Core signaling pathways of survival/death in autophagy-related cancer networks

Autophagy (macroautophagy), an evolutionarily conserved lysosomal degradation process, is implicated in a wide variety of pathological processes including cancer. Autophagy plays the Janus role in regulating several survival or death signaling pathways that may decide the fate of cancer cell. Accumu...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2011-09, Vol.43 (9), p.1263-1266
Hauptverfasser:	Wang, Shu-ya, Yu, Qi-jia, Zhang, Ru-dian, Liu, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Regulatory Proteins Autophagy Beclin 1 biochemistry biologists Cancer Cell Survival drugs Humans Membrane Proteins Molecular Targeted Therapy mTOR Neoplasms - drug therapy Neoplasms - pathology p53 Protein Interaction Maps Signal Transduction TOR Serine-Threonine Kinases - metabolism Tumor Suppressor Protein p53 - metabolism
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