. Methods The Health Informatics dispensed prescribing, morbidity, and mortality database for the population of Tayside, Scotland, was linked through a unique patient identifier to the Tayside echocardiography database (>110,000 scans). Patients with a diagnosis of AS from 1993 to 2008 were identified. Cox regression model (adjusted for confounding variables) and propensity score analysis were used to assess the impact of ACEIs or ARBs on all-cause mortality and cardiovascular (CV) events (CV death or hospitalizations). Results A total of 2,117 patients with AS (mean age 73 ± 12 years, 46% men) were identified and 699 (33%) were on ACEI or ARB therapy. Over a mean follow-up of 4.2 years, there were 1,087 (51%) all-cause deaths and 1,018 (48%) CV events. Those treated with ACEIs or ARBs had a significantly lower all-cause mortality with an adjusted hazard ratio of 0.76 (95% confidence interval: 0.62 to 0.92, p < 0.0001) and fewer CV events with an adjusted hazard ratio of 0.77 (95% confidence interval: 0.65 to 0.92, p < 0.0001). The outcome benefits of ACEIs/ARBs were further supported by propensity score analysis. Conclusions This large observational study suggests that ACEI/ARB therapy is associated with an improved survival and a lower risk of CV events in patients with AS.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21798417</pmid><doi>10.1016/j.jacc.2011.01.063</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-1097 |
| ispartof | Journal of the American College of Cardiology, 2011-08, Vol.58 (6), p.570-576 |
| issn | 0735-1097 1558-3597 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_880140308 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Age Aged Angiotensin Receptor Antagonists - pharmacology angiotensin receptor blockers angiotensin-converting enzyme inhibitors Angiotensin-Converting Enzyme Inhibitors - pharmacology aortic stenosis Aortic Valve Stenosis - therapy Atherosclerosis Biological and medical sciences Cardiology Cardiology. Vascular system Cardiovascular Cardiovascular Diseases - diagnosis Cardiovascular Diseases - pathology Cohort Studies Confidence intervals Databases, Factual Diabetes Disease Drug therapy Echocardiography - methods Endocardial and cardiac valvular diseases Enzymes Female Follow-Up Studies Health informatics Heart Heart attacks Heart failure Hospitalization Hospitals Humans Internal Medicine Male Medical Informatics - methods Medical prognosis Medical sciences Middle Aged Mortality Population Renin-Angiotensin System Retrospective Studies Risk Studies Survival analysis Treatment Outcome Ultrasonic imaging Variables Ventricular Remodeling |
| title | Impact of Renin-Angiotensin System Blockade Therapy on Outcome in Aortic Stenosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T15%3A36%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20Renin-Angiotensin%20System%20Blockade%20Therapy%20on%20Outcome%20in%20Aortic%20Stenosis&rft.jtitle=Journal%20of%20the%20American%20College%20of%20Cardiology&rft.au=Nadir,%20M.%20Adnan,%20MBBS&rft.date=2011-08-02&rft.volume=58&rft.issue=6&rft.spage=570&rft.epage=576&rft.pages=570-576&rft.issn=0735-1097&rft.eissn=1558-3597&rft.coden=JACCDI&rft_id=info:doi/10.1016/j.jacc.2011.01.063&rft_dat=%3Cproquest_cross%3E3272427461%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1514876104&rft_id=info:pmid/21798417&rft_els_id=1_s2_0_S0735109711018341&rfr_iscdi=true |